scholarly journals The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

2011 ◽  
Vol 121 (6) ◽  
pp. 737-751 ◽  
Author(s):  
Glyn Chidlow ◽  
Andreas Ebneter ◽  
John P. M. Wood ◽  
Robert J. Casson
Keyword(s):  
Optic Nerve ◽  
Axonal Transport ◽  
Optic Nerve Head ◽  
Rat Model ◽  
Axonal Regeneration ◽  
Regeneration Failure ◽  
Axonal Cytoskeleton

scholarly journals Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0167364 ◽  
Author(s):  
Shandiz Tehrani ◽  
Lauren Davis ◽  
William O. Cepurna ◽  
Tiffany E. Choe ◽  
Diana C. Lozano ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Rat Model ◽  
Molecular Response ◽  
Elevated Intraocular Pressure

Optic nerve head axonal transport in rabbits with hereditary glaucoma

1987 ◽  
Vol 44 (4) ◽  
pp. 537-551 ◽  
Author(s):  
Ann H. Bunt-Milam ◽  
Melvin B. Dennis ◽  
Richard E. Bensinger
Keyword(s):  
Optic Nerve ◽  
Axonal Transport ◽  
Optic Nerve Head

Time-Dependent Effects of Elevated Intraocular Pressure on Optic Nerve Head Axonal Transport and Cytoskeleton Proteins

2008 ◽  
Vol 49 (3) ◽  
pp. 986 ◽  
Author(s):  
Chandrakumar Balaratnasingam ◽  
William H. Morgan ◽  
Louise Bass ◽  
Stephen J. Cringle ◽  
Dao-Yi Yu
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Axonal Transport ◽  
Optic Nerve Head ◽  
Time Dependent ◽  
Elevated Intraocular Pressure

Sectoral variations in the distribution of axonal cytoskeleton proteins in the human optic nerve head

2014 ◽  
Vol 128 ◽  
pp. 141-150 ◽  
Author(s):  
Min H. Kang ◽  
Shani Law-Davis ◽  
Chandrakumar Balaratnasingam ◽  
Dao-Yi Yu
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Axonal Cytoskeleton ◽  
Human Optic Nerve

scholarly journals A method to quantify regional axonal transport blockade at the optic nerve head after short term intraocular pressure elevation in mice

2020 ◽  
Vol 196 ◽  
pp. 108035 ◽  
Author(s):  
Arina Korneva ◽  
Julie Schaub ◽  
Joan Jefferys ◽  
Elizabeth Kimball ◽  
Mary Ellen Pease ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Axonal Transport ◽  
Optic Nerve Head ◽  
Short Term ◽  
Pressure Elevation ◽  
Intraocular Pressure Elevation

PRELIMINARY STUDY ON THE BLOCKADE OF AXONAL TRANSPORT BY ACTIVATED ASTROCYTES IN OPTIC NERVE HEAD UNDER CHRONIC OCULAR HYPERTENSION

2019 ◽  
Vol 19 (07) ◽  
pp. 1940040
Author(s):  
FAN PENG ◽  
LIPING MA ◽  
LIU LIU ◽  
LIN LI ◽  
XIUQING QIAN
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Ocular Hypertension ◽  
Axonal Transport ◽  
Optic Nerve Head ◽  
Laser Scanning ◽  
Self Control ◽  
Confocal Laser ◽  
Control Group ◽  
Subconjunctival Injection

Glaucoma is considered a group of neurodegenerative diseases that damage the optic disc and result in a reduction of the field of vision. High intraocular pressure-induced deformation of optic nerve head (ONH) may compress the optic nerve and affect axonal transport. This study aims to show experimental observations: the activated astrocytes under high intraocular pressure play an important role in compression of optic nerve and block of axonal transport. Four-week duration of ocular hypertension (more than 20[Formula: see text]mm Hg) rats induced by cauterizing of three episcleral vessels and administering a fluorouracil subconjunctival injection in the right eye were enrolled and the left eyes of all the rats were used as a self-control. The axonal transport of the optic nerve was examined by a confocal laser scanning microscope after intravitreally injecting rhodamine-[Formula: see text]-isothiocyanate. The morphology of the optic nerve head was examined by hematoxylin–eosin (HE) staining, immunofluorescence staining and transmission electron microscopy (TEM). The results showed transport of rhodamine-[Formula: see text]-isothiocyanate was blocked in the experimental group, and fluorescent dye accumulated around the ONH. The nucleus counts of the coronal section kidney-shaped area showed that the number of cell nucleus in experimental eye was more than that of the control according to the results of HE staining. The increased collagen fibers in ONH were observed. The density of the glial fibrillary acidic protein in experimental eyes was a little bit higher than that in the control group by quantify analysis of the expression. The obvious changes of microstructure of the ONH also were found according to the images of TEM. It can be concluded that the activated astrocytes might squeeze the optic nerve, likely leading to optic nerve distortion and axonal flow blockage.

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