The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus

2016 ◽  
Vol 468 (4) ◽  
pp. 483-492 ◽  
Author(s):  
Ergin Kilic ◽  
Pierre Tennstedt ◽  
Anica Högner ◽  
Patrick Lebok ◽  
Guido Sauter ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Zinc Finger ◽  
Squamous Cell ◽  
Adenocarcinoma Of The Esophagus ◽  
Zinc Finger Transcription Factor ◽  
Human Cancers

scholarly journals Identification of E2F transcription factor 7 as a novel potential biomarker for oral squamous cell carcinoma

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Ping Zhou ◽  
Lei Xiao ◽  
Xiaonan Xu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Loss Function ◽  
High Expression ◽  
E2f Transcription Factor ◽  
Gain And Loss

Abstract Background As a tumor-accelerating transcriptional factor, E2F transcription factor 7 (E2F7) was up-regulated in many forms of cancers. Nevertheless, little has been reported about the impacts of E2F7 on oral squamous cell carcinoma (OSCC). Here, we aimed to probe whether E2F7 had influences on OSCC and its potential mechanism. Methods The expression of E2F7 in OSCC tissues was analyzed using the data acquired from TCGA and ONCOMINE databases. E2F7 prognostic value in OSCC patients was analyzed utilizing TCGA database. The expression of E2F7 in OSCC cell lines was detected by qRT-PCR. Gain-and loss-function of E2F7 assays in TCA-83 and CAL27 cells were performed respectively to inquire the function of E2F7. Western blotting was applied to test the alternations of EMT-related markers. Results In OSCC tissues, E2F7 was highly expressed. Besides, high expression of E2F7 predicted worse prognosis in OSCC patients. Moreover, E2F7 was over-expressed in TCA-83, HSC-4 and CAL27 (all OSCC cell lines) cells relative to that in HNOK (a normal cell line) cells. Gain-and loss-function assays displayed that deficiency of E2F7 suppresses CAL27 cell growth, migration, invasion and E2F7 high-expression resulted in inverse outcomes in TCA-83 cells. Finally, we found that silencing of E2F7 facilitated E-cadherin protein expression level and reduced N-cadherin, Vimentin and Snail protein levels in CAL27 cells, whilst E2F7 high-expression exhibited the opposite effects in TCA-83 cells. Conclusions These outcomes indicated that E2F7 performs a carcinogenic role in OSCC, which provides a theoretical basis for the therapeutic strategies of OSCC.

Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma

2014 ◽  
Vol 20 (2) ◽  
pp. 298-307 ◽  
Author(s):  
Yoshiaki Kamikawa ◽  
Yuji Kanmura ◽  
Tomofumi Hamada ◽  
Norishige Yamada ◽  
Muzafar A. Macha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Muc4 Expression

scholarly journals Hypermethylation of a Cluster of Krüppel-Type Zinc Finger Protein Genes on Chromosome 19q13 in Oropharyngeal Squamous Cell Carcinoma

2011 ◽  
Vol 178 (5) ◽  
pp. 1965-1974 ◽  
Author(s):  
Roberto A. Lleras ◽  
Leslie R. Adrien ◽  
Richard V. Smith ◽  
Benjamin Brown ◽  
Naheed Jivraj ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Zinc Finger ◽  
Squamous Cell ◽  
Zinc Finger Protein ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Finger Protein ◽  
Chromosome 19Q13

The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells

2013 ◽  
Vol 430 (3) ◽  
pp. 889-894 ◽  
Author(s):  
Kenichi Kume ◽  
Misako Haraguchi ◽  
Hiroshi Hijioka ◽  
Takayuki Ishida ◽  
Akihiko Miyawaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
E Cadherin

scholarly journals Keratinization of Lung Squamous Cell Carcinoma Is Associated with Poor Clinical Outcome

2017 ◽  
Vol 80 (2) ◽  
pp. 179 ◽  
Author(s):  
Hye Jung Park ◽  
Yoon-Jin Cha ◽  
Seong Han Kim ◽  
Arum Kim ◽  
Eun Young Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Squamous Cell Carcinoma ◽  
Poor Clinical Outcome

Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages

2011 ◽  
Vol 412 (15-16) ◽  
pp. 1357-1365 ◽  
Author(s):  
Yu-Jen Jou ◽  
Chia-Der Lin ◽  
Chih-Ho Lai ◽  
Chih-Hsin Tang ◽  
Su-Hua Huang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Zinc Finger ◽  
Squamous Cell ◽  
Zinc Finger Protein ◽  
Early Stages ◽  
Finger Protein
Sign in / Sign up

Export Citation Format

Share Document