Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II

1997 ◽  
Vol 107 (3) ◽  
pp. 193-203 ◽  
Author(s):  
Leo T. M. Van der Ven ◽  
Paul J. M. Roholl ◽  
Maria G. Reijnen-Gresnigt ◽  
Ruud J. Bloemen ◽  
Sylvia C. van Buul-Offers
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Insulin Like Growth Factor ◽  
Histological Changes ◽  
Factor Ii

scholarly journals Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 ◽  
Vol 269 (19) ◽  
pp. 13779-13784 ◽  
Author(s):  
C.E. Rogler ◽  
D. Yang ◽  
L. Rossetti ◽  
J. Donohoe ◽  
E. Alt ◽  
...  
Keyword(s):  
Body Composition ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice

1991 ◽  
Vol 13 (2) ◽  
pp. 220-226 ◽  
Author(s):  
Elisabetta Cariani ◽  
Nathalie Dubois ◽  
Chantal Lasserre ◽  
Pascale Briand ◽  
Christian Brechot
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Mrna Expression ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Postnatal Overexpression of Insulin-Like Growth Factor II in Transgenic Mice Is Associated with Adrenocortical Hyperplasia and Enhanced Steroidogenesis1

Endocrinology ◽  
1999 ◽  
Vol 140 (4) ◽  
pp. 1537-1543 ◽  
Author(s):  
Matthias M. Weber ◽  
Christian Fottner ◽  
Peter Schmidt ◽  
Kathrin M. H. Brodowski ◽  
Katinka Gittner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Adrenocortical Hyperplasia

Decreased skin sensory innervation in transgenic mice overexpressing insulin-like growth factor-II

Neuroscience ◽  
1997 ◽  
Vol 79 (3) ◽  
pp. 789-797 ◽  
Author(s):  
M.L Reynolds ◽  
A Ward ◽  
C.F Graham ◽  
R Coggeshall ◽  
M Fitzgerald
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Sensory Innervation ◽  
Insulin Like Growth Factor ◽  
Factor Ii

High plasma insulin-like growth factor-II and low lipid content in transgenic mice: measurements of lipid metabolism

1994 ◽  
Vol 143 (3) ◽  
pp. 433-439 ◽  
Author(s):  
T H M Da Costa ◽  
D H Williamson ◽  
A Ward ◽  
P Bates ◽  
R Fisher ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Brown Adipose Tissue ◽  
Lipid Content ◽  
Whole Body ◽  
Insulin Like Growth Factor ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Factor Ii

Abstract Transgenic mice were made by introducing extra copies of the mouse insulin-like growth factor-II (IGF-II) gene driven by the bovine keratin 10 promoter (BKVI). The adult plasma IGF-II levels were elevated at least three times in one line. In this line, there was a lower lipid content of both brown and white adipose depots at 2–4 months of age, and 40% less fat in the carcass at 7–9 months. The low lipid phenotype was not detected in the carcass at 2 weeks after birth. The lean characteristic was attributed to circulating IGF-II because the transgene was not expressed in fat. At 2–4 months of age, the transgenes oxidized more oral lipid, and less of this lipid was incorporated into the whole body and the epididymal fat. In contrast, the interscapular brown adipose tissue maintained lipid incorporation and lipoprotein lipase activity despite its reduced size. The altered activity of the brown adipose tissue may account for the gradual onset and persistence of the lean feature of the transgenic mice. There were no substantial changes in lipogenesis which could account for the low fat content. The plasma levels of IGF-I, insulin, glycerol, non-esterified fatty acids, triacylglycerols and glucose were not greatly changed and the pituitary GH content was within the normal range. Journal of Endocrinology (1994) 143, 433–439

Abnormal Thymic Microenvironment in Insulin-Like Growth Factor-II Transgenic Mice

2005 ◽  
Vol 12 (2) ◽  
pp. 100-112 ◽  
Author(s):  
Wilson Savino ◽  
Vinícius Cotta-de-Almeida ◽  
Sylvia C. van Buul-Offers ◽  
Johanna G. Koster ◽  
Mireille Dardenne
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 ◽  
Vol 72 (5) ◽  
pp. 1189-1193 ◽  
Author(s):  
P Bates ◽  
R Fisher ◽  
A Ward ◽  
L Richardson ◽  
DJ Hill ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Mammary Cancer ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1

2015 ◽  
Vol 53 (3) ◽  
pp. 249-258 ◽  
Author(s):  
Katarzyna Piotrowska ◽  
Sylwia Sluczanowska-Glabowska ◽  
Magda Kucia ◽  
Andrzej Bartke ◽  
Maria Laszczynska ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Plasma Level ◽  
Transgenic Mice ◽  
High Plasma ◽  
Insulin Like Growth Factor ◽  
Histological Changes ◽  
High Plasma Level
Sign in / Sign up

Export Citation Format

Share Document