N -[4-(3-Ethoxy-2-hydropropoxy)phenyl] acrylamide selectively induces apoptosis of cerebellar granule cells in vivo and in vitro in rats

2000 ◽  
Vol 99 (4) ◽  
pp. 337-344 ◽  
Author(s):  
G. Tanaka ◽  
R. Okeda
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

scholarly journals Bone Morphogenetic Protein-6 Promotes Cerebellar Granule Neurons Survival by Activation of the MEK/ERK/CREB Pathway

2009 ◽  
Vol 20 (24) ◽  
pp. 5051-5063 ◽  
Author(s):  
Bruna Barneda-Zahonero ◽  
Alfredo Miñano-Molina ◽  
Nahuai Badiola ◽  
Rut Fadó ◽  
Xavier Xifró ◽  
...  
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Neuroprotective Effect ◽  
High Potassium ◽  
Cerebellar Granule ◽  
Low Potassium ◽  
Creb Pathway

Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival of these neurons. Lack of depolarization causes CGC death by apoptosis in vivo, a phenomenon that is mimicked in vitro by deprivation of high potassium in cultured CGCs. We have found that BMP-6, but not BMP-7, is able to block low potassium–mediated apoptosis in CGCs. The neuroprotective effect of BMP-6 is not accompanied by an increase of Smad translocation to the nucleus, suggesting that the canonical pathway is not involved. By contrast, activation of the MEK/ERK/CREB pathway by BMP-6 is necessary for its neuroprotective effect, which involves inhibition of caspase activity and an increase in Bcl-2 protein levels. Other pathways involved in the regulation of CGC survival, such as the c-Jun terminal kinase and the phosphatidylinositol 3-kinase (PI3K)-Akt/PKB, were not affected by BMP-6. Moreover, failure of BMP-7 to activate the MEK/ERK/CREB pathway could explain its inability to protect CGCs from low potassium–mediated apoptosis. Thus, this study demonstrates that BMP-6 acting through the noncanonical MEK/ERK/CREB pathway plays a crucial role on CGC survival.

The absence of pleiotrophin modulates gene expression in the hippocampus in vivo and in cerebellar granule cells in vitro

2016 ◽  
Vol 75 ◽  
pp. 113-121 ◽  
Author(s):  
Celia González-Castillo ◽  
Daniel Ortuño-Sahagún ◽  
Carolina Guzmán-Brambila ◽  
Ana Laura Márquez-Aguirre ◽  
Rita Raisman-Vozari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

Tetrabromobisphenol A-induced depolarization of rat cerebellar granule cells: ex vivo and in vitro studies

Chemosphere ◽  
2019 ◽  
Vol 223 ◽  
pp. 64-73 ◽  
Author(s):  
Dominik Diamandakis ◽  
Elzbieta Zieminska ◽  
Marcin Siwiec ◽  
Krzysztof Tokarski ◽  
Elzbieta Salinska ◽  
...  
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Ex Vivo ◽  
In Vitro Studies ◽  
Tetrabromobisphenol A ◽  
Cerebellar Granule

K252a, a potent inhibitor of protein kinases, inhibits the migration of cerebellar granule cells in vitro

1995 ◽  
Vol 90 (1-2) ◽  
pp. 122-128 ◽  
Author(s):  
Satoshi Kobayashi ◽  
Kaoru Isa ◽  
Kensuke Hayashi ◽  
Hiroshi K. Inoue ◽  
Keiichi Uyemura ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Potent Inhibitor ◽  
Cerebellar Granule
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