Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour

2011 ◽  
Vol 261 (8) ◽  
pp. 533-538 ◽  
Author(s):  
Crystal Pinto ◽  
Renan P. Souza ◽  
Diane Lioult ◽  
Mawahib Semeralul ◽  
James L. Kennedy ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Suicidal Behaviour ◽  
Allelic Expression ◽  
Allelic Expression Imbalance ◽  
Parent Of Origin ◽  
Origin Effect

Parent of origin effect and differential allelic expression of BDNF Val66Met in suicidal behaviour

2010 ◽  
Vol 12 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Vincenzo de Luca ◽  
Renan P. Souza ◽  
Clement C. Zai ◽  
Fabio Panariello ◽  
Naima Javaid ◽  
...  
Keyword(s):  
Suicidal Behaviour ◽  
Allelic Expression ◽  
Differential Allelic Expression ◽  
Parent Of Origin ◽  
Origin Effect

scholarly journals Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance

2007 ◽  
Vol 12 (5) ◽  
pp. 421-422 ◽  
Author(s):  
J Martin ◽  
J Cleak ◽  
S A G Willis-Owen ◽  
J Flint ◽  
S Shifman
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Allelic Expression ◽  
Transporter Gene ◽  
Allelic Expression Imbalance ◽  
Regulatory Variants

Association study of a novel functional polymorphism of the serotonin transporter gene in bipolar disorder and suicidal behaviour

2005 ◽  
Vol 182 (1) ◽  
pp. 128-131 ◽  
Author(s):  
Vincenzo De Luca ◽  
Subi Tharmalingam ◽  
Nicole King ◽  
John Strauss ◽  
Natalie Bulgin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Serotonin Transporter ◽  
Suicidal Behaviour ◽  
Serotonin Transporter Gene ◽  
Functional Polymorphism ◽  
Transporter Gene

Parent-of-origin effect in transmission of bipolar disorder

1996 ◽  
Vol 67 (6) ◽  
pp. 546-550 ◽  
Author(s):  
Tadafumi Kato ◽  
George Winokur ◽  
William Coryell ◽  
Martin B. Keller ◽  
Jean Endicott ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Parent Of Origin ◽  
Origin Effect

Evidence for linkage of bipolar disorder to HC 18 with a parent-of-origin effect

1996 ◽  
Vol 39 (7) ◽  
pp. 539
Author(s):  
O.C. Stine ◽  
J. Xu ◽  
R. Koskela ◽  
F.J. McMahon ◽  
M. Gschwend ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Parent Of Origin ◽  
Origin Effect

scholarly journals Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. VOLUME 280 (2005) PAGES 32618-32624

2005 ◽  
Vol 280 (46) ◽  
pp. 38888
Author(s):  
Ying Zhang ◽  
Danxin Wang ◽  
Andrew D. Johnson ◽  
Audrey C. Papp ◽  
Wolfgang Sadée
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Allelic Expression ◽  
Allelic Expression Imbalance ◽  
Mu Opioid

Allelic expression imbalance refined genome-wide association signals in osteoarthritis

2021 ◽  
Vol 29 ◽  
pp. S313
Author(s):  
R.C. de Almeida ◽  
W. Den Hollander ◽  
R.R. Nelissen ◽  
L. Mei ◽  
I. Meulenbelt
Keyword(s):  
Genome Wide Association ◽  
Allelic Expression ◽  
Allelic Expression Imbalance ◽  
Genome Wide

scholarly journals Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tempei Ikegame ◽  
Yosuke Hidaka ◽  
Yutaka Nakachi ◽  
Yui Murata ◽  
Risa Watanabe ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Psychiatric Disorders ◽  
Serotonin Transporter ◽  
Tandem Repeats ◽  
Large Population ◽  
Functional Characterization ◽  
Luciferase Assay ◽  
Elderly Subjects ◽  
Polymorphic Region ◽  
Rare Alleles

AbstractSLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each of which has 14 or 16 tandem repeats. In addition, the extralong (XL) and other rare alleles have been reported in 5-HTTLPR. Although they are more frequent in Asian and African than in other populations, the extent of variations and allele frequencies (AFs) were not addressed in a large population. Here, we report the AFs of the rare alleles in a large number of Japanese subjects (N = 2894) consisting of two cohorts. The first cohort (case-control study set, CCSS) consisted of 1366 subjects, including 485 controls and 881 patients with psychosis (bipolar disorder or schizophrenia). The second cohort (the Arao cohort study set, ACSS) consisted of 1528 elderly subjects. During genotyping, we identified 11 novel 5-HTTLPR alleles, including 3 XL alleles. One novel allele had the longest subunit ever reported, consisting of 28 tandem repeats. We named this XL28-A. An in vitro luciferase assay revealed that XL28-A has no transcriptional activity. XL28-A was found in two unrelated patients with bipolar disorder in the CCSS and one healthy subject in the ACSS who did not show depressive symptoms or a decline in cognitive function. Therefore, it is unlikely that XL28-A is associated with psychiatric disorders, despite its apparent functional deficit. Our results suggest that unraveling the complex genetic variations of 5-HTTLPR will be important for further understanding its role in psychiatric disorders.

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