scholarly journals Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury

2013 ◽  
Vol 113 (9) ◽  
pp. 2275-2283 ◽  
Author(s):  
Melissa Lynn Erickson ◽  
Terence E. Ryan ◽  
Hui-Ju Young ◽  
Kevin K. McCully
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Near Infrared ◽  
Oxidative Capacity ◽  
Muscle Oxidative Capacity ◽  
Cord Injury

scholarly journals Near-infrared light-triggered NO release for spinal cord injury repair

2020 ◽  
Vol 6 (39) ◽  
pp. eabc3513
Author(s):  
Yaqin Jiang ◽  
Pengfei Fu ◽  
Yanyan Liu ◽  
Chaochao Wang ◽  
Peiran Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Near Infrared ◽  
Nerve Repair ◽  
Infrared Light ◽  
Zeolitic Imidazolate Framework ◽  
No Donor ◽  
Cord Injury ◽  
No Release ◽  
Blood Spinal Cord Barrier

Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a single function. Here, we suggest a “pleiotropic messenger” strategy based on near-infrared (NIR)–triggered on-demand NO release at the lesion area for traumatic SCI recovery via the concurrent neuroregeneration and neuroprotection processing. This NO delivery system was constructed as upconversion nanoparticle (UCNP) core coated by zeolitic imidazolate framework–8 (ZIF-8) with NO donor (CysNO). This combined strategy substantial promotes the repair of SCI in vertebrates, ascribable to the pleiotropic effects of NO including the suppression of gliosis and inflammation, the promotion of neuroregeneration, and the protection of neurons from apoptosis, which opens intriguing perspectives not only in nerve repair but also in neurological research and tissue engineering.

scholarly journals Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury

2018 ◽  
Vol 223 (3) ◽  
pp. e13051 ◽  
Author(s):  
L. S. Lundell ◽  
M. Savikj ◽  
E. Kostovski ◽  
P. O. Iversen ◽  
J. R. Zierath ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Protein Translation ◽  
Skeletal Muscle Atrophy ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document