Fasciola hepatica: time-dependent disruption of spermatogenesis following in vivo treatment with triclabendazole

2011 ◽  
Vol 109 (4) ◽  
pp. 1035-1043 ◽  
Author(s):  
Emma Toner ◽  
Gerard P. Brennan ◽  
Robert E. B. Hanna ◽  
Hillary W. J. Edgar ◽  
Ian Fairweather
Keyword(s):  
Fasciola Hepatica ◽  
Time Dependent ◽  
In Vivo Treatment

Ultrastructural changes in the tegument and gut of adult Fasciola hepatica following in vivo treatment with artesunate

2015 ◽  
Vol 154 ◽  
pp. 143-154 ◽  
Author(s):  
J.F. O'Neill ◽  
R.C. Johnston ◽  
L. Halferty ◽  
G.P. Brennan ◽  
I. Fairweather
Keyword(s):  
Fasciola Hepatica ◽  
Ultrastructural Changes ◽  
In Vivo Treatment

Early onset of changes to the reproductive system of Fasciola hepatica following in vivo treatment with triclabendazole

2012 ◽  
Vol 184 (2-4) ◽  
pp. 341-347 ◽  
Author(s):  
R.E.B. Hanna ◽  
S. Scarcella ◽  
H. Solana ◽  
S. McConnell ◽  
I. Fairweather
Keyword(s):  
Reproductive System ◽  
Early Onset ◽  
Fasciola Hepatica ◽  
In Vivo Treatment

Time-dependent changes to the tegumental system and gastrodermis of adult Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host

2010 ◽  
Vol 174 (3-4) ◽  
pp. 218-227 ◽  
Author(s):  
E. Toner ◽  
G.P. Brennan ◽  
R.E.B. Hanna ◽  
H.W. Edgar ◽  
I. Fairweather
Keyword(s):  
Fasciola Hepatica ◽  
Time Dependent

The Natural Flavonoid Naringenin Inhibits the Cell Growth of WilmsTumorinChildren by Suppressing TLR4/NF-κB Signaling

2020 ◽  
Vol 20 ◽  
Author(s):  
Hongtao Li ◽  
Peng Chen ◽  
Lei Chen ◽  
Xinning Wang
Keyword(s):  
Cell Growth ◽  
Western Blot ◽  
Wilms Tumor ◽  
Critical Role ◽  
Time Dependent ◽  
Luciferase Assay ◽  
Dependent Manner ◽  
Tlr4 Expression ◽  
Protein Levels

Background: Nuclear factor kappa B (NF-κB) is usually activated in Wilms tumor (WT) cells and plays a critical role in WT development. Objective: The study purpose was to screen a NF-κB inhibitor from natural product library and explore its effects on WT development. Methods: Luciferase assay was employed to assess the effects of natural chemical son NF-κB activity. CCK-8 assay was conducted to assess cell growth in response to naringenin. WT xenograft model was established to analyze the effect of naringenin in vivo. Quantitative real-time PCR and Western blot were performed to examine the mRNA and protein levels of relative genes, respectively. Results: Naringenin displayed significant inhibitory effect on NF-κB activation in SK-NEP-1 cells. In SK-NEP-1 and G-401 cells, naringenin inhibited p65 phosphorylation. Moreover, naringenin suppressed TNF-α-induced p65 phosphorylation in WT cells. Naringenin inhibited TLR4 expression at both mRNA and protein levels in WT cells. CCK-8 staining showed that naringenin inhibited cell growth of the two above WT cells in dose-and time-dependent manner, whereas Toll-like receptor 4 (TLR4) over expression partially reversed the above phenomena. Besides, naringenin suppressed WT tumor growth in dose-and time-dependent manner in vivo. Western blot found that naringenin inhibited TLR4 expression and p65 phosphorylation in WT xenograft tumors. Conclusion: Naringenin inhibits WT development viasuppressing TLR4/NF-κB signaling

scholarly journals In vivo analysis of the size- and time-dependent uptake of NaYF4:Yb,Er upconversion nanocrystals by pumpkin seedlings

2015 ◽  
Vol 3 (1) ◽  
pp. 144-150 ◽  
Author(s):  
J. Nordmann ◽  
S. Buczka ◽  
B. Voss ◽  
M. Haase ◽  
K. Mummenhoff
Keyword(s):  
Time Dependent ◽  
Upconversion Nanocrystals ◽  
In Vivo Analysis ◽  
Kinetics Of

We have investigated the kinetics of the uptake and the translocation of nanoparticles of different size in plants.

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