Miniaturised percutaneous nephrolithotomy versus flexible ureteropyeloscopy: a systematic review and meta-analysis comparing clinical efficacy and safety profile

2018 ◽  
Vol 36 (7) ◽  
pp. 1127-1138 ◽  
Author(s):  
N. F. Davis ◽  
M. R. Quinlan ◽  
C. Poyet ◽  
N. Lawrentschuk ◽  
D. M. Bolton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Efficacy ◽  
Percutaneous Nephrolithotomy ◽  
Safety Profile ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Flexible Ureteropyeloscopy

Immunotherapy efficacy and safety of programmed cell death 1 (PD-1) versus programmed death ligand-1 (PD-L1) inhibitors in pan-cancer: A systematic review and meta-analysis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e14113-e14113
Author(s):  
Jianchun Duan ◽  
Longgang Cui ◽  
Guoqiang Wang ◽  
Zhengyi Zhao ◽  
Shiqing Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Safety Profile ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Programmed Cell Death 1 ◽  
The Difference ◽  
Pan Cancer

e14113 Background: Immune checkpoint inhibitors (ICIs) that target programmed cell death 1 (PD-1) and its ligand (PD-L1) have led to a paradigm shift in cancer treatment, while whether PD-1 and PD-L1 inhibitors deliver different clinical outcomes remains obscure. Here we carried out a systematic review and meta-analysis to compare the efficacy and safety profile of PD-1 and PD-L1 inhibitors in pan-cancer patients. Methods: We systematically searched PubMed, Cochrane library, and Embase from January 2000 to December 2018 for randomized controlled trials that compared PD-1/PD-L1 inhibitors with standard treatment in patients with solid tumors. We also reviewed abstracts and presentations from all major conference proceedings. Retrospective studies and trials that compared anti-PD-1/PD-L1 with other immunotherapies were excluded. The primary outcome was the difference in overall survival (OS). Studies were stratified into comparison groups upon studies mirrored with trial design and patient characteristics. Effect size in each comparison group was pooled first, the difference in overall survival was estimated, and the overall effect sizes was pooled using a random-effects model. Results: A total of 3864 publications were retrieved through initial literature search, 17 randomized controlled trials involving 9549 patients with solid tumors were included for this meta-analysis. PD-1 inhibitors exhibited significantly improved OS over PD-L1 inhibitors either in overall population (HR 0.75, 95% CI 0.64-0.87), as monotherapy (HR 0.79, 95% CI 0.65-0.96), or combination with chemotherapy (HR 0.66, 95% CI 0.53-0.82). PD-1 inhibitors also showed improved progression free survival (PFS) over PD-L1 inhibitors in overall population (HR 0.70, 95% CI 0.53-0.94). No significant difference was observed for safety profile between PD-1 inhibitors and PD-L1 inhibitors as monotherapy. PD-1 inhibitors plus chemotherapy have less Grade 3-5 adverse events than PD-L1 inhibitors plus chemotherapy (overall RR 0.84, 95% CI 0.75-0.93). Sensitivity analysis presented a satisfactory consistency of the overall estimates across these analyses. Conclusions: PD-1 inhibitors exhibited better clinical performance for survival outcome and safety profile over PD-L1 inhibitors. Future studies and explorations of the underlying mechanisms are needed for the further optimization of treatment strategies in clinical practice.

The efficacy and safety of percutaneous nephrolithotomy under general versus regional anesthesia: a systematic review and meta-analysis

Urolithiasis ◽  
2015 ◽  
Vol 43 (5) ◽  
pp. 455-466 ◽  
Author(s):  
Chunxiao Pu ◽  
Jia Wang ◽  
Yin Tang ◽  
Haichao Yuan ◽  
Jinhong Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regional Anesthesia ◽  
Percutaneous Nephrolithotomy ◽  
Meta Analysis ◽  
Efficacy And Safety

Efficacy and safety of endovascular arteriovenous fistula creation with comparison to surgically created fistulas: a systematic review and meta-analysis protocol v2

2021 ◽  
Author(s):  
Yoshinosuke Shimamura ◽  
Hajime Yamazaki ◽  
Takamasa Miyauchi ◽  
Hiroshi Ueta ◽  
Yasutaka Kuniyoshi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arteriovenous Fistula ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Systemic Review ◽  
Efficacy And Safety ◽  
Analysis Protocol

This systemic review and meta-analysis aimed to evaluated existing evidence on the clinical efficacy and safety of endovascular arteriovenous fistula creation by directly comparing it with surgical arteriovenous fistula creation among patients with chronic kidney disease requiring hemodialysis.

Clinical efficacy and safety of robotic distal gastrectomy for gastric cancer: a systematic review and meta-analysis

2022 ◽  
Author(s):  
Shiyi Gong ◽  
Xiong Li ◽  
Hongwei Tian ◽  
Shaoming Song ◽  
Tingting Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Clinical Efficacy ◽  
Distal Gastrectomy ◽  
Meta Analysis ◽  
Efficacy And Safety
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