Malignant pericardial effusion with cardiac tamponade in ovarian adenocarcinoma

2009 ◽  
Vol 280 (4) ◽  
pp. 675-678 ◽  
Author(s):  
Emily E. Petersen ◽  
Alireza A. Shamshirsaz ◽  
Theresa M. Brennan ◽  
Elaine M. Demetroulis ◽  
Michael J. Goodheart
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Ovarian Adenocarcinoma ◽  
Malignant Pericardial Effusion

scholarly journals Malignant pericardial effusion complicated by cardiac tamponade under atezolizumab

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110360
Author(s):  
Lardinois Benjamin ◽  
Goeminne Jean-Charles ◽  
Miller Laurence ◽  
Randazzo Adrien ◽  
Laurent Terry ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Cardiac Toxicity ◽  
Checkpoint Inhibitors ◽  
Final Diagnosis ◽  
Pericardial Fluid ◽  
Malignant Pericardial Effusion ◽  
Typical Cell ◽  
High Fluorescence ◽  
Tomography Scan

Immune-related adverse events including cardiac toxicity are increasingly described in patients receiving immune checkpoint inhibitors. We described a malignant pericardial effusion complicated by a cardiac tamponade in an advanced non-small cell lung cancer patient who had received five infusions of atezolizumab, a PDL-1 monoclonal antibody, in combination with cabozantinib. The definitive diagnosis was quickly made by cytology examination showing typical cell abnormalities and high fluorescence cell information provided by the hematology analyzer. The administration of atezolizumab and cabozantinib was temporarily discontinued due to cardiogenic hepatic failure following cardiac tamponade. After the re-initiation of the treatment, pericardial effusion relapsed. In this patient, the analysis of the pericardial fluid led to the final diagnosis of pericardial tumor progression. This was afterwards confirmed by the finding of proliferating intrapericardial tissue by computed tomography scan and ultrasound. This report emphasizes the value of cytology analysis performed in a hematology laboratory as an accurate and immediate tool for malignancy detection in pericardial effusions.

Unsuspected Malignant Pericardial Effusion Causing Cardiac Tamponade

CHEST Journal ◽  
1982 ◽  
Vol 82 (4) ◽  
pp. 501-503 ◽  
Author(s):  
Frank E. Johnson ◽  
Michael K. Wolverson ◽  
Murali Sundaram ◽  
Elisabeth Heiberg
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Malignant Pericardial Effusion

Malignant Pericardial Effusion and Cardiac Tamponade in Endometrial Adenocarcinoma

2001 ◽  
Vol 83 (1) ◽  
pp. 143-145 ◽  
Author(s):  
Pankaj Kheterpal ◽  
Manoj Singh ◽  
Abdul Mondul ◽  
Lekshmi Dharmarajan ◽  
Anita Soni
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Endometrial Adenocarcinoma ◽  
Malignant Pericardial Effusion

Malignant pericardial effusion with cardiac tamponade in a patient with metastatic vaginal adenocarcinoma

2006 ◽  
Vol 16 (3) ◽  
pp. 1458-1461 ◽  
Author(s):  
N. P. Nagarsheth ◽  
M. Harrison ◽  
T. Kalir ◽  
J. Rahaman
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Lung Metastases ◽  
Gynecological Cancer ◽  
Disease Process ◽  
Surgical Excision ◽  
Clear Cell Adenocarcinoma ◽  
Pericardial Window ◽  
Malignant Pericardial Effusion ◽  
Platinum Based Chemotherapy

Malignant pericardial effusion with cardiac tamponade is a rare manifestation of metastatic gynecological cancer. A 35-year-old female was diagnosed with clear cell adenocarcinoma of the vagina. Four years after partial vaginectomy, she developed regional recurrence and was treated with surgical excision followed by platinum-based chemotherapy and radiation therapy. Six years later, the patient was diagnosed with lung metastases and received a combination adriamycin and platinum-based chemotherapy. Shortly after completing treatment, she presented with weakness and was found to be hypotensive on physical exam. Computed tomography scan confirmed a pericardial effusion with evidence of bilateral heart failure. She underwent an emergent pericardiocentesis and eventual pericardial window procedure. Metastatic adenocarcinoma of the vagina can present with malignant pericardial effusion with cardiac tamponade. Therefore, gynecologists and gynecological oncologists need to be familiar with the diagnosis and management of this disease process.

Intrapericardial tetracycline sclerosis in the treatment of malignant pericardial effusion: an analysis of thirty-three cases.

1984 ◽  
Vol 2 (6) ◽  
pp. 631-636 ◽  
Author(s):  
S Davis ◽  
P Rambotti ◽  
F Grignani
Keyword(s):  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Performance Status ◽  
Signs And Symptoms ◽  
Pericardial Fluid ◽  
Complete Control ◽  
Malignant Pericardial Effusion ◽  
Efficacious Treatment ◽  
Clinically Significant ◽  
Premature Removal

Thirty-three unselected patients with cardiac tamponade secondary to malignant pericardial effusion were treated by intrapericardial instillation of tetracycline hydrochloride. Complete control of the initial signs and symptoms of tamponade was obtained in 30 patients without concomitant chemotherapy or radiotherapy. The procedure did not result in clinically significant complications. Failure of the technique was related to premature removal of the catheter by the patient (one patient) or the inability to totally remove hemorrhagic, clot-filled pericardial fluid (two patients). Survival ranged between 28-704 days and extended survival was related to the performance status and/or chemoradiosensitivity of the primary cancer. No patient successfully treated subsequently developed recurrent cardiac tamponade or alternatively, constrictive pericarditis. Tetracycline pericardial instillation remains a safe, simple, and efficacious treatment of tamponade secondary to malignant disease.

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