Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

1999 ◽  
Vol 291 (5) ◽  
pp. 253-259 ◽  
Author(s):  
K. Krüger ◽  
Ulrike Blume-Peytavi ◽  
Constantin E. Orfanos
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell ◽  
Outer Root Sheath ◽  
Root Sheath ◽  
Bulge Region

scholarly journals A Case of Basal Cell Carcinoma with Outer Hair Follicle Sheath Differentiation

2015 ◽  
Vol 7 (3) ◽  
pp. 352-357
Author(s):  
Masazumi Onishi ◽  
Kazuhiro Takahashi ◽  
Fumihiko Maeda ◽  
Toshihide Akasaka
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell ◽  
Outer Root Sheath ◽  
Root Sheath ◽  
Old Japanese ◽  
Peripheral Palisading ◽  
Follicle Differentiation ◽  
Proliferating Trichilemmal Tumor

A 70-year-old Japanese man presented at our hospital with an asymptomatic, blackish, irregularly shaped plaque with a gray nodule in the periphery on his left lower leg. The lesion had been present for 10 years and had recently enlarged, associated with bleeding. Histopathologically, the tumor consisted of three distinct parts: The first part showed massive aggregation of basophilic basaloid cells with peripheral palisading and abundant melanin granules, and was diagnosed as solid-type basal cell carcinoma. The second part showed aggregation of clear cells with squamous eddies, and was diagnosed as proliferating trichilemmal tumor. The third part showed reticular aggregation of basaloid cells with infundibular cysts in the papillary dermis, and was diagnosed as infundibulocystic basal cell carcinoma. We diagnosed this tumor as basal cell carcinoma with various forms of hair follicle differentiation, including differentiation into the outer root sheath.

BOWENOID BASAL CELL CARCINOMA OF THE THUMB: A CASE REPORT AND REVIEW OF THE LITERATURE

Hand Surgery ◽  
2002 ◽  
Vol 07 (02) ◽  
pp. 295-298 ◽  
Author(s):  
M. Galeano ◽  
M. Colonna ◽  
M. Lentini ◽  
F. Stagno D'Alcontres
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Basal Layer ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Skin Malignancy ◽  
Root Sheath ◽  
Common Skin

Basal cell carcinoma (BCC) is the most common skin malignancy arising from cells of the basal layer of the epithelium or from the external root sheath of the hair follicle. BCC of the digit is a rare entity. The article presents one such case of bowenoid BCC of the thumb which required amputation at the MP joint.

scholarly journals Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma

2010 ◽  
Vol 3 (10) ◽  
pp. 1217-1221 ◽  
Author(s):  
Pamela Jo Harris ◽  
Naoko Takebe ◽  
S. Percy Ivy
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell

scholarly journals Human basal cell carcinoma: the induction of anagen hair follicle differentiation

2020 ◽  
Vol 45 (3) ◽  
pp. 309-317
Author(s):  
H. J. Morgan ◽  
A. Benketah ◽  
C. Olivero ◽  
E. Rees ◽  
S. Ziaj ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell ◽  
Anagen Hair ◽  
Follicle Differentiation ◽  
Human Basal Cell Carcinoma

scholarly journals Trichoepithelioma of thigh. Third reported case

2015 ◽  
Vol 1 (3) ◽  
pp. 187
Author(s):  
Sandesh Deolekar ◽  
Nisha Mandhane ◽  
Sharique Ansari ◽  
Tanveer Shaikh ◽  
Sangram Karandikar
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Malignant Transformation ◽  
Basal Cell ◽  
Benign Tumor ◽  
Wide Excision ◽  
Basal Cells ◽  
Close Resemblance ◽  
Adnexal Tumors

<p class="abstract"><span lang="EN-US">Trichoepithelioma a small benign tumor derived from basal cells in the hair follicle. A trichoepithelioma can undergo malignant transformation into the basal cell carcinoma. The recognition of trichoepithelioma is important because of its close resemblance to basal cell carcinoma and other skin adnexal tumors, both clinically and histopathologically. Here we present case of 40 year old male presenting with painless swelling in right thigh. Wide excision of swelling was done and sent for histopathology which showed the swelling to be trichoepithelioma.</span></p>

Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma

2019 ◽  
Vol 45 (4) ◽  
pp. 417-425
Author(s):  
H. J. Morgan ◽  
A. Benketah ◽  
C. Olivero ◽  
E. Rees ◽  
S. Ziaj ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell ◽  
Keratin Expression ◽  
Follicle Differentiation ◽  
Human Basal Cell Carcinoma

Hair follicle predetermination

2001 ◽  
Vol 114 (19) ◽  
pp. 3419-3431 ◽  
Author(s):  
Andrei A. Panteleyev ◽  
Colin A. B. Jahoda ◽  
Angela M. Christiano
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Expression Patterns ◽  
Molecular Data ◽  
Hair Shaft ◽  
Outer Root Sheath ◽  
Cellular Kinetics ◽  
Root Sheath ◽  
Bulge Region ◽  
Disc Cells

Recent genetic and molecular studies of hair follicle (HF) biology have provided substantial insight; however, the molecular data, including expression patterns, cannot be properly appreciated without an understanding of the basic cellular rearrangements and interactions that underpin HF cyclic transformations. We present a novel interpretation of the major cellular processes that take place during HF cycling – the hypothesis of hair follicle predetermination. This hypothesis is an extension of previous models of HF cellular kinetics but has two critical modifications: the dual origin of the cycling portion of the HF, and the timing of the recruitment of stem cells. A compilation of evidence suggests that the ascending portion of the HF (hair shaft and inner root sheath) arises not from bulge-located HF stem cells that contribute to the formation of only the outer root sheath (ORS), but instead from the germinative cells localized in the secondary hair germ. In middle anagen, upon completion of the downward growth of the HF, cells derived from the bulge region migrate downward along the ORS to reside at the periphery of the HF bulb as a distinct, inactive cell population that has specific patterns of gene expression - ‘the lateral disc’. These cells survive catagen-associated apoptosis and, under the direct influence of the follicular papilla (FP), transform into the hair germ and acquire the ability to respond to FP signaling and produce a new hair. Thus, we propose that the specific sensitivity of germ cells to FP signaling and their commitment to produce the ascending HF layers are predetermined by the previous hair cycle during the process of transformation of bulge-derived lateral disc cells into the secondary hair germ.

scholarly journals Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

2015 ◽  
Vol 16 (4) ◽  
pp. 400-412 ◽  
Author(s):  
Shelby C. Peterson ◽  
Markus Eberl ◽  
Alicia N. Vagnozzi ◽  
Abdelmadjid Belkadi ◽  
Natalia A. Veniaminova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Basal Cell
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