Integrated Hydraulic Fracturing and Well-Test Data Analytics using R

1. Abstract Various datasets are generated during hydraulic fracturing, flowback- and well-testing operations, which require consistent integration to lead to high-quality well performance interpretations. An automated digital workflow has been created to integrate and analyze the data in a consistent manner using the open-source programming language R. This paper describes the workflow, and it explains how it automatically generates well performance models and how it analyzes raw diagnostic fracture injection test (DFIT) data using numerical algorithms and Machine Learning. This workflow is successfully applied in a concession area located in the center of the Sultanate of Oman, where to date a total of 25+ tight gas wells are drilled, hydraulically fractured and well-tested. It resulted in an automated and standardized way of working, which enabled identifying trends leading to improved hydraulic fracturing and well-testing practices.

Mainstreaming Genetic Testing for Epithelial Ovarian Cancer by Oncology Providers: A Survey of Current Practice

PURPOSE With limitations in early detection and poor treatment response, ovarian cancer is associated with significant morbidity and mortality. Up to 25% of epithelial ovarian cancer (EOC) is related to a hereditary predisposition. Current National Comprehensive Cancer Network guidelines recommend that all individuals diagnosed with EOC be offered germline genetic testing. Although this would ideally be performed by genetics professionals, a shortage of genetic counselors can affect timely access to these services. This study sought to investigate the current genetic testing practices of oncology providers to determine the feasibility of oncologist-led genetic testing for patients with EOC. METHODS A survey was distributed to members of the Society of Gynecologic Oncologists with questions regarding timing, frequency, and type of cancer genetic testing, referrals to genetics professionals, confidence with aspects of genetic testing, and any barriers to these processes. RESULTS We received 170 evaluable responses. Eighty-five percent of providers always ordered genetic testing for patients with EOC. Most providers ordered germline multigene panel testing (95.8%), generally at diagnosis (64.5%). Provider confidence with the genetic testing process was generally high and significantly differed by providers' testing practices, namely, respondents who reported always ordering genetic testing tended to be more confident in ordering testing ( P = .008), interpreting results ( P = .005), and counseling a patient ( P = .002). Patient disinterest and concerns for insurance coverage were commonly cited as barriers to testing and referrals. CONCLUSION The findings from this study suggest that oncologist-led genetic testing for patients with EOC, with referrals to genetics professionals when appropriate, has the potential to be a viable alternative service delivery model to increase access to genetic testing for patients diagnosed with EOC.

Crossing Borders, Writing Texts, Being Evaluated

This book examines both writing norms and assessment, and proficiency development, and suggests that scholars need to critically examine testing regimes and develop research-based perspectives on tests and testing practices, so that educational institutions can prepare learners with differing cultural experiences for tests and assessments.

Discourse Analysis in Second Language Speaking Assessment

Discourse analysis has been widely used in the field of language testing. This chapter provides an overview of research examining features of test-taker discourse across different task types and under different task conditions and the extent to which these features align with rating scale criteria. Attention is also drawn to discourse analytic studies of the language demands of study and work domains and the extent to which test tasks can elicit relevant features. The chapter concludes by reflecting on the challenges posed to existing high-stakes test constructs by increasing diversity in universities and workplaces and the potential for discourse analytic approaches to establish stronger alignments between testing practices and the aspects of spoken discourse relevant and valued in communication.

Pharmacogenomic testing and prescribing patterns for patients with cancer in a large national precision medicine cohort

Population databases could help patients with cancer and providers better understand current pharmacogenomic prescribing and testing practices. This retrospective observational study analysed patients with cancer, drugs with pharmacogenomic evidence and related genetic testing in the National Institutes of Health All of Us database. Most patients with cancer (19 633 (88.3%) vs 2590 (11.7%)) received ≥1 drug and 36 (0.2%) received genetic testing, with a significant association between receiving ≥1 drug and age group (p<0.001), but not sex (p=0.612), race (p=0.232) or ethnicity (p=0.971). Drugs with pharmacogenomic evidence—but not genetic testing—were common for patients with cancer, reflecting key gaps preventing precision medicine from becoming standard of care.

Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review

Background Thrombophilia workup is typically inappropriate in the inpatient setting as testing may be skewed by anticoagulation, acute thrombosis, or acute illness. Objective To determine adherence of inpatient thrombophilia testing with institutional guidelines. Patients and methods A retrospective study to evaluate thrombophilia testing practices of adult patients who were admitted to Lehigh Valley Hospital at Cedar Crest with either venous thromboembolism or ischemic stroke in 2019. Testing included inherited and acquired thrombophilia. Patient charts were individually reviewed for three measured outcomes: 1) the number of appropriate thrombophilia testing in the inpatient setting; 2) the indications used for thrombophilia testing; 3) the proportion of positive thrombophilia tests with change in clinical management. Results 201 patients were included in our study. 26 patients (13%) were tested appropriately in accordance with institution guidelines and 175 (87%) patients were tested inappropriately. The most common reason for the inappropriate testing was testing during acute thrombosis. 28 of the 201 patients had positive thrombophilia tests, but the reviewers only noted 7 patients with change in clinical management—involving anticoagulation change. Conclusion Our study revealed that a majority of inpatient thrombophilia testing did not follow institutional guidelines for appropriate testing and did not change patient management. These thrombophilia tests are often overutilized and have minimal clinical utility in the inpatient setting.