Prostate radiotherapy and the risk of secondary rectal cancer—a meta-analysis

2022 ◽  
Author(s):  
Timothy S. Nugent ◽  
Ernest Z. Low ◽  
Matthew R. Fahy ◽  
Noel E. Donlon ◽  
Paul H. McCormick ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Meta Analysis ◽  
Prostate Radiotherapy

scholarly journals Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Jae Young Moon ◽  
Min Ro Lee ◽  
Gi Won Ha
Keyword(s):  
Rectal Cancer ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Distant Recurrence ◽  
Oncologic Outcomes ◽  
Cochrane Library ◽  
Transanal Total Mesorectal Excision ◽  
Random Effects Models ◽  
The Cochrane Library

Abstract Background Transanal total mesorectal excision (TaTME) appears to have favorable surgical and pathological outcomes. However, the evidence on survival outcomes remains unclear. We performed a meta-analysis to compare long-term oncologic outcomes of TaTME with transabdominal TME for rectal cancer. Methods PubMed, EMBASE, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random-effects models. Outcome measures were overall survival (OS), disease-free survival (DFS), and local and distant recurrence. Results We included 11 nonrandomized studies that examined 2,143 patients for the meta-analysis. There were no significant differences between the two groups in OS, DFS, and local and distant recurrence with a RR of 0.65 (95% CI 0.39–1.09, I2 = 0%), 0.79 (95% CI 0.57–1.10, I2 = 0%), 1.14 (95% CI 0.44–2.91, I2 = 66%), and 0.75 (95% CI 0.40–1.41, I2 = 0%), respectively. Conclusion In terms of long-term oncologic outcomes, TaTME may be an alternative to transabdominal TME in patients with rectal cancer. Well-designed randomized trials are warranted to further verify these results.

Early-rectal Cancer Treatment: A Decision-tree Making Based on Systematic Review and Meta-analysis

2021 ◽  
Vol 99 (2) ◽  
pp. 89-107
Author(s):  
Ignacio Aguirre-Allende ◽  
Jose Maria Enriquez-Navascues ◽  
Garazi Elorza-Echaniz ◽  
Ane Etxart-Lopetegui ◽  
Nerea Borda-Arrizabalaga ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Decision Tree ◽  
Cancer Treatment ◽  
Meta Analysis ◽  
Early Rectal Cancer ◽  
Rectal Cancer Treatment

Proton beam therapy in rectal cancer: A systematic review and meta-analysis

2021 ◽  
pp. 101638
Author(s):  
Matthew Fok ◽  
Steven Toh ◽  
Jeremy Maducolil ◽  
Hayley Fowler ◽  
Rachael Clifford ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Proton Beam ◽  
Meta Analysis ◽  
Proton Beam Therapy
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