Serum amyloid A and C-reactive protein levels and erythrocyte sedimentation rate are important indicators in hidradenitis suppurativa

2019 ◽  
Vol 312 (4) ◽  
pp. 255-262 ◽  
Author(s):  
Neslihan Akdogan ◽  
Sibel Dogan ◽  
Pinar Incel-Uysal ◽  
Erdem Karabulut ◽  
Canan Topcuoglu ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Hidradenitis Suppurativa ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Amyloid A ◽  
Erythrocyte Sedimentation

scholarly journals The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
D. Jiménez-Gallo ◽  
R. de la Varga-Martínez ◽  
L. Ossorio-García ◽  
C. Albarrán-Planelles ◽  
C. Rodríguez ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Proinflammatory Cytokines ◽  
Sedimentation Rate ◽  
Hidradenitis Suppurativa ◽  
Staging System ◽  
Inflammatory Activity ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Objectives. To assess inflammatory serum markers including serum proinflammatory cytokines, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) according to the clinical inflammatory activity of patients with hidradenitis suppurativa (HS). Patients and Methods. Seventy-four patients with HS were studied based on the Hidradenitis Suppurativa-Physician Global Assessment (HS-PGA) score and Hurley staging system. Proinflammatory cytokines were measured using a multiplex cytokine assay. Twenty-two healthy volunteers were recruited. Results. Serum interleukin- (IL-) 6, IL-23, soluble tumour necrosis factor alpha (TNF-α) receptor I (sTNF-RI), CRP, and ESR were different in the patients with HS compared with those in the healthy controls (P<0.05). The levels of IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17A, sTNF-RII, CRP, and ESR were significantly elevated according to inflammatory activity based on HS-PGA scores (r>0.25, P<0.05). The levels of IL-6 (r=0.53, P<0.001), CRP (r=0.54, P<0.001), and ESR (r=0.60, P<0.001) were especially well correlated with clinical inflammatory activity based on HS-PGA scores. The levels of IL-6, IL-8, sTNF-RI, sTNF-RII, CRP, and ESR were significantly elevated according to Hurley staging system. Conclusions. Serum proinflammatory cytokines, CRP, and ESR are increased in relation to the clinical inflammatory activity of patients with HS compared with healthy controls. Serum IL-6, CRP, and ESR are effective biomarkers for evaluating the severity of HS.

Serum amyloid A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients

2013 ◽  
Vol 27 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Anne Julie Overgaard ◽  
James N. McGuire ◽  
Peter Hovind ◽  
Hans-Henrik Parving ◽  
Peter Rossing ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Amyloid A ◽  
Type 1 Diabetic Patients

Do Erythrocyte Sedimentation Rate and C-Reactive Protein Levels Have Diagnostic Usefulness in Patients with Renal Failure?

Nephron ◽  
2000 ◽  
Vol 86 (2) ◽  
pp. 224-224 ◽  
Author(s):  
Nurol Arık ◽  
Abdülkerim Bedir ◽  
Murat Günaydın ◽  
Bahattin Adam ◽  
Inad Halefi
Keyword(s):  
Renal Failure ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Diagnostic Usefulness

scholarly journals Serum amyloid A protein and C-reactive protein levels in pulmonary tuberculosis: relationship to amyloidosis.

Thorax ◽  
1984 ◽  
Vol 39 (3) ◽  
pp. 196-200 ◽  
Author(s):  
F C de Beer ◽  
A E Nel ◽  
R P Gie ◽  
P R Donald ◽  
A F Strachan
Keyword(s):  
Pulmonary Tuberculosis ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Amyloid A ◽  
Serum Amyloid A Protein

scholarly journals SAT0513 ASSOCIATION OF SERUM OMENTIN LEVELS WITH COLCHICINE RESISTANCE IN FAMILIAL MEDITERRANEAN FEVER

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1212.1-1213
Author(s):  
S. Can Sandikci ◽  
A. Omma ◽  
C. Yucel ◽  
T. Omma
Keyword(s):  
Familial Mediterranean Fever ◽  
Sedimentation Rate ◽  
Serum Amyloid A ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Erythrocyte Sedimentation ◽  
Colchicine Resistance ◽  
Mediterranean Fever

Background:Omentin is an anti-inflammatory adipokine, which plays important roles in the adjustments of glucose metabolism, cardiovascular homeostasis, atherosclerosis (1).Objectives:To investigate the omentin levels in Familial Mediterranean fever (FMF) patients and to assess the association with markers of subclinical inflammation in FMF patients such as serum amyloid A (SAA), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).Methods:This cross-sectional study included 54 consecutive adult FMF patients (27 male, 27 female) and 28 healthy individuals (16 male, 12 female). The demographic and clinical features and MEFV gene mutations were recorded. The FMF patients were separated into 3 groups: 1) attack-free group, 2) active attack group and 3) colchicine-resistant group. Serum omentin levels were compared between the FMF patients and the healthy control group.Results:Serum omentin and SAA levels were higher in the study group than in the control group (108.05(19.97-343.22) vs. 199.5(42.98-339.41) p<0.05, 3.69(1.18-22.75) vs. 1.31(0.95-3.16) p<0.001) (Table 1). When the FMF patients were examined as separate groups, serum omentin values were lower in the colchicine resistant group than in the groups without resistance (Table 2). The correlation analysis showed a negative correlation between omentin and SAA levels (r = -0.240, p = 0.030).Table 1.Laboratory results of the FMF and the control groupVariablesFMF patients(n=54)Control(n=28)P valueOmentin, pg/mL108.05(19.97-343.22)199.5(42.98-339.41)0.03SAA, ng/mL3.7 (1.18-22.75)1.31(0.95-3.16)<0.001ESR, mm/h15(2-68)12(7-17)<0.001CRP, mg/L12(1-194)2.5(1-8)<0.001Variables were given as median (IQR).Calculated using Mann-Whitney U test for non-normal distribution.FMF=Familial Mediterranean fever, SAA=serum amyloid A, ESR=erythrocyte sedimentation rate, CRP=C-reactive protein, IQR=interquartile range.Table 2.Laboratory results of FMF patients with and without colchicine resistanceVariablesWith resistance(n=16)Without resistance(n=38)P valueOmentin, pg/mL76.64(19.77-224.33)186.47(28.41-343.21)0.006SAA, ng/mL3.69(1.18-22.75)3.77(1.18-21.49)0.784ESR, mm/h25.5(2-68)15(2-60)0.835CRP, mg/L11(1-67)19(1-194)0.111Variables were given as median (IQR).Calculated using Mann-Whitney U test for non-normal distribution.FMF=Familial Mediterranean fever, SAA=serum amyloid A, ESR=erythrocyte sedimentation rate, CRP=C-reactive protein, IQR=interquartile range.FOMConclusion:FMF patients with colchicine resistance are associated with decreased omentin concentrations, probably mediated by inflammation-driven mechanisms.References:[1]Yue J, Chen J, Wu Q, Liu X, Li M, Li Z, Gao Y. Serum levels of omentin-1 association with early diagnosis, lesion volume and severity of acute ischemic stroke. Cytokine. 2018;111:518–522.Disclosure of Interests:None declared

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