The prognostic significance of resection of primary tumor in gastric and colorectal cancer patients with synchronous liver metastasis

1988 ◽  
Vol 18 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Kazuaki Okuyama ◽  
Shoichi Onoda ◽  
Noriyuki Tohnosu ◽  
Yoshikazu Yamamoto ◽  
Yoshio Koide ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Prognostic Significance ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

Association between age and synchronous liver metastasis in female colorectal cancer patients

2010 ◽  
Vol 137 (6) ◽  
pp. 959-964
Author(s):  
Lin Wang ◽  
Lei Wang ◽  
Wenbin Yu ◽  
Guangyong Zhang ◽  
Lifeng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

Association between age and synchronous liver metastasis in colorectal cancer patients

2019 ◽  
Vol 45 (2) ◽  
pp. e41
Author(s):  
A. Diamantis ◽  
K. Perivoliotis ◽  
G. Christodoulidis ◽  
D. Vasdeki ◽  
E. Bompou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Clinical study of the prognostic factors in colorectal cancer patients with synchronous liver metastasis

2012 ◽  
Vol 124 (1) ◽  
pp. 47-51
Author(s):  
Hideaki Miyasou ◽  
Kazuhide Iwakawa ◽  
Masaru Inagaki ◽  
Yuuji Kimura ◽  
Manabu Nishie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Clinical Study ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Preoperative chemotherapy in colorectal cancer patients with synchronous liver metastasis

2020 ◽  
Author(s):  
Nobuki Ichikawa ◽  
Toshiya Kamiyama ◽  
Hideki Yokoo ◽  
Shigenori Homma ◽  
Yoshiaki Maeda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Preoperative Chemotherapy ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2418
Author(s):  
Xuezhen Zeng ◽  
Simon E. Ward ◽  
Jingying Zhou ◽  
Alfred S. L. Cheng
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
High Recurrence Rate ◽  
Immune Microenvironment ◽  
Liver Sinusoidal Endothelial Cells ◽  
Premetastatic Niche ◽  
Cancer Pathogenesis ◽  
Colorectal Cancer Patients ◽  
The Impact

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum. Beyond the liver-colon anatomic relationship, emerging evidence highlights the impact of liver immune microenvironment on colorectal liver metastasis. Prior to cancer cell dissemination, hepatocytes secrete multiple factors to recruit or activate immune cells and stromal cells in the liver to form a favorable premetastatic niche. The liver-resident cells including Kupffer cells, hepatic stellate cells, and liver-sinusoidal endothelial cells are co-opted by the recruited cells, such as myeloid-derived suppressor cells and tumor-associated macrophages, to establish an immunosuppressive liver microenvironment suitable for tumor cell colonization and outgrowth. Current treatments including radical surgery, systemic therapy, and localized therapy have only achieved good clinical outcomes in a minority of colorectal cancer patients with liver metastasis, which is further hampered by high recurrence rate. Better understanding of the mechanisms governing the metastasis-prone liver immune microenvironment should open new immuno-oncology avenues for liver metastasis intervention.

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