Oxidative stress as determined by glutathione (GSH) concentrations in venous cord blood in elective cesarean delivery versus uncomplicated vaginal delivery

Background: Mother-infant bonding has tremendous implications for the child's future development. The difficulties that some mothers have in establishing an emotional bond with their newborns often referred to as impaired bonding or bonding failure are an essential focus in the postpartum period. Therefore, it is important to identify predictive factors for bonding failure and to intervene at an early stage for the better mental health care of mothers as well as infant. Objective: To determine the effect of various modes of delivery on the mother-infant bonding. Methods: Prospective observational study performed on low-risk singleton pregnancy who delivered at term. Mother-to-Infant Bonding Scale (MIBS; Taylor et al., 2005), a validated self-report test was used to measure mother's feelings towards her baby within three days of delivery and at the end of six weeks postpartum period. Total score ranges from 0 to 24. A total MIBS score of ≥ 2 is established as cut-off indicating “poor bonding”. MIBS score of 0 and 1 is considered as “good bonding”. The mean bonding score among the 3 groups was compared. Results: Elective cesarean delivery group had 112 participants, 115 were Emergency cesarean group and 107 were vaginal delivery group. Immediately after the delivery (MIBS 1), the proportion of women with poor bonding among Emergency cesarean group was 34.8% when compared to proportion of women with poor bonding among Elective cesarean (11.6%) and Vaginal delivery (13%). This was statistically significant (p-value 0.01). When we followed up these mothers at 6 weeks post-partum checkup, the MIBS scoring (MIBS-2) consistently improved among the three groups. However, proportion of women with poor bonding still remained high at 16.5% among the Emergency cesarean group. Conclusion: Mode of delivery has a significant impact on MIBS. In this study, unplanned cesarean delivery was associated with a high incidence of poor mother to infant bonding. Poor bonding was commoner in this group even at 6 weeks post-partum, compared to those undergoing a successful vaginal delivery and a planned elective cesarean delivery.

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Is vaginal delivery preferable to elective cesarean delivery in fetuses with a known ventral wall defect?

American Journal of Obstetrics and Gynecology ◽

10.1067/mob.2000.106852 ◽

2000 ◽

Vol 182 (6) ◽

pp. 1527-1534 ◽

Cited By ~ 79

Author(s):

Helen Y. How ◽

Brenda Jo Harris ◽

Marcello Pietrantoni ◽

Jennifer C. Evans ◽

Stephanie Dutton ◽

...

Keyword(s):

Cesarean Delivery ◽

Vaginal Delivery ◽

Elective Cesarean Delivery ◽

Wall Defect ◽

Elective Cesarean ◽

Ventral Wall

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A Randomized Controlled Trial of Intact Cord Milking versus Immediate Cord Clamping in Term Infants Born by Elective Cesarean Section

American Journal of Perinatology ◽

10.1055/s-0039-1697673 ◽

2019 ◽

Cited By ~ 1

Author(s):

Vincenzo Zanardo ◽

Pietro Guerrini ◽

Lorenzo Severino ◽

Alphonse Simbi ◽

Matteo Parotto ◽

...

Keyword(s):

Body Weight ◽

Cord Blood ◽

Cesarean Delivery ◽

Controlled Trial ◽

Elective Cesarean Section ◽

Safe Procedure ◽

Elective Cesarean Delivery ◽

Clinical Trial Registration ◽

Cord Clamping ◽

Elective Cesarean

Abstract Objective We evaluated whether intact umbilical cord milking (UCM) is more effective than immediate cord clamping (ICC) in enhancing placental transfusion after elective cesarean delivery. Study Design In a randomized trial, volume of placental transfusion was assessed by Δ hematocrit (Hct) between neonatal cord blood and capillary heel blood at 48 hours of age, corrected for the change in body weight. Results There were no significant differences in cord blood mean Hct values at birth (UCM, 44.5 ± 4.8 vs. ICC, 44.9 ± 4.2%, p = 0.74). Conversely, at 48 hours of age, the UCM group had significantly higher capillary heel Hct values (UCM, 53.7 ± 5.9 vs. ICC, 49.8 ± 4.6%, p < 0.001), supporting a higher placental transfusion volume (Δ Hct, UCM 9.2 ± 5.2 vs. ICC 4.8 ± 4.7, p < 0.001), despite comparable neonatal body weight decrease (UCM, −7.3 vs. ICC, −6.8%, p = 0.77). Conclusion Higher Δ Hct between cord blood at birth and capillary heel blood at 48 hours of age, corrected for the change in body weight, suggests that intact UCM is an efficacious and safe procedure to enhance placental transfusion among neonates born via elective cesarean delivery. Clinical Trial Registration ClinicalTrials.gov, www.clinicaltrials.gov, NCT03668782.

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Comparison of Malondialdehyde Level in the Cord Blood of Newborn Infants of vaginal and cesarean deliveries

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i3.1498 ◽

2019 ◽

Vol 10 (3) ◽

pp. 2487-2494

Author(s):

Eman Khammas ALSaadi ◽

Batol Faisal Taher ◽

Mohammed Abid Darweesh ◽

Mohammed Abul Al-Monther

Keyword(s):

Oxidative Stress ◽

Cesarean Section ◽

Cord Blood ◽

Vaginal Delivery ◽

Oxidative Stress Marker ◽

Elective Cesarean Section ◽

Stress Injury ◽

Vaginal Deliveries ◽

Two Samples ◽

Elective Cesarean

The oxidative stress injury that has been linked to poor perinatal outcome and birth asphyxia may be found even with normal pregnancy, and it is severity in a newborn may be related to modes of delivery for which our study aimed to identify. Furthermore, this study was aimed to study the effect of both related- maternal, and related neonatal characteristics on baby’s oxidative stress marker level (Malondialdehyde). Fifty newborn children were selected in both labor ward and operating theatre of Al-Sadder Teaching Hospital, Misan, Iraq. They were divided into two groups. The first group comprised 28 newborns, who were born by a vaginal delivery; the second group consisted of 22 newborns who delivered by elective cesarean section. The laboratory measurement of levels of an important antioxidant factor [malondialdehyde (MDA)] in baby’s cord blood has been extracted and used as an indicator of stress. We compared the two samples of different malondialdehyde levels in relation to variables as the delivery type, some maternal, fetal and neonatal characteristics. The results of this study revealed that MDA level was higher among neonates delivered through Elective Cesareans Section than those delivered through Vaginal Delivery with significant statistical value (p>0.0001). The previous delivery mood has a statistically significant value of (p>0.02) among mothers who had no previous deliveries. While there were no significant statistical values regarding maternal characteristics as (ages, parity, residency, antenatal care, history of previous abortion, and body mass index) as well as fetal and neonatal characteristics as (sex, birth weight, fetal presentation, and Apgar score) and high MDA level. The current study was concluded that babies delivered by Elective Cesarean Section had been exposed to more oxidative stress compared to the normal Vaginal Deliveries especially for the Primigravidas.

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