Effect of calmodulin on Ca 2+ -induced Ca 2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3

1998 ◽  
Vol 437 (1) ◽  
pp. 43-48 ◽  
Author(s):  
T. Ikemoto ◽  
H. Takeshima ◽  
M. Iino ◽  
M. Endo
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3

scholarly journals Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

2019 ◽  
Vol 170 (2) ◽  
pp. 509-524
Author(s):  
Kim M Truong ◽  
Gennady Cherednichenko ◽  
Isaac N Pessah
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Membrane Vesicles ◽  
Receptor Type ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Voltage Gated Sodium Channels ◽  
Muscle Health ◽  
Living Organisms

Abstract Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-gated sodium channels, it mediates toxicity in mammals by acting as an endocrine disruptor (ED). Numerous studies demonstrate DDT/DDE to be EDs, but studies examining muscle-specific effects mediated by nonhormonal receptors in mammals are lacking. Therefore, we investigated whether o,p′-DDT, p,p′-DDT, o,p′-DDE, and p,p′-DDE (DDx, collectively) alter the function of ryanodine receptor type 1 (RyR1), a protein critical for skeletal muscle excitation-contraction coupling and muscle health. DDx (0.01–10 µM) elicited concentration-dependent increases in [3H]ryanodine ([3H]Ry) binding to RyR1 with o,p′-DDE showing highest potency and efficacy. DDx also showed sex differences in [3H]Ry-binding efficacy toward RyR1, where [3H]Ry-binding in female muscle preparations was greater than male counterparts. Measurements of Ca2+ transport across sarcoplasmic reticulum (SR) membrane vesicles further confirmed DDx can selectively engage with RyR1 to cause Ca2+ efflux from SR stores. DDx also disrupts RyR1-signaling in HEK293T cells stably expressing RyR1 (HEK-RyR1). Pretreatment with DDx (0.1–10 µM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner. o,p′-DDE (24 h; 1 µM) significantly increased Ca2+-transient amplitude from electrically stimulated mouse myotubes compared with control and displayed abnormal fatigability. In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health.

scholarly journals Generation and Characterization of Mutant Mice Lacking Ryanodine Receptor Type 3

1996 ◽  
Vol 271 (33) ◽  
pp. 19649-19652 ◽  
Author(s):  
Hiroshi Takeshima ◽  
Takaaki Ikemoto ◽  
Miyuki Nishi ◽  
Nobuyoshi Nishiyama ◽  
Misa Shimuta ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3

scholarly journals Facilitation of NMDAR-Independent LTP and Spatial Learning in Mutant Mice Lacking Ryanodine Receptor Type 3

Neuron ◽  
1999 ◽  
Vol 24 (3) ◽  
pp. 701-713 ◽  
Author(s):  
Akira Futatsugi ◽  
Kunio Kato ◽  
Hiroo Ogura ◽  
Sheng-Tian Li ◽  
Eiichiro Nagata ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Spatial Learning ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3

Treatment of Normal Skeletal Muscle with FK506 or Rapamycin Results in Halothane-induced Muscle Contracture

1998 ◽  
Vol 89 (3) ◽  
pp. 693-698. ◽  
Author(s):  
Richard L. Brooksbank ◽  
Margaret E. Badenhorts ◽  
Hyam Isaacs ◽  
Nerina Savage
Keyword(s):  
Carbon Dioxide ◽  
Skeletal Muscle ◽  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Type ◽  
Muscle Strip ◽  
Healthy Human ◽  
Healthy Persons

Background FKBP12 is a protein that is closely associated with the ryanodine receptor type 1 of skeletal muscle and modulates Ca2+ release by the channel. The immunosuppressants FK506 and rapamycin both bind to FKBP12 and in turn dissociate the protein from the ryanodine receptor. By treating healthy human skeletal muscle strips with FK506 or rapamycin and then subjecting the strips to the caffeine-halothane contracture test, this study determined that FK506 and rapamycin alter the sensitivity of the muscle strip to halothane, caffeine, or both. Methods Skeletal muscle strips from 10 healthy persons were incubated in Krebs medium equilibrated with a 95% oxygen and 5% carbon dioxide mixture, which contained either 12 microM FK506 (n = 8) or 12 microM rapamycin (n = 6), for 15 min at 37 degrees C. The strips were subjected to the caffeine-halothane contracture test for malignant hyperthermia according to the European Malignant Hyperthermia Group protocol. Results Treatment of normal skeletal muscle strips with FK506 and rapamycin resulted in halothane-induced contractures of 0.44+/-0.16 g and 0.6+/-0.49 g, respectively, at 2% halothane. Conclusions The results obtained show that pre-exposure of healthy skeletal muscle strips to either FK506 or rapamycin is sufficient to give rise to halothane-induced contractures. This is most likely caused by destabilization of Ca2+ release by the ryanodine receptor as a result of the dissociation of FKBP12. This finding suggests that a mutation in FKBP12 or changes in its capacity to bind to the ryanodine receptor could alter the halothane sensitivity of the skeletal muscle ryanodine receptor and thereby predispose the person to malignant hyperthermia.

scholarly journals Imperatoxin A Enhances Ca2+ Release in Developing Skeletal Muscle Containing Ryanodine Receptor Type 3

2002 ◽  
Vol 82 (3) ◽  
pp. 1319-1328 ◽  
Author(s):  
Thomas Nabhani ◽  
Xinsheng Zhu ◽  
Ilenia Simeoni ◽  
Vincenzo Sorrentino ◽  
Héctor H. Valdivia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Receptor Type ◽  
Type 3

scholarly journals Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure

2013 ◽  
Vol 32 (9) ◽  
pp. 925-929 ◽  
Author(s):  
Eric Rullman ◽  
Daniel C. Andersson ◽  
Michael Melin ◽  
Steven Reiken ◽  
Donna M. Mancini ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Receptor Type ◽  
Exercise Intolerance

Involvement of Ryanodine Receptor Type 3 in Dopamine Release from the Striatum: Evidence from Mutant Mice Lacking This Receptor

1999 ◽  
Vol 266 (2) ◽  
pp. 588-592 ◽  
Author(s):  
Keiko Wan ◽  
Takahiro Moriya ◽  
Masashi Akiyama ◽  
Hiroshi Takeshima ◽  
Shigenobu Shibata
Keyword(s):  
Ryanodine Receptor ◽  
Dopamine Release ◽  
Mutant Mice ◽  
Receptor Type ◽  
Type 3
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