Accuracy of perfusion-CT inpredicting malignant middle cerebral artery brain infarction

2008 ◽  
Vol 255 (6) ◽  
pp. 896-902 ◽  
Author(s):  
R. Dittrich ◽  
S. P. Kloska ◽  
T. Fischer ◽  
E. Nam ◽  
M. A. Ritter ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Brain Infarction ◽  
Perfusion Ct

A review of the anatomy of the middle cerebral artery for the era of thrombectomy: A radiologic tool based on CT angiography and perfusion CT

2021 ◽  
Vol 63 (6) ◽  
pp. 505-511
Author(s):  
S. Medrano-Martorell ◽  
M. Pumar-Pérez ◽  
S. González-Ortiz ◽  
J. Capellades-Font
Keyword(s):  
Middle Cerebral Artery ◽  
Ct Angiography ◽  
Cerebral Artery ◽  
Perfusion Ct

Assessment of Collateral Circulation Using Perfusion CT in Middle Cerebral Artery Thrombectomy-Treated Patients

2020 ◽  
Vol 29 (7) ◽  
pp. 104805
Author(s):  
Santiago Trillo ◽  
María Carmen Ramos ◽  
Clara Aguirre ◽  
José Luis Caniego ◽  
Eduardo Bárcena ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Collateral Circulation ◽  
Perfusion Ct

scholarly journals Optimal Brain Perfusion CT Coverage in Patients with Acute Middle Cerebral Artery Stroke

2009 ◽  
Vol 31 (4) ◽  
pp. 691-695 ◽  
Author(s):  
A.D. Furtado ◽  
B.C. Lau ◽  
E. Vittinghoff ◽  
W.P. Dillon ◽  
W.S. Smith ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Brain Perfusion ◽  
Perfusion Ct ◽  
Middle Cerebral Artery Stroke

scholarly journals Prediction of Malignant Middle Cerebral Artery Infarction Using Computed Tomography-Based Intracranial Volume Reserve Measurements

Stroke ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. 3403-3409 ◽  
Author(s):  
Jens Minnerup ◽  
Heike Wersching ◽  
E. Bernd Ringelstein ◽  
Walter Heindel ◽  
Thomas Niederstadt ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Predictive Value ◽  
Perfusion Ct ◽  
Lesion Volume ◽  
Intracranial Volume ◽  
Ischemic Lesion ◽  
Predictive Values ◽  
Malignant Infarction ◽  
Malignant Mca Infarction

Background and Purpose— Early decompressive surgery in patients with malignant middle cerebral artery (MCA) infarction improves outcome. Elevation of intracranial pressure depends on both the space occupying brain edema and the intracranial volume reserve (cerebrospinal fluid [CSF]). However, CSF volume was not investigated as a predictor of malignant infarction so far. We hypothesize that assessment of CSF volume in addition to admission infarct size improves early prediction of malignant MCA infarction. Methods— Stroke patients with carotid-T or MCA main stem occlusion and ischemic lesion (reduced cerebral blood volume [CBV]) on perfusion CT were considered for the analysis. The end point malignant MCA infarction was defined by clinical signs of herniation. Volumes of CSF and CBV lesion were determined on admission. Receiver-operator characteristics analysis was used to calculate predictive values for radiological and clinical measurements. Results— Of 52 patients included, 26 (50%) developed malignant MCA infarction. Age, a decreased level of consciousness on admission, CBV lesion volume, CSF volume, and the ratio of CBV lesion volume to CSF volume were significantly different between malignant and nonmalignant groups. The best predictor of a malignant course was the ratio of CBV lesion volume to CSF volume with a cut-off value of 0.92 (96.2% sensitivity, 96.2% specificity, 96.2% positive predictive value, and 96.2% negative predictive value). Conclusions— Based on admission native CT and perfusion CT measurements, the ratio of ischemic lesion volume to CSF volume predicts the development of malignant MCA infarction with higher accuracy than other known predictors, including ischemic lesion volume or clinical characteristics.

scholarly journals Cerebroprotective Effect ofMoringa oleiferaagainst Focal Ischemic Stroke Induced by Middle Cerebral Artery Occlusion

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Woranan Kirisattayakul ◽  
Jintanaporn Wattanathorn ◽  
Terdthai Tong-Un ◽  
Supaporn Muchimapura ◽  
Panakaporn Wannanon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Protective Effect ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Brain Infarction ◽  
Artery Occlusion ◽  
High Dose ◽  
Infarction Volume ◽  
Male Wistar Rats

