Preparation and characterization of amphiphilic nanoparticles based on chondroitin sulfate A conjugated with hydrophobic drug for enhanced doxorubicin delivery

2020 ◽  
Vol 299 (1) ◽  
pp. 129-136
Author(s):  
Xin Xie ◽  
Zhen Yuan ◽  
Qinglan Yuan ◽  
Yuyou Huang ◽  
Qunying Yu ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Hydrophobic Drug ◽  
Doxorubicin Delivery ◽  
Amphiphilic Nanoparticles ◽  
Chondroitin Sulfate A

scholarly journals Immobilization of Chondroitin Sulfate A onto Monolithic Epoxy Silica Column as a New Chiral Stationary Phase for High-Performance Liquid Chromatographic Enantioseparation

2021 ◽  
Vol 14 (2) ◽  
pp. 98
Author(s):  
Ratih Ratih ◽  
Hermann Wätzig ◽  
Azminah Azminah ◽  
Mufarreh Asmari ◽  
Benjamin Peters ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chondroitin Sulfate ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
High Performance Liquid Chromatographic ◽  
Schiff Base Formation ◽  
The Individual ◽  
Liquid Chromatographic ◽  
Base Formation ◽  
Chondroitin Sulfate A

Chondroitin sulfate A was covalently immobilized onto a monolithic silica epoxy column involving a Schiff base formation in the presence of ethylenediamine as a spacer and evaluated in terms of its selectivity in enantioseparation. The obtained column was utilized as a chiral stationary phase in enantioseparation of amlodipine and verapamil using a mobile phase consisting of 50 mM phosphate buffer pH 3.5 and UV detection. Sample dilution by organic solvents (preferably 25% v/v acetonitrile-aqueous solution) was applied to achieve baseline enantioresolution (Rs > 3.0) of the individual drug models within 7 min, an excellent linearity (R2 = 0.999) and an interday repeatability of 1.1% to 1.8% RSD. The performance of the immobilized column for quantification of racemate in commercial tablets showed a recovery of 86–98% from tablet matrices. Computational modeling by molecular docking was employed to investigate the feasible complexes between enantiomers and the chiral selector.

scholarly journals Chondroitin Sulfate: A Critical Review of Generic and Specific Problems in Its Characterization and Determination—An Exemplar of a Material with an Unknown or Variable Composition (UVCB)

2018 ◽  
Vol 101 (1) ◽  
pp. 196-202 ◽  
Author(s):  
Duncan Thorburn Burns ◽  
Michael John Walker ◽  
Christopher Mussell
Keyword(s):  
Chondroitin Sulfate ◽  
Critical Review ◽  
Analytical Methods ◽  
Cetylpyridinium Chloride ◽  
Variable Composition ◽  
Reference Samples ◽  
Selection Of ◽  
Chondroitin Sulfate A

Abstract This review discusses the criteria for the selection of appropriate reference samples of chondroitin sulfate (CS) and the properties and specific problems of analytical methods for CS, namely titration with cetylpyridinium chloride; various separations; and UV-Vis, NMR, MS, and IR spectroscopies. Suggestions are put forward with regard to acceptable protocols for manufactures’ and for official/referee analysts for the analysis of CS in products.

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