scholarly journals The size of retrieved lymph nodes correlates with the number of retrieved lymph nodes and is an independent prognostic factor in patients with stage II colon cancer

2015 ◽  
Vol 30 (12) ◽  
pp. 1685-1693 ◽  
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Toshiyuki Suzuki ◽  
Akira Tanaka ◽  
Gota Saito ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Independent Prognostic Factor ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

scholarly journals UCHL1 Promotes Chemoresistance to 5-Fluoruracil Based Adjuvant Chemotherapy and is a Prognostic Marker for Stage II Colon Cancer Patients

2021 ◽  
Author(s):  
Liyuan Ma ◽  
Chaowen Wu ◽  
Lu Ding ◽  
Dong Yu ◽  
Xinrong Shi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Independent Prognostic Factor ◽  
Stage Ii ◽  
Cytotoxicity Test ◽  
Down Regulation ◽  
Stage Ii Colon Cancer

Abstract Background: 5-Fluoruracil based adjuvant chemotherapy after radical resection is recommended for stage II colon cancer patients with high risk of recurrence. Up to now, novel biomarkers still needed for better stratification for improving prognosis. Methods: Here we report that UCHL1 is an independent prognostic factor for stage II colon cancer patients and promotes chemoresistance both in vitro and in vivo. Results: Our study indicated that UCHL1 is significant up regulated in 96 pairs of stage II colon cancer patients who received postoperative 5-FU based chemotherapy. Stage II colon cancer patients with high UCHL1 expression showed high recurrence rate after chemotherapy. Multivariate Cox regression analysis showed that UCHL1 is an independent prognostic factor for overall survival (P=0.008) and disease-free survival (P=0.001). 5-FU based chemoresistance is examined in colon cancer cell lines (RKO and LoVo) with down regulation of UCHL1 by cytotoxicity test. Down regulation of UCHL1 exhibited decreased cell viability, elevated cell apoptosis rate, increased G2/M-phase and elevated level of cleaved caspase 3 and PARP when treated with 5-FU. Furthermore, the results in xenograft model are consistent with results in vitro.Conclusions: UCHL1 potentially contributing to identify recurrence risk and predict the benefit for postoperative 5-FU based adjuvant chemotherapy in stage II colon cancer patients.

scholarly journals Optimal number of lymph nodes to be examined in stage II colon cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 42-50
Author(s):  
M. Yu. Fedyanin ◽  
A. A. Tryakin ◽  
A. A. Bulanov ◽  
S. S. Gordeev ◽  
D. V. Kuzmichev ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Optimal Number ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

scholarly journals The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients

2010 ◽  
Vol 21 (12) ◽  
pp. 2396-2402 ◽  
Author(s):  
A. Fariña-Sarasqueta ◽  
G. van Lijnschoten ◽  
E. Moerland ◽  
G.-J. Creemers ◽  
V.E.P.P. Lemmens ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Braf V600e Mutation ◽  
Independent Prognostic Factor ◽  
Stage Ii ◽  
Braf V600e ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

scholarly journals Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer

2009 ◽  
Vol 100 (5) ◽  
pp. 852-858 ◽  
Author(s):  
Yoshiko Inafuku ◽  
Tomohisa Furuhata ◽  
Makoto Tayama ◽  
Kenji Okita ◽  
Toshihiko Nishidate ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Matrix Metalloproteinase ◽  
Stage Ii ◽  
Matrix Metalloproteinase 2 ◽  
Stage Ii Colon Cancer

Loss of Bcl-2 expression in colon cancer: A prognostic factor for recurrence in stage II colon cancer

2009 ◽  
Vol 18 (4) ◽  
pp. 357-365 ◽  
Author(s):  
Laurent Poincloux ◽  
Xavier Durando ◽  
Jean François Seitz ◽  
Emilie Thivat ◽  
Valérie-Jeanne Bardou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

scholarly journals Hypoxia-Driven Gene Expression Is an Independent Prognostic Factor in Stage II and III Colon Cancer Patients

2014 ◽  
Vol 20 (8) ◽  
pp. 2159-2168 ◽  
Author(s):  
Jeroen Dekervel ◽  
Daphne Hompes ◽  
Hannah van Malenstein ◽  
Dusan Popovic ◽  
Xavier Sagaert ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Independent Prognostic Factor ◽  
Stage Ii

scholarly journals Targeting Lymph Node Retrieval and Assessment in Stage II Colon Cancer: A Quality Outcome Community-Based Cancer Center Study

2008 ◽  
Vol 4 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Thomas Grote ◽  
Amy H. Hughes ◽  
Cathy C. Rimmer ◽  
Dale A. Less ◽  
Amy P. Abernethy ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Median Number ◽  
Stage Ii ◽  
Tumor Board ◽  
Cancer Center ◽  
Gastrointestinal Tumor ◽  
Tumor Boards ◽  
Stage Ii Colon Cancer

Purpose Adequate lymph node evaluation is required for the proper staging of colon cancer. The current recommended number of lymph nodes that should be retrieved and assessed is 12. Methods The multidisciplinary Gastrointestinal Tumor Board at the Derrick L. Davis Forsyth Regional Cancer Center reviewed and recommended that a minimum of 12 lymph nodes be examined in all cases of colon cancer to ensure proper staging. This recommendation occurred at the end of the first quarter of 2005. To ensure this new standard was being followed, an outcomes study looking at the number of lymph nodes evaluated in stage II colon cancer was initiated. All patients with stage II colon cancer diagnosed between 2004 and 2006 were reviewed. Results There was a statistically significant improvement in the number of stage II colon cancer patients with 12 or more lymph nodes evaluated. Before the Gastrointestinal Tumor Board's recommendation, 49% (40 out of 82 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes evaluated was 11. After the Gastrointestinal Tumor Board's recommendation, 79% (70 out of 88 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes was 16. Conclusion Multidisciplinary tumor boards can impact the quality of care of patients as demonstrated in this study. Although we do not yet have survival data on these patients, based on the previous literature referenced in this article, we would expect to see an improvement in survival rates in patients with 12 or more nodes retrieved and assessed.

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