Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses

Abstract We present high-density EEG datasets of auditory steady-state responses (ASSRs) recorded from the cortex of freely moving mice with or without optogenetic stimulation of basal forebrain parvalbumin (BF-PV) neurons, known as a subcortical hub circuit for the global workspace. The dataset of ASSRs without BF-PV stimulation (dataset 1) contains raw 36-channel EEG epochs of ASSRs elicited by 10, 20, 30, 40, and 50 Hz click trains and time stamps of stimulations. The dataset of ASSRs with BF-PV stimulation (dataset 2) contains raw 36-channel EEG epochs of 40-Hz ASSRs during BF-PV stimulation with latencies of 0, 6.25, 12.5, and 18.75 ms and time stamps of stimulations. We provide the datasets and step-by-step tutorial analysis scripts written in Python, allowing for descriptions of the event-related potentials, spectrograms, and the topography of power. We complement this experimental dataset with simulation results using a time-dependent perturbation on coupled oscillators. This publicly available dataset will be beneficial to the experimental and computational neuroscientists.

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Estimating Hearing Thresholds in Infants Using Auditory Steady-State Responses

Perspectives on Hearing and Hearing Disorders Research and Diagnostics ◽

10.1044/hhd6.1.9 ◽

2002 ◽

Vol 6 (1) ◽

pp. 9

Author(s):

Craig A. Champlin

Keyword(s):

Steady State ◽

Hearing Thresholds ◽

Steady State Responses ◽

Auditory Steady State Responses ◽

State Responses

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Réhabilitation auditive. Exploration Objective de l'audition. Les ASSR (Auditory Steady-State Responses) au service de l'audioprothèse

Sciences et Technologies pour le Handicap ◽

10.3166/sth.3.173-211 ◽

2009 ◽

Vol 3 (2) ◽

pp. 173-211

Author(s):

Mikael Ménard ◽

Stéphane Gallégo ◽

Hung Thai-Van

Keyword(s):

Steady State ◽

Steady State Responses ◽

Auditory Steady State Responses ◽

State Responses

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Reliable Selection of Auditory Steady-State Responses Parameters under Bone, Insertphone and Speaker Stimulations

Audiology and Speech Research ◽

10.21848/audiol.2005.1.1.44 ◽

2005 ◽

Vol 1 (1) ◽

pp. 44-50

Author(s):

Dong-Geun Han ◽

Dukhwan Lim

Keyword(s):

Steady State ◽

Steady State Responses ◽

Auditory Steady State Responses ◽

State Responses ◽

Selection Of

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Estimating the Audiogram Using Multiple Auditory Steady-State Responses

Journal of the American Academy of Audiology ◽

10.1055/s-0040-1715964 ◽

2002 ◽

Vol 13 (04) ◽

pp. 205-224 ◽

Cited By ~ 30

Author(s):

Andrew Dimitrijevic ◽

Sasha M. John ◽

Patricia Van Roon ◽

David W. Purcell ◽

Julija Adamonis ◽

...

Keyword(s):

Steady State ◽

Correlation Coefficients ◽

Behavioral Threshold ◽

Behavioral Thresholds ◽

Sensorineural Hearing Impairment ◽

Steady State Responses ◽

Auditory Steady State Responses ◽

Tonal Stimuli ◽

Conductive Hearing ◽

State Responses

Multiple auditory steady-state responses were evoked by eight tonal stimuli (four per ear), with each stimulus simultaneously modulated in both amplitude and frequency. The modulation frequencies varied from 80 to 95 Hz and the carrier frequencies were 500, 1000, 2000, and 4000 Hz. For air conduction, the differences between physiologic thresholds for these mixed-modulation (MM) stimuli and behavioral thresholds for pure tones in 31 adult subjects with a sensorineural hearing impairment and 14 adult subjects with normal hearing were 14 ± 11, 5 ± 9, 5 ± 9, and 9 ± 10 dB (correlation coefficients .85, .94, .95, and .95) for the 500-, 1000-, 2000-, and 4000-Hz carrier frequencies, respectively. Similar results were obtained in subjects with simulated conductive hearing losses. Responses to stimuli presented through a forehead bone conductor showed physiologic-behavioral threshold differences of 22 ± 8, 14 ± 5, 5 ± 8, and 5 ± 10 dB for the 500-, 1000-, 2000-, and 4000-Hz carrier frequencies, respectively. These responses were attenuated by white noise presented concurrently through the bone conductor.

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