Cellular dissociation: a missing item in the pathology report and histologic grading of oral tongue cancer?

2022 ◽  
Author(s):  
Alhadi Almangush ◽  
Antti A. Mäkitie ◽  
Ilmo Leivo
Keyword(s):  
Tongue Cancer ◽  
Pathology Report ◽  
Oral Tongue ◽  
Histologic Grading ◽  
Oral Tongue Cancer ◽  
Missing Item

scholarly journals Improving Risk Stratification of Early Oral Tongue Cancer with TNM-Immune (TNM-I) Staging System

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3235
Author(s):  
Alhadi Almangush ◽  
Ibrahim O. Bello ◽  
Ilkka Heikkinen ◽  
Jaana Hagström ◽  
Caj Haglund ◽  
...  
Keyword(s):  
Overall Survival ◽  
Tongue Cancer ◽  
Early Stage ◽  
Disease Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Staging System ◽  
Oral Tongue ◽  
Oral Tongue Cancer ◽  
Important Player ◽  
Infiltrating Lymphocytes

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.

scholarly journals A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

2021 ◽  
Author(s):  
Marta Tagliabue ◽  
Pietro Belloni ◽  
Rita De Berardinis ◽  
Sara Gandini ◽  
Francesco Chu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tongue Cancer ◽  
Meta Analysis ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Oral Tongue Cancer

Rising incidence of oral tongue cancer among white men and women in the United States, 1973–2012

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 146-152 ◽  
Author(s):  
Joseph E. Tota ◽  
William F. Anderson ◽  
Charles Coffey ◽  
Joseph Califano ◽  
Wendy Cozen ◽  
...  
Keyword(s):  
United States ◽  
Tongue Cancer ◽  
White Men ◽  
The United States ◽  
Oral Tongue ◽  
Men And Women ◽  
Oral Tongue Cancer ◽  
Rising Incidence

NOVEL ADVANCES IN STAGING AND GRADING OF EARLY ORAL TONGUE CANCER: A MULTICENTER STUDY

2021 ◽  
Vol 132 (1) ◽  
pp. e4-e5
Author(s):  
A Almangush ◽  
RD Coletta ◽  
AA Mäkitie ◽  
T Salo ◽  
I Leivo
Keyword(s):  
Multicenter Study ◽  
Tongue Cancer ◽  
Oral Tongue ◽  
Oral Tongue Cancer

PO-0809: Lymph flow guided radiotherapy for oral tongue cancer: histological verification of the concept

2020 ◽  
Vol 152 ◽  
pp. S439
Author(s):  
S. Novikov ◽  
P. Krzhivitckiy ◽  
Z. Radgabova ◽  
S. Kanaev ◽  
M. Kotov ◽  
...  
Keyword(s):  
Tongue Cancer ◽  
Lymph Flow ◽  
Oral Tongue ◽  
Oral Tongue Cancer ◽  
Histological Verification

scholarly journals Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy

2010 ◽  
Vol 5 (1) ◽  
pp. 43 ◽  
Author(s):  
Su Jung Shim ◽  
Jihye Cha ◽  
Woong Sub Koom ◽  
Gwi Eon Kim ◽  
Chang Geol Lee ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Clinical Outcomes ◽  
Tongue Cancer ◽  
Postoperative Radiotherapy ◽  
Oral Tongue ◽  
Oral Tongue Cancer

R004: Expression of Apoptosis-Relate Proteins in Oral Tongue Cancer

2006 ◽  
Vol 135 (2_suppl) ◽  
pp. P105-P106
Author(s):  
Hyung-Cheol Jo ◽  
Chang-Su Park ◽  
Mu-Hyun Kans ◽  
Min-Hee Jans ◽  
Hi-Boong Kawk ◽  
...  
Keyword(s):  
Tongue Cancer ◽  
Oral Tongue ◽  
Oral Tongue Cancer

Treatment of stage I and II oral tongue cancer

Head & Neck ◽  
1993 ◽  
Vol 15 (4) ◽  
pp. 308-312 ◽  
Author(s):  
Daniel D. Lydiatt ◽  
K. Thomas Robbins ◽  
Robert M. Byers ◽  
Patricia F. Wolf
Keyword(s):  
Tongue Cancer ◽  
Stage I ◽  
Oral Tongue ◽  
Oral Tongue Cancer

scholarly journals Early onset oral tongue cancer in the United States: A literature review

Oral Oncology ◽  
2018 ◽  
Vol 87 ◽  
pp. 1-7 ◽  
Author(s):  
Benjamin R. Campbell ◽  
James L. Netterville ◽  
Robert J. Sinard ◽  
Kyle Mannion ◽  
Sarah L. Rohde ◽  
...  
Keyword(s):  
United States ◽  
Literature Review ◽  
Early Onset ◽  
Tongue Cancer ◽  
The United States ◽  
Oral Tongue ◽  
Oral Tongue Cancer
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