Presence of isolated tumour cells in mesenteric lymph nodes predicts poor prognosis in patients with stage II colon cancer

2003 ◽  
Vol 29 (10) ◽  
pp. 862-866 ◽  
Author(s):  
I.R.K Bukholm ◽  
J Bondi ◽  
P Wiik ◽  
J.M Nesland ◽  
S.N Andersen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Poor Prognosis ◽  
Tumour Cells ◽  
Stage Ii ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Isolated Tumour Cells ◽  
Stage Ii Colon Cancer

scholarly journals Optimal number of lymph nodes to be examined in stage II colon cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 42-50
Author(s):  
M. Yu. Fedyanin ◽  
A. A. Tryakin ◽  
A. A. Bulanov ◽  
S. S. Gordeev ◽  
D. V. Kuzmichev ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Optimal Number ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

Over expression of galectin-3 associates with short-term poor prognosis in stage II colon cancer

2017 ◽  
Vol 17 (4) ◽  
pp. 445-455 ◽  
Author(s):  
Zhiliang Huang ◽  
Zenan Ai ◽  
Nan Li ◽  
Haofeng Xi ◽  
Xucan Gao ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Poor Prognosis ◽  
Stage Ii ◽  
Short Term ◽  
Over Expression ◽  
Galectin 3 ◽  
Stage Ii Colon Cancer

scholarly journals Targeting Lymph Node Retrieval and Assessment in Stage II Colon Cancer: A Quality Outcome Community-Based Cancer Center Study

2008 ◽  
Vol 4 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Thomas Grote ◽  
Amy H. Hughes ◽  
Cathy C. Rimmer ◽  
Dale A. Less ◽  
Amy P. Abernethy ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Median Number ◽  
Stage Ii ◽  
Tumor Board ◽  
Cancer Center ◽  
Gastrointestinal Tumor ◽  
Tumor Boards ◽  
Stage Ii Colon Cancer

Purpose Adequate lymph node evaluation is required for the proper staging of colon cancer. The current recommended number of lymph nodes that should be retrieved and assessed is 12. Methods The multidisciplinary Gastrointestinal Tumor Board at the Derrick L. Davis Forsyth Regional Cancer Center reviewed and recommended that a minimum of 12 lymph nodes be examined in all cases of colon cancer to ensure proper staging. This recommendation occurred at the end of the first quarter of 2005. To ensure this new standard was being followed, an outcomes study looking at the number of lymph nodes evaluated in stage II colon cancer was initiated. All patients with stage II colon cancer diagnosed between 2004 and 2006 were reviewed. Results There was a statistically significant improvement in the number of stage II colon cancer patients with 12 or more lymph nodes evaluated. Before the Gastrointestinal Tumor Board's recommendation, 49% (40 out of 82 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes evaluated was 11. After the Gastrointestinal Tumor Board's recommendation, 79% (70 out of 88 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes was 16. Conclusion Multidisciplinary tumor boards can impact the quality of care of patients as demonstrated in this study. Although we do not yet have survival data on these patients, based on the previous literature referenced in this article, we would expect to see an improvement in survival rates in patients with 12 or more nodes retrieved and assessed.

Population based study of prognostic factors in stage II colon cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 3619-3619
Author(s):  
M. J. Morris ◽  
B. Iacopetta ◽  
C. Platell
Keyword(s):  
Colon Cancer ◽  
Prognostic Factors ◽  
Vascular Invasion ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Population Based ◽  
Stage Ii ◽  
Prognosis Group ◽  
Stage Ii Colon Cancer

3619 Background: Guidelines for the use of adjuvant chemotherapy in stage II colorectal cancer state this treatment may be considered to patients whose tumours show features of poor prognosis. The aim of the current study was to evaluate the prognostic significance of commonly reported clinical and pathological features of this disease. Methods: A population-based observational study encompassing all stage II colon cancer patients diagnosed in the state of Western Australia from 1993–2003 inclusive. A total of 1306 cases treated by surgery alone were identified and had a median follow-up of 59 months (range 0–145). Results: Multivariate analysis revealed the only independent prognostic factors for disease-specific survival were T4 stage (HR=1.75, 95%CI [1.32–2.32], P<0.0001) and vascular invasion (HR=1.63, 95%CI [1.15–2.30], P<0.0001). In the younger patient group (≤75 yrs) who are more likely to be considered for chemotherapy, the same two features showed independent prognostic significance but with higher HR values (1.96 and 2.73 respectively). T4 and/or the presence of vascular invasion identified a “poor” prognosis group comprising 26% of younger cases and having a 5-year survival rate of 71%. The remaining “good” prognosis group showed 84% survival at 5 years follow-up. Conclusion: This study highlights the importance of accurate pathological assessment of T stage and vascular invasion for the prognostic stratification of stage II colon cancer and their subsequent consideration for adjuvant chemotherapy. No significant financial relationships to disclose.

scholarly journals Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Qi Wu ◽  
Zhiyuan Zhang ◽  
Yijiao Chen ◽  
Jiang Chang ◽  
Yudong Jiang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Stage Ii ◽  
Rank Test ◽  
Chi Square ◽  
Clinical Role ◽  
Cancer Data ◽  
Kaplan Meier ◽  
Chi Square Test ◽  
Stage Ii Colon Cancer

BackgroundInadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer.MethodsThe cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables.ResultsIn total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with &lt;8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p &lt; 0.001). Multivariate analyses indicated that OS of N0 stage with &lt;8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018].ConclusionsN0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice.

Association of the number of natural killer cells and B-cell area ratios in lymph nodes with survival in patients with stage II colon cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3541-3541
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Gota Saito ◽  
Akira Tanaka ◽  
Toshiyuki Suzuki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Natural Killer Cells ◽  
Lymph Nodes ◽  
B Cell ◽  
Natural Killer ◽  
Stage Ii ◽  
Cell Area ◽  
Killer Cells ◽  
Stage Ii Colon Cancer

scholarly journals RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Sam Cross-Knorr ◽  
Shaolei Lu ◽  
Kimberly Perez ◽  
Sara Guevara ◽  
Kate Brilliant ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Stage Ii ◽  
Stage Ii Colon Cancer
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