Postmortem genetic testing should be recommended in sudden cardiac death cases due to thoracic aortic dissection

2017 ◽  
Vol 131 (5) ◽  
pp. 1211-1219 ◽  
Author(s):  
Marina Gago-Díaz ◽  
Eva Ramos-Luis ◽  
Silvia Zoppis ◽  
Esther Zorio ◽  
Pilar Molina ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Aortic Dissection ◽  
Cardiac Death ◽  
Thoracic Aortic Dissection ◽  
Death Cases ◽  
Postmortem Genetic Testing

Postmortem genetic testing in sudden death cases

ESC CardioMed ◽  
2018 ◽  
pp. 685-688
Author(s):  
Najim Lahrouchi ◽  
Elijah R. Behr ◽  
Connie R. Bezzina
Keyword(s):  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Cardiac Disease ◽  
Cardiac Death ◽  
Arrhythmic Death ◽  
Sudden Unexplained Death ◽  
Unexplained Death ◽  
Sudden Arrhythmic Death Syndrome ◽  
Death Cases ◽  
Postmortem Genetic Testing

Postmortem analysis of young sudden cardiac death patients leads to a diagnosis of structural cardiac disease in the majority of cases. However, despite thorough autopsy, including toxicological and histological analysis, in one-third of patients no cause of death is identified and these patients are classified as sudden unexplained death or sudden arrhythmic death syndrome. Postmortem genetic testing in these patients can establish a genetic aetiology of sudden cardiac death, which allows for appropriate screening and management of family members at risk of sudden cardiac death.

Postmortem genetic testing in sudden cardiac death: To be or not to be?

2018 ◽  
Vol 280 ◽  
pp. S19
Author(s):  
Sehime Gulsun Temel ◽  
Burcu Turkgenc ◽  
Arzu Akcay ◽  
Aylin Koseler ◽  
Cengiz Yakicier
Keyword(s):  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Postmortem Genetic Testing

scholarly journals Global approaches to postmortem genetic testing after sudden cardiac death in the young: A survey among healthcare professionals

2020 ◽  
Author(s):  
Lieke M. van den Heuvel ◽  
Judy Do ◽  
Laura Yeates ◽  
Heather MacLeod ◽  
Cynthia A. James ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Healthcare Professionals ◽  
Professional Associations ◽  
Financial Resources ◽  
Multidisciplinary Teams ◽  
Testing Practices ◽  
Postmortem Genetic Testing

ABSTRACTPurposeThorough investigation of sudden cardiac death (SCD) in those aged 1-40 years commonly reveals a heritable cause, yet access to postmortem genetic testing is variable. We explore practices of postmortem genetic testing and attitudes of healthcare professionals worldwide.MethodsA survey was administered among healthcare professionals recruited through professional associations, social media and networks of researchers. Topics included practices around postmortem genetic testing, level of confidence in healthcare professionals’ ability, and attitudes towards postmortem genetic testing practices.ResultsThere were 112 respondents, with 93% from North America, Europe and Australia and 7% from South America, Asia and Africa. Only 30% reported autopsy as mandatory, and overall practices were largely case-by-case and not standardised. North American respondents (87%) more often perceived practices as ineffective compared to those from Europe (58%) and Australia/New Zealand (48%, p=0.002). Where a heritable cause is suspected, 69% considered postmortem genetic testing and 61% offered genetic counseling to surviving family members; financial resources varied widely. Half believed practices in their countries perpetuated health inequalities.ConclusionPostmortem genetic testing is not consistently available in the investigation of young SCD despite being a recommendation in international guidelines. Access to postmortem genetic testing, guided by well-resourced multidisciplinary teams, is critical in ascertaining a cause of death in many cases.

scholarly journals 0486: Postmortem genetic testing in a series of 36 young patients after sudden cardiac death

2015 ◽  
Vol 7 (1) ◽  
pp. 28
Author(s):  
Isabelle Marey ◽  
Véronique Fressart ◽  
Caroline Rambaud ◽  
Estelle Gandjbakhch ◽  
Elsa Le Boette ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Young Patients ◽  
Postmortem Genetic Testing

scholarly journals European recommendations integrating genetic testing into multidisciplinary management of sudden cardiac death

2019 ◽  
Vol 27 (12) ◽  
pp. 1763-1773 ◽  
Author(s):  
Florence Fellmann ◽  
◽  
Carla G. van El ◽  
Philippe Charron ◽  
Katarzyna Michaud ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Multidisciplinary Management

scholarly journals Motivation to Pursue Genetic Testing in Individuals with a Personal or Family History of Cardiac Events or Sudden Cardiac Death

2014 ◽  
Vol 23 (5) ◽  
pp. 849-859 ◽  
Author(s):  
Kathleen E. Erskine ◽  
Nadia Z. Hidayatallah ◽  
Christine A. Walsh ◽  
Thomas V. McDonald ◽  
Lilian Cohen ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Family History ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Cardiac Events ◽  
History Of
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