Association between age and synchronous liver metastasis in female colorectal cancer patients

2010 ◽  
Vol 137 (6) ◽  
pp. 959-964
Author(s):  
Lin Wang ◽  
Lei Wang ◽  
Wenbin Yu ◽  
Guangyong Zhang ◽  
Lifeng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

The prognostic significance of resection of primary tumor in gastric and colorectal cancer patients with synchronous liver metastasis

1988 ◽  
Vol 18 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Kazuaki Okuyama ◽  
Shoichi Onoda ◽  
Noriyuki Tohnosu ◽  
Yoshikazu Yamamoto ◽  
Yoshio Koide ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Prognostic Significance ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

Association between age and synchronous liver metastasis in colorectal cancer patients

2019 ◽  
Vol 45 (2) ◽  
pp. e41
Author(s):  
A. Diamantis ◽  
K. Perivoliotis ◽  
G. Christodoulidis ◽  
D. Vasdeki ◽  
E. Bompou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Clinical study of the prognostic factors in colorectal cancer patients with synchronous liver metastasis

2012 ◽  
Vol 124 (1) ◽  
pp. 47-51
Author(s):  
Hideaki Miyasou ◽  
Kazuhide Iwakawa ◽  
Masaru Inagaki ◽  
Yuuji Kimura ◽  
Manabu Nishie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Clinical Study ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Preoperative chemotherapy in colorectal cancer patients with synchronous liver metastasis

2020 ◽  
Author(s):  
Nobuki Ichikawa ◽  
Toshiya Kamiyama ◽  
Hideki Yokoo ◽  
Shigenori Homma ◽  
Yoshiaki Maeda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Preoperative Chemotherapy ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2418
Author(s):  
Xuezhen Zeng ◽  
Simon E. Ward ◽  
Jingying Zhou ◽  
Alfred S. L. Cheng
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
High Recurrence Rate ◽  
Immune Microenvironment ◽  
Liver Sinusoidal Endothelial Cells ◽  
Premetastatic Niche ◽  
Cancer Pathogenesis ◽  
Colorectal Cancer Patients ◽  
The Impact

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum. Beyond the liver-colon anatomic relationship, emerging evidence highlights the impact of liver immune microenvironment on colorectal liver metastasis. Prior to cancer cell dissemination, hepatocytes secrete multiple factors to recruit or activate immune cells and stromal cells in the liver to form a favorable premetastatic niche. The liver-resident cells including Kupffer cells, hepatic stellate cells, and liver-sinusoidal endothelial cells are co-opted by the recruited cells, such as myeloid-derived suppressor cells and tumor-associated macrophages, to establish an immunosuppressive liver microenvironment suitable for tumor cell colonization and outgrowth. Current treatments including radical surgery, systemic therapy, and localized therapy have only achieved good clinical outcomes in a minority of colorectal cancer patients with liver metastasis, which is further hampered by high recurrence rate. Better understanding of the mechanisms governing the metastasis-prone liver immune microenvironment should open new immuno-oncology avenues for liver metastasis intervention.

scholarly journals CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer

2020 ◽  
Author(s):  
Junwei Tang ◽  
Yifei Feng ◽  
Yuanjian Huang ◽  
Ziwei Xu ◽  
Dongsheng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Liver Metastasis ◽  
Hepatic Metastasis ◽  
Vascular Invasion ◽  
Synchronous Liver Metastasis ◽  
Node Negative ◽  
Common Cancer ◽  
Tumor Tissues ◽  
Colorectal Cancer Patients

Abstract Background Colorectal cancer (CRC) is the fourth most common cancer in men and the third most common cancer in women worldwide. The incidence and mortality of CRC was increasing rapidly in China. Lymph node-negative colorectal cancer patients with synchronous liver metastasis (LNLM1) was defined as “skip” lymph vascular invasion on hepatic metastasis, who presenting poor prognosis. We aiming to investigate the potential mechanism for the “skip” lymph vascular invasion on hepatic metastasis in colorectal cancer. Methods The microarray was applied for screening the transcription landscape of circRNA in lymph node negative CRC patients with synchronous liver metastasis (LNLM1) or without liver metastasis (LNLM0). The gain- and loss-of-function experiments was conducted in CRC cell lines and animal models. The RNA pull-down, RNA immunoprecipitation n was further employed in exploring the detailed mechanism of circRNA and associated target genes. Results We identified the aberrant increased circRNA circ_0124554 (also entitled as circ-LNLM) in tumor tissues of LNLM1 patients comparing with either the tumor tissues of LNLM0 or adjacent tissues of LNLM1. Circ-LNLM1 expression was highly corrected with liver metastasis and vascular invasion. Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. The phosphorylation of AKT (T308/S473) was activated due to the blocked ubiquitination site of Lys in 0-52aa peptide of circ-LNLM. Endogenous plasma expression of circ-LNLM induced poor prognosis of LNLM1 and could distinguish LNLM1 patients from LNLM0. Conclusions The circ-LNLM blocked the ubiquitination of AKT could promote the early metastasis especially for the lymph node-negative colorectal cancer patients with synchronous liver metastasis. The circ-LNLM might be prognosis and diagnosis biomarker for LNLM1 patients.

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