To evaluate the neuroprotective effect of green synthesized iron oxide nanoparticles using aqueous extract of whole plant
of Convolvulus pluricaulis (CPIO) in scopolamine induced amnesia model. CPIO were orally tested at the dose of 100
mg/kg, 200 mg/kg and 400 mg/kg for neuroprotective effect in scopolamine induced amnesia mice. In addition,
neurobehavioral studies were carried out using elevated plus maze, Morris water maze to evaluate learning and memory in
mice in normal and scopolamine induced amnesia mice. CPIO 400 mg/kg showed a significant improvement in learning
and memory in the normal and scopolamine induced amnesia mice in exteroceptive models. Significant differences were
observed in lipid peroxidation, catalase and acetylcholinesterase by 400 mg/kg of CPIO treated amnesic animals, when
compared with untreated and scopolamine group animals. The highest dose of CPIO exhibited significant neuroprotective
effect in normal and scopolamine induced amnesia mice. They also showed significant improvement in learning and
memory in exteroceptive and interoceptive models and so might be of value in Alzheimer’s treatment.