A systematic review of moxidectin as a treatment for parasitic infections in mammalian species

2021 ◽  
Vol 120 (4) ◽  
pp. 1167-1181
Author(s):  
Andrea L. Schraven ◽  
Hayley J. Stannard ◽  
Julie M. Old
Keyword(s):  
Systematic Review ◽  
Mammalian Species ◽  
Parasitic Infections

scholarly journals Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (3) ◽  
pp. 862
Author(s):  
Minyahil Tadesse Boltena ◽  
Ziad El-Khatib ◽  
Abraham Sahlemichael Kebede ◽  
Benedict Oppong Asamoah ◽  
Andualem Tadesse Boltena ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Protein Energy Malnutrition ◽  
Random Effect ◽  
Plasmodium Species ◽  
Intestinal Helminth ◽  
Parasitic Infections ◽  
Intestinal Helminths ◽  
Soil Transmitted Helminths ◽  
Pooled Prevalence

Background: Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfections among malaria suspected patients in Ethiopia. Methods: Primary studies published in English language were retrieved using appropriate search terms on Google Scholar, PubMed/MEDLINE, CINHAL, Scopus, and Embase. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for critical appraisal of studies. A pooled statistical meta-analysis was conducted using STATA Version 14.0 software. The heterogeneity and publication bias were assessed using the I2 statistics and Egger’s test, respectively. Duval and Tweedie’s nonparametric trim and fill analysis using the random-effect analysis. The Random effects model was used to estimate the summary prevalence of comorbidity of malaria and soil transmitted helminthiases and the corresponding 95% confidence intervals (CI). The review protocol has registered in PROSPERO number CRD42019144803. Results: We identified ten studies (n = 6633 participants) in this study. The overall pooled result showed 13% of the ambulatory patients infected by malaria and intestinal helminths concurrently in Ethiopia. The pooled prevalence of Plasmodium falciparum and Plasmodium vivax, and mixed infections were 12, 30, and 6%, respectively. The most common intestinal helminth parasites detected were Hookworm, Ascaris lumbricoides, and Tirchuris trichiura. Conclusions: The comorbidity of malaria and intestinal helminths causes lower hemoglobin level leading to maternal anemia, preterm delivery, and still birth in pregnant women and lactating mother. School-aged children and neonates coinfected by plasmodium species and soil transmitted helminths develop cognitive impairment, protein energy malnutrition, low birth weight, small for gestational age, and gross motor delay. The Ministry of Health of Ethiopia and its international partners working on malaria elimination programs should give more emphasis to the effect of the interface of malaria and soil transmitted helminths, which calls for an integrated disease control and prevention.

scholarly journals Intestinal parasites among intellectually disabled individuals in Iran: a systematic review and meta-analysis

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mohammad Javad Abbaszadeh Afshar ◽  
Mehdi Mohebali ◽  
Sina Mohtasebi ◽  
Aref Teimouri ◽  
Bahareh Sedaghat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intestinal Parasites ◽  
Meta Analysis ◽  
Diagnostic Methods ◽  
Personal Hygiene ◽  
Stool Examination ◽  
Parasitic Infections ◽  
Forest Plot ◽  
Intellectually Disabled ◽  
Pooled Prevalence

Abstract Background Poor self-care skills and personal hygiene resulted from limitations in learning and understanding, put intellectually disabled individuals at greater risk for intestinal parasitic infections (IPIs). Despite several regional reports in Iran, the overall burden on IPIs among intellectually disabled individuals is poorly understood. Hence, the present study aimed to estimate the pooled prevalence of IPIs among intellectually disabled individuals in Iran. Methods Using the PRISMA guidelines, we conducted a systematic review and meta-analysis of data retrieved from seven electronic databases (PubMed, Web of Science, Scopus, Embase, and ProQuest for English articles, as well as SID and Magiran for Persian) from their inception up to December 2020. Pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI) and depicted as a forest plot, while heterogeneity was evaluated using Cochran’s Q-test. Results Exactly 1263 of the 3004 intellectually disabled individuals examined by 14 studies across 10 provinces of Iran were positive for IPIs. Overall pooled prevalence estimate was 41% (95% CI 29–53%) with a range of 21% (95% CI 10–32%) to 68% (95% CI 55–80%) across sub-groups. Entamoeba coli (16.2%; 95% CI 10.3–22%), Blastocystis spp. (12.2%; 95% CI 7.2–17.2%), and Giardia duodenalis (11.9%; 95% CI 7.4–16.3%) were the most prevalent protozoan species. In terms of helminthic agents, the most prevalent species were Enterobius vermicularis (11.3%; 95% CI 6.3–16.3%) followed by Strongyloides stercoralis (10.9%; 95% CI 5.0–16.9%) and Hymenolepis nana (2.8%; 95% CI 0.4–5.2%) Conclusion IPIs are highly prevalent among intellectually disabled individuals in Iran. Improving the health status and implementing infectious disease prevention strategies in rehabilitation centers, health promotion interventions to improve personal hygiene of intellectually disabled individuals, as well as utilize sensitive diagnostic methods besides routine stool examination techniques, and treatment of infected individuals will help in the control of these infections among intellectually disabled individuals.

