scholarly journals Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (6) ◽  
Author(s):  
Anubhuti Dixit ◽  
Anjali Sandhu ◽  
Souvik Modi ◽  
Meghana Shashikanth ◽  
Sandhya P. Koushika ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Neuronal Control ◽  
G Protein Coupled

Translational Fusion of a G‐protein Coupled‐Receptor from the Hookworm Ancylostoma ceylanicum Expressed in Caenorhabditis elegans

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Brandon Norman ◽  
Lauren DeLong ◽  
Myra Dickey ◽  
Mollie Jewell ◽  
Patti T. Erickson ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Ancylostoma Ceylanicum ◽  
Translational Fusion ◽  
G Protein Coupled

scholarly journals Identification of a Conserved, Orphan G Protein-Coupled Receptor Required for Efficient Pathogen Clearance in Caenorhabditis elegans

2019 ◽  
Vol 87 (4) ◽  
Author(s):  
Alexandra Anderson ◽  
Yee Lian Chew ◽  
William Schafer ◽  
Rachel McMullan
Keyword(s):  
Caenorhabditis Elegans ◽  
Immune Responses ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled Receptor ◽  
Content Type ◽  
C Elegans ◽  
Host Immune Responses ◽  
Pathogen Clearance ◽  
G Protein Coupled

ABSTRACT G protein-coupled receptors contribute to host defense across the animal kingdom, transducing many signals involved in both vertebrate and invertebrate immune responses. While it has become well established that the nematode worm Caenorhabditis elegans triggers innate immune responses following infection with numerous bacterial, fungal, and viral pathogens, the mechanisms by which C. elegans recognizes these pathogens have remained somewhat more elusive. C. elegans G protein-coupled receptors have been implicated in recognizing pathogen-associated damage and activating downstream host immune responses. Here we identify and characterize a novel G protein-coupled receptor required to regulate the C. elegans response to infection with Microbacterium nematophilum. We show that this receptor, which we designate pathogen clearance-defective receptor 1 (PCDR-1), is required for efficient pathogen clearance following infection. PCDR-1 acts upstream of multiple G proteins, including the C. elegans Gαq ortholog, EGL-30, in rectal epithelial cells to promote pathogen clearance via a novel mechanism.

scholarly journals FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells

Biopolymers ◽  
2007 ◽  
Vol 90 (3) ◽  
pp. 339-348 ◽  
Author(s):  
Teresa M. Kubiak ◽  
Martha J. Larsen ◽  
Jerry W. Bowman ◽  
Timothy G. Geary ◽  
David E. Lowery
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Mammalian Cells ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: Loss of boss causes abnormal energy metabolism

2008 ◽  
Vol 105 (40) ◽  
pp. 15328-15333 ◽  
Author(s):  
Ayako Kohyama-Koganeya ◽  
Yeon-Jeong Kim ◽  
Masayuki Miura ◽  
Yoshio Hirabayashi
Keyword(s):  
Lipid Metabolism ◽  
G Protein ◽  
Insulin Signaling ◽  
Metabolic Regulation ◽  
Transmembrane Domain ◽  
Fat Body ◽  
Nutrient Sensing ◽  
G Protein Coupled Receptor ◽  
Extracellular Glucose ◽  
G Protein Coupled

Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to extracellular glucose and how glucose controls nutrient homeostasis remain unknown. Here, we show that a putative Drosophila melanogaster G protein-coupled receptor, previously identified as Bride of sevenless (BOSS), responds to extracellular glucose and regulates sugar and lipid metabolism. We found that BOSS was expressed in the fat body, a nutrient-sensing tissue equivalent to mammalian liver and adipose tissues, and in photoreceptor cells. Boss null mutants had small bodies, exhibited abnormal sugar and lipid metabolism (elevated circulating sugar and lipid levels, impaired lipid mobilization to oenocytes), and were sensitive to nutrient deprivation stress. These phenotypes are reminiscent of flies defective in insulin signaling. Consistent with these findings are the observations that boss mutants had reduced PI3K activity and phospho-AKT levels, which indicates that BOSS is required for proper insulin signaling. Because human G protein-coupled receptor 5B and the seven-transmembrane domain of BOSS share the same sequence, our results also have important implications for glucose metabolism in humans. Thus, our study provides insight not only into the basic mechanisms of metabolic regulation but also into the pathobiological basis for diabetes and obesity.

scholarly journals NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (5) ◽  
pp. e1006050 ◽  
Author(s):  
Jason C. Campbell ◽  
Lauren F. Polan-Couillard ◽  
Ian D. Chin-Sang ◽  
William G. Bendena
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Multisensory Integration ◽  
Environmental Cues ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The G protein-coupled receptor G2A: Involvement in hepatic lipid metabolism and gallstone formation in mice

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1138-1148 ◽  
Author(s):  
Laura E. Johnson ◽  
Marc S. Elias ◽  
David T. Bolick ◽  
Marcus D. Skaflen ◽  
Richard M. Green ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
G Protein ◽  
Gallstone Formation ◽  
G Protein Coupled Receptor ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
G Protein Coupled

Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans

2005 ◽  
Vol 330 (3) ◽  
pp. 967-974 ◽  
Author(s):  
Inge Mertens ◽  
Tom Meeusen ◽  
Tom Janssen ◽  
Ronald Nachman ◽  
Liliane Schoofs
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
Molecular Characterization ◽  
Splice Variants ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G protein–coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress

2020 ◽  
Vol 26 (1) ◽  
pp. 187-197
Author(s):  
Stacy A. Henry ◽  
Selina Crivello ◽  
Tina M. Nguyen ◽  
Magdalena Cybulska ◽  
Ngoc S. Hoang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles in Caenorhabditis elegans

2021 ◽  
Author(s):  
Yunhan Yang ◽  
Wenting Dong ◽  
Qiuli Wu ◽  
Dayong Wang
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Polystyrene Nanoparticles ◽  
G Protein Coupled

The deposition of certain amount of nanopolystyrene (NPS) could be observed in gonad of Caenorhabditis elegans. However, we still know little about the response of germline to NPS exposure. In...

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