Stage migration resulting from inadequate number of examined lymph nodes impacts prognosis in stage II colon cancer after radical surgery

2020 ◽  
Author(s):  
Di Xie ◽  
Xiangping Song ◽  
Lingling Tong
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Radical Surgery ◽  
Stage Ii ◽  
Stage Migration ◽  
Stage Ii Colon Cancer

scholarly journals Association of chemotherapy with survival in stage II colon cancer patients who received radical surgery: a retrospective cohort study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhihao Lv ◽  
Yuqi Liang ◽  
Huaxi Liu ◽  
Delong Mo
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Prediction Models ◽  
Radical Surgery ◽  
Survival Rates ◽  
Stage Ii ◽  
Survival Prediction ◽  
Stage Ii Colon Cancer ◽  
Overall Survival Rates

Abstract Background It remains controversial whether patients with Stage II colon cancer would benefit from chemotherapy after radical surgery. This study aims to assess the real effectiveness of chemotherapy in patients with stage II colon cancer undergoing radical surgery and to construct survival prediction models to predict the survival benefits of chemotherapy. Methods Data for stage II colon cancer patients with radical surgery were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (1:1) was performed according to receive or not receive chemotherapy. Competitive risk regression models were used to assess colon cancer cause-specific death (CSD) and non-colon cancer cause-specific death (NCSD). Survival prediction nomograms were constructed to predict overall survival (OS) and colon cancer cause-specific survival (CSS). The predictive abilities of the constructed models were evaluated by the concordance indexes (C-indexes) and calibration curves. Results A total of 25,110 patients were identified, 21.7% received chemotherapy, and 78.3% were without chemotherapy. A total of 10,916 patients were extracted after propensity score matching. The estimated 3-year overall survival rates of chemotherapy were 0.7% higher than non- chemotherapy. The estimated 5-year and 10-year overall survival rates of non-chemotherapy were 1.3 and 2.1% higher than chemotherapy, respectively. Survival prediction models showed good discrimination (the C-indexes between 0.582 and 0.757) and excellent calibration. Conclusions Chemotherapy improves the short-term (43 months) survival benefit of stage II colon cancer patients who received radical surgery. Survival prediction models can be used to predict OS and CSS of patients receiving chemotherapy as well as OS and CSS of patients not receiving chemotherapy and to make individualized treatment recommendations for stage II colon cancer patients who received radical surgery.

scholarly journals Optimal number of lymph nodes to be examined in stage II colon cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 42-50
Author(s):  
M. Yu. Fedyanin ◽  
A. A. Tryakin ◽  
A. A. Bulanov ◽  
S. S. Gordeev ◽  
D. V. Kuzmichev ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Optimal Number ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

scholarly journals Targeting Lymph Node Retrieval and Assessment in Stage II Colon Cancer: A Quality Outcome Community-Based Cancer Center Study

2008 ◽  
Vol 4 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Thomas Grote ◽  
Amy H. Hughes ◽  
Cathy C. Rimmer ◽  
Dale A. Less ◽  
Amy P. Abernethy ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Median Number ◽  
Stage Ii ◽  
Tumor Board ◽  
Cancer Center ◽  
Gastrointestinal Tumor ◽  
Tumor Boards ◽  
Stage Ii Colon Cancer

Purpose Adequate lymph node evaluation is required for the proper staging of colon cancer. The current recommended number of lymph nodes that should be retrieved and assessed is 12. Methods The multidisciplinary Gastrointestinal Tumor Board at the Derrick L. Davis Forsyth Regional Cancer Center reviewed and recommended that a minimum of 12 lymph nodes be examined in all cases of colon cancer to ensure proper staging. This recommendation occurred at the end of the first quarter of 2005. To ensure this new standard was being followed, an outcomes study looking at the number of lymph nodes evaluated in stage II colon cancer was initiated. All patients with stage II colon cancer diagnosed between 2004 and 2006 were reviewed. Results There was a statistically significant improvement in the number of stage II colon cancer patients with 12 or more lymph nodes evaluated. Before the Gastrointestinal Tumor Board's recommendation, 49% (40 out of 82 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes evaluated was 11. After the Gastrointestinal Tumor Board's recommendation, 79% (70 out of 88 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes was 16. Conclusion Multidisciplinary tumor boards can impact the quality of care of patients as demonstrated in this study. Although we do not yet have survival data on these patients, based on the previous literature referenced in this article, we would expect to see an improvement in survival rates in patients with 12 or more nodes retrieved and assessed.

scholarly journals Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Qi Wu ◽  
Zhiyuan Zhang ◽  
Yijiao Chen ◽  
Jiang Chang ◽  
Yudong Jiang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Stage Ii ◽  
Rank Test ◽  
Chi Square ◽  
Clinical Role ◽  
Cancer Data ◽  
Kaplan Meier ◽  
Chi Square Test ◽  
Stage Ii Colon Cancer

BackgroundInadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer.MethodsThe cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables.ResultsIn total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with <8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p < 0.001). Multivariate analyses indicated that OS of N0 stage with <8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018].ConclusionsN0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice.

Association of the number of natural killer cells and B-cell area ratios in lymph nodes with survival in patients with stage II colon cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3541-3541
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Gota Saito ◽  
Akira Tanaka ◽  
Toshiyuki Suzuki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Natural Killer Cells ◽  
Lymph Nodes ◽  
B Cell ◽  
Natural Killer ◽  
Stage Ii ◽  
Cell Area ◽  
Killer Cells ◽  
Stage Ii Colon Cancer
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