Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsae

2005 ◽  
Vol 273 (4) ◽  
pp. 299-310 ◽  
Author(s):  
Richard Jovelin ◽  
Patrick C. Phillips
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Protein Family ◽  
Functional Constraint ◽  
Caenorhabditis Briggsae

Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure in Caenorhabditis elegans

2021 ◽  
Author(s):  
Yunhan Yang ◽  
Qiuli Wu ◽  
Dayong Wang
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Environmental Toxicants ◽  
G Protein Coupled

After the uptake, the environmental toxicants may cause the toxicity on organisms by activating or inhibiting certain G protein-coupled receptors (GPCRs). Nevertheless, the roles of GPCRs in mediating the response...

scholarly journals Drosophila Ana2 is a conserved centriole duplication factor

2010 ◽  
Vol 188 (3) ◽  
pp. 313-323 ◽  
Author(s):  
Naomi R. Stevens ◽  
Jeroen Dobbelaere ◽  
Kathrin Brunk ◽  
Anna Franz ◽  
Jordan W. Raff
Keyword(s):  
Drosophila Melanogaster ◽  
Caenorhabditis Elegans ◽  
De Novo ◽  
Protein Family ◽  
Centriole Duplication

In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP—orthologues of ZYG-1, SAS-6, and SAS-4, respectively—are required for centriole duplication. Strikingly, all three fly proteins can induce the de novo formation of centriole-like structures when overexpressed in unfertilized eggs. Here, we find that of eight candidate duplication factors identified in cultured fly cells, only two, Ana2 and Asterless (Asl), share this ability. Asl is now known to be essential for centriole duplication in flies, but no equivalent protein has been found in worms. We show that Ana2 is the likely functional orthologue of SAS-5 and that it is also related to the vertebrate STIL/SIL protein family that has been linked to microcephaly in humans. We propose that members of the SAS-5/Ana2/STIL family of proteins are key conserved components of the centriole duplication machinery.

Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family

Gene ◽  
2000 ◽  
Vol 256 (1-2) ◽  
pp. 51-58 ◽  
Author(s):  
Manabu Watanabe ◽  
Kenichi Yoshida ◽  
Munetomo Hida ◽  
Hiroyuki Kato ◽  
Kazuyuki Uchida ◽  
...  
Keyword(s):  
G Protein ◽  
Expression Analysis ◽  
Protein Family ◽  
Chromosomal Mapping

Isolation and analysis of the soybean SGA2 gene (cDNA), encoding a new member of the plant G-protein family of signal transducers

1996 ◽  
Vol 32 (6) ◽  
pp. 1227-1234 ◽  
Author(s):  
Cecilia Gotor ◽  
Eric Lam ◽  
Francisco J. Cejudo ◽  
Luis C. Romero
Keyword(s):  
G Protein ◽  
Protein Family ◽  
Signal Transducers

scholarly journals Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (6) ◽  
Author(s):  
Anubhuti Dixit ◽  
Anjali Sandhu ◽  
Souvik Modi ◽  
Meghana Shashikanth ◽  
Sandhya P. Koushika ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Neuronal Control ◽  
G Protein Coupled
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