The protection against ischemic stroke is still required due to the limitation of therapeutic efficacy. Based on the role of oxidative stress in stroke pathophysiology, we determined whetherMoringa oleifera, a plant possessing potent antioxidant activity, protected against brain damage and oxidative stress in animal model of focal stroke.M. oleiferaleaves extract at doses of 100, 200 and 400 mg·kg−1was orally given to male Wistar rats (300–350 g) once daily at a period of 2 weeks before the occlusion of right middle cerebral artery (Rt.MCAO) and 3 weeks after Rt.MCAO. The determinations of neurological score and temperature sensation were performed every 7 days throughout the study period, while the determinations of brain infarction volume, MDA level, and the activities of SOD, CAT, and GSH-Px were performed 24 hr after Rt.MCAO. The results showed that all doses of extract decreased infarction volume in both cortex and subcortex. The protective effect of medium and low doses of extract in all areas occurred mainly via the decreased oxidative stress. The protective effect of the high dose extract in striatum and hippocampus occurred via the same mechanism, whereas other mechanisms might play a crucial role in cortex. The detailed mechanism required further exploration.

Abstract T P82: Long-Term Neurorestorative Effect of α-lipoic Acid Treatment in Focal Cerebral Ischemia Model

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Kangho Choi ◽  
Joon-Tae Kim ◽  
Man-Seok Park ◽  
Ki-Hyun Cho
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Lipoic Acid ◽  
Focal Cerebral Ischemia ◽  
Brain Infarction ◽  
Antioxidant Properties ◽  
Ischemic Injury ◽  
Control Group ◽  
Rotarod Test

Introduction: A considerable body of evidence suggests that oxidative stress is a fundamental mechanism of brain damage in stroke. A recent study suggests that the antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no reports of comprehensive studies examining the neurorestorative effects of aLA administered after the onset of ischemia. Hypothesis: The neuroprotective effects of acute treatment with ALA on neuroproliferation and long-term functional recovery following cerebral ischemic injury were examined using an animal model of clinical stroke with middle cerebral artery occlusion (MCAO). Methods: The middle cerebral artery (MCA) of adult male Sprague-Dawley rats was occluded for 2 h and then reperfused. To examine the effect of ALA on brain infarction, ALA (20 mg/kg body weight) was administered after the induction of anesthesia in 71 animals (ALA group) through the left external jugular vein immediately after reperfusion of the left MCAO. An equivalent volume of vehicle was administrated to 71 animals (control group) using the same procedure. A neurologic examination was performed at defined points after MCAO and a neurological deficit score (NDS) was obtained. Motor impairment was assessed by the accelerating rotarod test. Levels of endogenous neural precursor and glial cell were analyzed by immunohistochemistry. Results: Immediate aLA administration group after reperfusion significantly reduced the mortality, infarct size, and NDS than control group (n=71, P=0.005, P=0.002, and P=0.001, respectively). Long-term functional outcomes by Rotarod test were also markedly improved by aLA treatment (P=0.013). After 7 and 14 days of treatment, significantly more cells were labeled with BrdU, nestin, and GFAP in the aLA-treated rats along the infarct and infarct core regions. Significantly more BrdU/GFAP double-labeled cells were observed in the subventricular zone of the aLA group on days 7 and 14. Conclusions: These results indicate that urgent treatment with aLA after ischemic injury may have significant neurorestorative effects through enhanced neuroproliferation. aLA may be a useful intervention for the treatment of acute ischemic stroke.

Spontaneous dissecting aneurysms of anterior and middle cerebral artery associated with brain infarction

2002 ◽  
Vol 57 (6) ◽  
pp. 428-436 ◽  
Author(s):  
Masahito Kurino ◽  
Susumu Yoshioka ◽  
Yukitaka Ushio
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Brain Infarction ◽  
Dissecting Aneurysms

scholarly journals Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

2009 ◽  
Vol 16 (1) ◽  
pp. 9 ◽  
Author(s):  
Yi Chang ◽  
Cheng-Ying Hsieh ◽  
Zi-Aa Peng ◽  
Ting-Lin Yen ◽  
George Hsiao ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Brain Infarction ◽  
Artery Occlusion ◽  
Cerebral Artery Occlusion
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