Contrast-enhanced ultrasound (CEUS) follow-up after radiofrequency ablation or cryoablation of focal liver lesions: treated-area patterns and their changes over time

2012 ◽  
Vol 23 (5) ◽  
pp. 1392-1400 ◽  
Author(s):  
Aymeric Guibal ◽  
Caroline Bertin ◽  
Sophie Egels ◽  
Eric Savier ◽  
Philippe A. Grenier ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Treated Area ◽  
Contrast Enhanced ◽  
Changes Over Time ◽  
Over Time

The role of contrast-enhanced ultrasound in detection of liver metastases from colorectal cancer: A prospective monocentric study

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15105-e15105
Author(s):  
C. Mucciarini ◽  
S. Bellentani ◽  
G. Razzini ◽  
I. Bernardini ◽  
F. Artioli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Contrast Agent ◽  
Liver Metastases ◽  
Imaging Modalities ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Specificity And Sensitivity ◽  
Contrast Enhanced

e15105 Background: Up to 15–25% of patients with colorectal cancer (CRC) will develop metacronous liver metastases during the follow up. The management and prognosis of these patients depend heavily on the early detection of metastases. The most effective surveillance strategy has not yet being extablished. The introduction of second generation ultrasound contrast agents have improved the ability of contrast-enhanced ultrasound (CEUS) in detecting and characterizing liver lesions, showing that its accuracy is comparable to that of spiral CT and MRI with a liver contrast agent, with a cost and a time saving. We tested the sensitivity and specificity of CEUS in detecting liver metastases compared with the standard imaging modalities used in the follow up of CRC. Methods: We conducted a prospective study considering all patients with a diagnosis of CRC in high risk stage II, stage III or with a previous metastasectomy of the liver. In order to detect possible metastases, the patients were followed with a follow-up schedule including a six-monthly ultrasonography alternated to an annual CT, and a six-monthly CEUS with SonoVue contrast agent for the first 3 years. Results: From January 1st to December 2008 we executed 60 CEUS, identifying thirteen suspected liver lesions. 10/13 were confirmed metastases by CT, MRI or TC/PET. 2/13 resulted benign lesions. 1/13 resulted negative at the CT but positive with a MRI. Another additional case was missed by CEUS but detected by CT. CEUS improve specificity and sensitivity compared with baseline ultrasonography. We had an histological confirmation in all cases except one. The study is still recruiting patients. Conclusions: The clinical value of CEUS as a reliable alternative to CT or MRI in characterizing focal liver lesions has been expressed in various documents and guidelines. Our preliminary results confirm the similar diagnostic performance and confidence of CEUS compared to these imaging modalities in the follow up of CRC. Further clinical studies are still needed to strenghten the existing data. No significant financial relationships to disclose.

scholarly journals Quantitative Analysis of the Time–Intensity Curve of Contrast-Enhanced Ultrasound of the Liver: Differentiation of Benign and Malignant Liver Lesions

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1244
Author(s):  
Sonja Schwarz ◽  
Dirk-André Clevert ◽  
Michael Ingrisch ◽  
Thomas Geyer ◽  
Vincent Schwarze ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Diagnostic Accuracy ◽  
Late Phase ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Malignant Lesions ◽  
Benign Liver ◽  
Benign Liver Lesions

Background: To evaluate the diagnostic accuracy of quantitative perfusion parameters in contrast-enhanced ultrasound to differentiate malignant from benign liver lesions. Methods: In this retrospective study 134 patients with a total of 139 focal liver lesions were included who underwent contrast enhanced ultrasound (CEUS) between 2008 and 2018. All examinations were performed by a single radiologist with more than 15 years of experience using a second-generation blood pool contrast agent. The standard of reference was histopathology (n = 60), MRI or CT (n = 75) or long-term CEUS follow up (n = 4). For post processing regions of interests were drawn both inside of target lesions and the liver background. Time–intensity curves were fitted to the CEUS DICOM dataset and the rise time (RT) of contrast enhancement until peak enhancement, and a late-phase ratio (LPR) of signal intensities within the lesion and the background tissue, were calculated and compared between malignant and benign liver lesion using Student’s t-test. Quantitative parameters were evaluated with respect to their diagnostic accuracy using receiver operator characteristic curves. Both features were then combined in a logistic regression model and the cumulated accuracy was assessed. Results: RT of benign lesions (14.8 ± 13.8 s, p = 0.005), and in a subgroup analysis, particular hemangiomas (23.4 ± 16.2 s, p < 0.001) differed significantly to malignant lesions (9.3 ± 3.8 s). The LPR was significantly different between benign (1.59 ± 1.59, p < 0.001) and malignant lesions (0.38 ± 0.23). Logistic regression analysis with RT and LPR combined showed a high diagnostic accuracy of quantitative CEUS parameters with areas under the curve of 0.923 (benign vs. malignant) and 0.929 (hemangioma vs. malignant. Conclusions: Quantified CEUS parameters are helpful to differentiate malignant from benign liver lesions, in particular in case of atypical hemangiomas.

Contrast-Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta-analysis

2013 ◽  
Vol 33 (5) ◽  
pp. 739-755 ◽  
Author(s):  
Mireen Friedrich-Rust ◽  
Tom Klopffleisch ◽  
Julia Nierhoff ◽  
Eva Herrmann ◽  
Johannes Vermehren ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Real-time Contrast-Enhanced Ultrasound Imaging of Infected Focal Liver Lesions

2008 ◽  
Vol 27 (4) ◽  
pp. 657-666 ◽  
Author(s):  
Guang-Jian Liu ◽  
Ming-De Lu ◽  
Xiao-Yan Xie ◽  
Hui-Xiong Xu ◽  
Zuo-Feng Xu ◽  
...  
Keyword(s):  
Real Time ◽  
Ultrasound Imaging ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Role of contrast enhanced ultrasound in characterization of focal liver lesions

2014 ◽  
Vol 45 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Shruti Thakur ◽  
Anupam Jhobta ◽  
D.S. Dhiman ◽  
R.G. Sood ◽  
Arun Chauhan ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Usefulness of real-time contrast-enhanced ultrasound guided coaxial needle biopsy for focal liver lesions

2018 ◽  
Vol 44 (1) ◽  
pp. 310-317 ◽  
Author(s):  
Xiaojing Cao ◽  
Zhenxing Liu ◽  
Xiang Zhou ◽  
Chengyun Geng ◽  
Qing Chang ◽  
...  
Keyword(s):  
Real Time ◽  
Needle Biopsy ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Guided ◽  
Coaxial Needle ◽  
Contrast Enhanced
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