Speech rate association with cerebellar white-matter diffusivity in adults with persistent developmental stuttering

2021 ◽  
Vol 226 (3) ◽  
pp. 801-816
Author(s):  
Sivan Jossinger ◽  
Vered Kronfeld-Duenias ◽  
Avital Zislis ◽  
Ofer Amir ◽  
Michal Ben-Shachar
2018 ◽  
Vol 55 ◽  
pp. 68-83 ◽  
Author(s):  
Vered Kronfeld-Duenias ◽  
Oren Civier ◽  
Ofer Amir ◽  
Ruth Ezrati-Vinacour ◽  
Michal Ben-Shachar

Author(s):  
Sivan Jossinger ◽  
Anastasia Sares ◽  
Avital Zislis ◽  
Dana Suri-Barot ◽  
Vincent Gracco ◽  
...  

Author(s):  
Nicole E Neef ◽  
Annika Primaßin ◽  
Alexander Wolff von Gudenberg ◽  
Peter Dechent ◽  
Heiner Christian Riedel ◽  
...  

Abstract Recent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional connectivity of the dorsal laryngeal motor cortical network. Currently, it is unknown whether the underlying structural network organization of these two laryngeal representations is distinct or differently shaped by stuttering intervention. Using probabilistic diffusion tractography in 22 individuals who stutter and participated in a fluency shaping intervention, in 18 individuals who stutter and did not participate in the intervention, and in 28 control participants, we here compare structural networks of the dorsal laryngeal motor cortex and the ventral laryngeal motor cortex and test intervention-related white matter changes. We show (i) that all participants have weaker ventral laryngeal motor cortex connections compared to the dorsal laryngeal motor cortex network, regardless of speech fluency, (ii) connections of the ventral laryngeal motor cortex were stronger in fluent speakers, (iii) the connectivity profile of the ventral laryngeal motor cortex predicted stuttering severity, (iv) but the ventral laryngeal motor cortex network is resistant to a fluency shaping intervention. Our findings substantiate a weaker structural organization of the ventral laryngeal motor cortical network in developmental stuttering and imply that assisted recovery supports neural compensation rather than normalization. Moreover, the resulting dissociation provides evidence for functionally segregated roles of the ventral laryngeal motor cortical and dorsal laryngeal motor cortical networks.


Revista CEFAC ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 281-290 ◽  
Author(s):  
Paula Bianca Meireles de Moura Buzzeti ◽  
Cristiane Moço Canhetti de Oliveira

ABSTRACT Objective: to describe the immediate effects of delayed auditory feedback on stuttering-like disfluencies in people who stutter. Methods: a cross-sectional and experimental study. The effect of delayed auditory feedback was analyzed in thirty individuals, from eight to 46 years old, diagnosed with persistent developmental stuttering. Participants should present at least 3% of stuttering-like disfluencies and mild stuttering according to the Stuttering Severity Instrument. The following procedures were used: audiological evaluation, fluency evaluation in two listening situations - with Non-altered and delayed auditory feedback - and the Stuttering Severity Instrument. The Fono Tools software was used to cause the delay effect. Data analysis was performed using pertinent statistical tests. Results: there was no decrease in most stuttering-like disfluencies. There was a statistically significant reduction in word repetition and flow of syllables per minute. Conclusion: the delay in auditory feedback caused, as an immediate effect, the reduction of word repetition and speech rate, in syllables per minute.


2020 ◽  
Author(s):  
Nicole E. Neef ◽  
Annika Primaßin ◽  
Alexander Wolff von Gudenberg ◽  
Peter Dechent ◽  
Heiner Christian Riedel ◽  
...  

AbstractRecent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional connectivity of the dorsal laryngeal motor cortical network. Currently, it is unknown whether the underlying structural network organization of these two laryngeal representations is distinct or differently shaped by stuttering intervention. Using probabilistic diffusion tractography in 22 individuals who stutter and participated in a fluency shaping intervention, in 18 individuals who stutter and did not participate in the intervention, and in 28 control participants, we here compare structural networks of the dorsal laryngeal motor cortex and the ventral laryngeal motor cortex and test intervention-related white matter changes. We show (i) that all participants have weaker ventral laryngeal motor cortex connections compared to the dorsal laryngeal motor cortex network, regardless of speech fluency, (ii) connections of the ventral laryngeal motor cortex were stronger in fluent speakers, (iii) the connectivity profile of the ventral laryngeal motor cortex predicted stuttering severity, (iv) but the ventral laryngeal motor cortex network is resistant to a fluency shaping intervention. Our findings substantiate a weaker structural organization of the ventral laryngeal motor cortical network in developmental stuttering and imply that assisted recovery supports neural compensation rather than normalization. Moreover, the resulting dissociation provides evidence for functionally segregated roles of the ventral laryngeal motor cortical and dorsal laryngeal motor cortical networks.


