scholarly journals Postnatal Overexpression of Insulin-Like Growth Factor II in Transgenic Mice Is Associated with Adrenocortical Hyperplasia and Enhanced Steroidogenesis1

Endocrinology ◽  
1999 ◽  
Vol 140 (4) ◽  
pp. 1537-1543 ◽  
Author(s):  
Matthias M. Weber ◽  
Christian Fottner ◽  
Peter Schmidt ◽  
Kathrin M. H. Brodowski ◽  
Katinka Gittner ◽  
...  
1994 ◽  
Vol 269 (19) ◽  
pp. 13779-13784 ◽  
Author(s):  
C.E. Rogler ◽  
D. Yang ◽  
L. Rossetti ◽  
J. Donohoe ◽  
E. Alt ◽  
...  

1991 ◽  
Vol 13 (2) ◽  
pp. 220-226 ◽  
Author(s):  
Elisabetta Cariani ◽  
Nathalie Dubois ◽  
Chantal Lasserre ◽  
Pascale Briand ◽  
Christian Brechot

Neuroscience ◽  
1997 ◽  
Vol 79 (3) ◽  
pp. 789-797 ◽  
Author(s):  
M.L Reynolds ◽  
A Ward ◽  
C.F Graham ◽  
R Coggeshall ◽  
M Fitzgerald

1994 ◽  
Vol 143 (3) ◽  
pp. 433-439 ◽  
Author(s):  
T H M Da Costa ◽  
D H Williamson ◽  
A Ward ◽  
P Bates ◽  
R Fisher ◽  
...  

Abstract Transgenic mice were made by introducing extra copies of the mouse insulin-like growth factor-II (IGF-II) gene driven by the bovine keratin 10 promoter (BKVI). The adult plasma IGF-II levels were elevated at least three times in one line. In this line, there was a lower lipid content of both brown and white adipose depots at 2–4 months of age, and 40% less fat in the carcass at 7–9 months. The low lipid phenotype was not detected in the carcass at 2 weeks after birth. The lean characteristic was attributed to circulating IGF-II because the transgene was not expressed in fat. At 2–4 months of age, the transgenes oxidized more oral lipid, and less of this lipid was incorporated into the whole body and the epididymal fat. In contrast, the interscapular brown adipose tissue maintained lipid incorporation and lipoprotein lipase activity despite its reduced size. The altered activity of the brown adipose tissue may account for the gradual onset and persistence of the lean feature of the transgenic mice. There were no substantial changes in lipogenesis which could account for the low fat content. The plasma levels of IGF-I, insulin, glycerol, non-esterified fatty acids, triacylglycerols and glucose were not greatly changed and the pituitary GH content was within the normal range. Journal of Endocrinology (1994) 143, 433–439


2005 ◽  
Vol 12 (2) ◽  
pp. 100-112 ◽  
Author(s):  
Wilson Savino ◽  
Vinícius Cotta-de-Almeida ◽  
Sylvia C. van Buul-Offers ◽  
Johanna G. Koster ◽  
Mireille Dardenne

1995 ◽  
Vol 72 (5) ◽  
pp. 1189-1193 ◽  
Author(s):  
P Bates ◽  
R Fisher ◽  
A Ward ◽  
L Richardson ◽  
DJ Hill ◽  
...  

2000 ◽  
Vol 105 (6) ◽  
pp. 731-740 ◽  
Author(s):  
Jean-Christophe Devedjian ◽  
Monica George ◽  
Alba Casellas ◽  
Anna Pujol ◽  
Joana Visa ◽  
...  

1997 ◽  
Vol 107 (3) ◽  
pp. 193-203 ◽  
Author(s):  
Leo T. M. Van der Ven ◽  
Paul J. M. Roholl ◽  
Maria G. Reijnen-Gresnigt ◽  
Ruud J. Bloemen ◽  
Sylvia C. van Buul-Offers

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