scholarly journals Epidemiology of intestinal parasitic infections in Ethiopian children: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Legese Chelkeba ◽  
Zeleke Mekonnen ◽  
Yonas Alemu ◽  
Daniel Emana
Keyword(s):  
Systematic Review ◽  
Geographical Distribution ◽  
Intestinal Parasites ◽  
Meta Analysis ◽  
School Age Children ◽  
Parasitic Infections ◽  
School Age ◽  
Pooled Prevalence ◽  
Parasite Infections ◽  
Risk Areas

Abstract Background : Numerous studies have been carried out on assessing the prevalence of intestinal parasites infections (IPIs) among preschool and school-age children in Ethiopia, but there is lack of study systematically gathered and analyzedinformation for policymakers. Therefore, the aim of this systematic review and meta-analysis was to provide a summary on prevalence, geographical distribution and trends of IPIs among preschool and school-age childrenin Ethiopia. Methods :The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science, and Google Scholar from 1996to July2019 for studies describing prevalence of IPIs among preschooland school-age children. We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software version 14. Results : Eighty-three(83) studies examining 56,786 fecal specimens were included. The prevalence of IPIs was 48 %( 95%CI: 42% to 53%) and showedsignificantly decreasing trends 17% (95% CI: 2.5% to 32%) for each consecutive 6 years) and was similar in males and females. The pooled prevalence in years 1997–2002, 2003–2008, 2009–2014 and >2014 was 71% (95% CI: 57% to 86%), 42% (95% CI: 27% to 56%), 48% (95% CI: 40% to 56%) and 42% (95% CI: 34% to 49%), respectively. Poly-parasitism was observed in 16% (95% CI: 13% to 19 %,) of the cases. Conclusion: Intestinal parasite infections are highly prevalent among preschool and school-age children and well distributed across the regional states of Ethiopia. Southern and Amhara regional states carry the highest burden.We observed significant decreasing trends in prevalence of IPIs among preschool and school-age Ethiopian children over the last two decades.Therefore, this study is important to locate the geographical distribution and identified high risk areas that should be prioritized further interventions, which complement global efforts towards elimination of IPIs infections by 2020

scholarly journals Prevalence of intestinal parasitic infections in Brazil: a systematic review

2021 ◽  
Vol 54 ◽  
Author(s):  
Ariel Oliveira Celestino ◽  
Sarah Cristina Fontes Vieira ◽  
Pablo Amercio Silva Lima ◽  
Larissa Maria Cardoso Lima Rodrigues ◽  
Isabel Ribeiro Santana Lopes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parasitic Infections ◽  
Intestinal Parasitic Infections

scholarly journals When fever is not malaria in Latin America: a systematic review

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
José Moreira ◽  
Janaina Barros ◽  
Oscar Lapouble ◽  
Marcus V. G. Lacerda ◽  
Ingrid Felger ◽  
...  
Keyword(s):  
Systematic Review ◽  
Latin America ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Fungal Infections ◽  
National Laboratory ◽  
Febrile Illness ◽  
Parasitic Infections ◽  
Surveillance Systems ◽  
Emerging Infections

Abstract Background In malaria-endemic countries, febrile episodes caused by diseases other than malaria are a growing concern. However, limited knowledge of the prevalent etiologic agents and their geographic distributions restrict the ability of health services to address non-malarial morbidity and mortality through effective case management. Here, we review the etiology of fever in Latin America (LA) between 1980 and 2015 and map significant pathogens commonly implicated in febrile infectious diseases. Methods A literature search was conducted, without language restrictions, in three distinct databases in order to identify fever etiology studies that report laboratory-confirmed fever-causing pathogens that were isolated from usually sterile body sites. Data analyses and mapping was conducted with Tableau Desktop (version 2018.2.3). Results Inclusion criteria were met by 625 publications corresponding to data relative to 34 countries. Studies using serology (n = 339) predominated for viral infections, culture (n = 131) for bacteria, and microscopy (n = 62) for fungi and parasites. The pathogen groups most frequently reported were viral infections (n = 277), bacterial infections (n = 265), parasitic infections (n = 59), fungal infections (n = 47), and more than one pathogen group (n = 24). The most frequently reported virus was dengue virus (n = 171), followed by other arboviruses (n = 55), and hantavirus (n = 18). For bacteria, Staphylococcus spp. (n = 82), Rickettsia spp. (n = 70), and Leptospira spp. (n = 55) were frequently reported. Areas with biggest gaps on etiology of fever were apparent. Conclusions This review provides a landscape of pathogens causing febrile illness other than malaria in LA for over 30 years. Our findings highlight the need to standardize protocols and report guidelines for fever etiology studies for better comparability of results and improved interpretation. Lastly, we should improve existing national laboratory surveillance systems, especially from low- to middle-income countries, to inform global fever policy priorities and timely identify emerging infections threats. Study registration PROSPERO systematic review registration number: CRD42016049281

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