Author(s):  
Frederik Grosse ◽  
Stefan Mark Rueckriegel ◽  
Ulrich-Wilhelm Thomale ◽  
Pablo Hernáiz Driever

Abstract Purpose Diaschisis of cerebrocerebellar loops contributes to cognitive and motor deficits in pediatric cerebellar brain tumor survivors. We used a cerebellar white matter atlas and hypothesized that lesion symptom mapping may reveal the critical lesions of cerebellar tracts. Methods We examined 31 long-term survivors of pediatric posterior fossa tumors (13 pilocytic astrocytoma, 18 medulloblastoma). Patients underwent neuronal imaging, examination for ataxia, fine motor and cognitive function, planning abilities, and executive function. Individual consolidated cerebellar lesions were drawn manually onto patients’ individual MRI and normalized into Montreal Neurologic Institute (MNI) space for further analysis with voxel-based lesion symptom mapping. Results Lesion symptom mapping linked deficits of motor function to the superior cerebellar peduncle (SCP), deep cerebellar nuclei (interposed nucleus (IN), fastigial nucleus (FN), ventromedial dentate nucleus (DN)), and inferior vermis (VIIIa, VIIIb, IX, X). Statistical maps of deficits of intelligence and executive function mapped with minor variations to the same cerebellar structures. Conclusion We identified lesions to the SCP next to deep cerebellar nuclei as critical for limiting both motor and cognitive function in pediatric cerebellar tumor survivors. Future strategies safeguarding motor and cognitive function will have to identify patients preoperatively at risk for damage to these critical structures and adapt multimodal therapeutic options accordingly.


Cortex ◽  
2016 ◽  
Vol 81 ◽  
pp. 79-92 ◽  
Author(s):  
Vered Kronfeld-Duenias ◽  
Ofer Amir ◽  
Ruth Ezrati-Vinacour ◽  
Oren Civier ◽  
Michal Ben-Shachar

Author(s):  
Cara M. Singer ◽  
Sango Otieno ◽  
Soo-Eun Chang ◽  
Robin M. Jones

Purpose: The purpose of this study was to explore how well a cumulative risk approach, based on empirically supported predictive factors, predicts whether a young child who stutters is likely to develop persistent developmental stuttering. In a cumulative risk approach, the number of predictive factors indicating a child is at risk to develop persistent stuttering is evaluated, and a greater number of indicators of risk are hypothesized to confer greater risk of persistent stuttering. Method: We combined extant data on 3- to 5-year-old children who stutter from two longitudinal studies to identify cutoff values for continuous predictive factors (e.g., speech and language skills, age at onset, time since onset, stuttering frequency) and, in combination with binary predictors (e.g., sex, family history of stuttering), used all-subsets regression and receiver operating characteristic curves to compare the predictive validity of different combinations of 10 risk factors. The optimal combination of predictive factors and the odds of a child developing persistent stuttering based on an increasing number of factors were calculated. Results: Based on 67 children who stutter (i.e., 44 persisting and 23 recovered) with relatively strong speech-language skills, the predictive factor model that yielded the best predictive validity was based on time since onset (≥ 19 months), speech sound skills (≤ 115 standard score), expressive language skills (≤ 106 standard score), and stuttering severity (≥ 17 Stuttering Severity Instrument total score). When the presence of at least two predictive factors was used to confer elevated risk to develop persistent stuttering, the model yielded 93% sensitivity and 65% specificity. As a child presented with a greater number of these four risk factors, the odds for persistent stuttering increased. Conclusions: Findings support the use of a cumulative risk approach and the predictive utility of assessing multiple domains when evaluating a child's risk of developing persistent stuttering. Clinical implications and future directions are discussed.


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