In stage II/III lymph node-positive breast cancer patients less than 55 years of age, keratin 8 expression in lymph node metastases but not in the primary tumour is an indicator of better survival

2015 ◽  
Vol 466 (5) ◽  
pp. 571-580 ◽  
Author(s):  
Serena Bonin ◽  
Danae Pracella ◽  
Renzo Barbazza ◽  
Sandro Sulfaro ◽  
Giorgio Stanta
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Primary Tumour ◽  
Stage Ii ◽  
Breast Cancer Patients ◽  
Node Metastases ◽  
Lymph Node Positive ◽  
Positive Breast Cancer

Comparison of two models for predicting non-sentinel lymph node metastases in sentinel lymph node-positive breast cancer patients

2011 ◽  
Vol 63 (3) ◽  
pp. 163-170 ◽  
Author(s):  
Giovanni D’Eredita’ ◽  
Vito Leopoldo Troilo ◽  
Fernando Fischetti ◽  
Giuseppe Rubini ◽  
Tommaso Berardi
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Breast Cancer Patients ◽  
Node Positive ◽  
Node Metastases ◽  
Lymph Node Positive ◽  
Positive Breast Cancer

ALDH1-positive cells in primary tumor and axillary lymph node metastases after chemotherapy as a prognostic factor in breast cancer patients.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1097-1097
Author(s):  
Masahiro Sakakibara ◽  
Takeshi Nagashima ◽  
Takafumi Sangai ◽  
Hiroshi Fujimoto ◽  
Tiberu-Hiroshi Suzuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Metastatic Lesions ◽  
Node Metastases ◽  
Positive Breast Cancer

1097 Background: The cancer stem cell theory that was established for hematopoietic neoplasms has significantly changed the concept of cancer therapy. Aldehyde dehydrogenase 1 (ALDH1)-positive cells show stem-like or progenitor ability, and have been considered as a clinically important diagnostic and therapeutic target in breast cancer patients. However, responsiveness of ALDH1-positive cells to chemotherapy in primary and metastatic lesions remains unclear, along with relationships to prognosis in patients with breast cancer. This study evaluated responsiveness to chemotherapy in the ALDH1-positive cells for primary and metastatic lesions and relationships to prognosis in patients with node-positive breast cancer. Methods: We evaluated 115 breast cancer patients with cytologically confirmed lymph node metastases who had undergone surgery after neoadjuvant chemotherapy (NAC). Using ALDH1 immunohistochemistry of core needle biopsy for the primary tumor and cytology samples for axillary lymph nodes before NAC and pathological samples of each after NAC, we evaluated the clinical significance of ALDH1-positive cell status in primary and metastatic lesions before and after NAC. Results: Presence of ALDH1-positive cancer cells, not ALDH1-negative cancer cells, in primary and metastatic lesions after NAC was associated with worse prognosis. In multivariate analysis, only ALDH1-positive cells in metastatic lesions after NAC correlated with overall survival. Responsiveness of ALDH1-positive cells to chemotherapy differed between primary and metastatic lesions, and ALDH1-positive cells in metastatic lesions after NAC might clinically precede those in the primary lesion. Conclusions: Responsiveness of the ALDH1-positive cells to chemotherapy in primary and metastatic lesions, and the prognostic significance, were clarified in breast cancer patients. ALDH1-positive status might offer a surrogate marker as a new concept in patients with node-positive breast cancer.

Predictors for extensive nodal involvement in breast cancer patients with axillary lymph node metastases

The Breast ◽  
2016 ◽  
Vol 27 ◽  
pp. 175-181 ◽  
Author(s):  
N.C. Verheuvel ◽  
H.W.A. Ooms ◽  
V.C.G. Tjan-Heijnen ◽  
R.M.H. Roumen ◽  
A.C. Voogd
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Nodal Involvement ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases
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