Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development

2018 ◽  
Vol 208 (1) ◽  
pp. 3-24 ◽  
Author(s):  
Volker Lohmann
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Basic Research ◽  
The Road ◽  
Culture Models ◽  
Therapy Development ◽  
Cell Culture Models

scholarly journals Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models

Hepatology ◽  
2010 ◽  
Vol 53 (1) ◽  
pp. 32-41 ◽  
Author(s):  
Emmanuel Thomas ◽  
Jordan J. Feld ◽  
Qisheng Li ◽  
Zongyi Hu ◽  
Michael W. Fried ◽  
...  
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Gene Induction ◽  
Culture Models ◽  
Cell Culture Models

Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C

Lab Animal ◽  
2005 ◽  
Vol 34 (2) ◽  
pp. 39-47 ◽  
Author(s):  
Chandan Guha ◽  
Sung-W Lee ◽  
Namita Roy Chowdhury ◽  
Jayanta Roy Chowdhury
Keyword(s):  
Cell Culture ◽  
Hepatitis C ◽  
Animal Models ◽  
Viral Hepatitis ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 211
Author(s):  
Chui-Wa So ◽  
Glenn Randall
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Three Dimensional ◽  
Hcv Infection ◽  
Culture Systems ◽  
Cell Culture Systems ◽  
Culture Models ◽  
Dimensional Cell

Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection.

Investigations into the receptor requirements of Hepatitis C Virus (HCV) pseudoparticles and cell culture grown virions

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
T von Hahn ◽  
M Flint ◽  
BD Lindenbach ◽  
A Boullier ◽  
O Quehenberger ◽  
...  
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C

Hepatitis C Virus Infection: A Brief Review

JMS SKIMS ◽  
2020 ◽  
Vol 23 (1) ◽  
pp. 3-15
Author(s):  
Saleem Kamili ◽  
Hisham Qadri
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Basic Research ◽  
World Health ◽  
Hepatitis C Virus Infection ◽  
Poor Countries ◽  
Diagnostic Assays ◽  
Antiviral Therapies ◽  
Highly Sensitive ◽  
Resource Poor

Hepatitis C, caused by hepatitis C virus (HCV) was originally described as parenterally transmitted non-A non-B hepatitis. Since its discovery in 1989, the field of HCV research has become a shining example of successful translation of basic research wherein in a short of span of just 30 years the virus was discovered, highly sensitive and specific diagnostic assays were developed, epidemiology and clinical characteristics of the disease were well defined and now with the availability of highly efficacious antiviral therapies many countries are already on their way to achieving World Health Organization’s (WHO) elimination targets of hepatitis C by 2030.  However, much work needs to be done to eliminate hepatitis C especially in resource poor countries. Most recent data show an estimated 71 million people are currently infected with HCV worldwide and approximately 400,000 people die each year from causes related to HCV. Of these estimates, more than 13 million HCV infected persons are in India and Pakistan (Figure 1). Despite the availability of a cure for hepatitis C, only 20% of those infected patients have been diagnosed (1). In order to achieve the WHO targets of hepatitis C elimination, concerted efforts will have to made to make affordable and reliable diagnostics available worldwide.

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