scholarly journals Neural crest stem cells protect spinal cord neurons from excitotoxic damage and inhibit glial activation by secretion of brain-derived neurotrophic factor

2018 ◽  
Vol 372 (3) ◽  
pp. 493-505 ◽  
Author(s):  
Nikos Schizas ◽  
N. König ◽  
B. Andersson ◽  
S. Vasylovska ◽  
J. Hoeber ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Crest ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Glial Activation ◽  
Spinal Cord Neurons ◽  
Neural Crest Stem Cells ◽  
Excitotoxic Damage

scholarly journals Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?

Stem Cells ◽  
2014 ◽  
Vol 32 (4) ◽  
pp. 829-843 ◽  
Author(s):  
Virginie Neirinckx ◽  
Dorothée Cantinieaux ◽  
Cécile Coste ◽  
Bernard Rogister ◽  
Rachelle Franzen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Crest ◽  
Spinal Cord Injuries ◽  
Neural Crest Stem Cells ◽  
Concise Review

scholarly journals Human Brain–Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury

Dose-Response ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 155932582091093
Author(s):  
YongLei Li ◽  
Hongchen Wang ◽  
Xiaofang Ding ◽  
Jiancheng Shen ◽  
Haitao Zhou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Factor Gene ◽  
Cord Injury ◽  
Marrow Mesenchymal Stem Cells

Objective: To assess the effect as well as mechanism of bone marrow mesenchymal stem cells (BMSCs) modified by the human brain–derived neurotrophic factor gene combined with erythropoietin (EPO) in the treatment of acute spinal cord injury (SCI) in rats. Methods: The Brain-derived neurotrophic factor (BDNF) gene was transected by a virus vector. Rats with SCI were randomly split into following groups: The normal saline (NS) group, the EPO group, The Basso, Beattie, and Bresnahan scores, messenger RNA BDNF expression, and apoptosis rates were compared between the 4 groups at 1, 3, 7, 14, and 21 days after SCI. Results: At 7, 14, and 21 days after operation, the expression of the BDNF gene in the other 3 groups was higher than that of the NS group, and the difference was statistically significant ( P < .05). The apoptosis rate in the combined group was less than that of NS, EPO, and BDNF/BMSC groups, and the differences were statistically significant ( P < .05). Conclusion: Brain-derived neurotrophic factor gene-modified BMSC transplantation combined with EPO can promote the repair of nerve function after SCI in rats.

scholarly journals The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Donghe Han ◽  
Shurui Chen ◽  
Shiqiang Fang ◽  
Shiqiong Liu ◽  
Meihua Jin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neurotrophic Factor ◽  
Neuron Specific Enolase ◽  
Brain Derived Neurotrophic Factor ◽  
Related Factor ◽  
Neuroprotective Effects ◽  
Cord Injury ◽  
Neuron Injury

Muscle-derived stem cells (MDSCs) possess multipotent differentiation and self-renewal capacities; however, the effects and mechanism in neuron injury remain unclear. The aim of this study was to investigate the effects of MDSCs on neuron secondary injury, oxidative stress-induced apoptosis. An in vivo study showed the Basso, Beattie, and Bresnahan (BBB) score and number of neurons significantly increased after MDSCs’ transplantation in spinal cord injury (SCI) rats. An in vitro study demonstrated that MDSCs attenuated neuron apoptosis, and the expression of antioxidants was upregulated as well as the ratio of Bcl-2 and Bax in the MNT (MDSCs cocultured with injured neurons) group compared with the NT (injured neurons) group. Both LC3II/LC3I andβ-catenin were enhanced in the MNT group, while XAV939 (aβ-catenin inhibitor) decreased the expression of nuclear erythroid-related factor 2 (Nrf2) and LC3II/LC3I. Moreover, MDSCs became NSE- (neuron-specific enolase-) positive neuron-like cells with brain-derived neurotrophic factor (BDNF) treatment. The correlation analysis indicated that there was a significant relation between the level of BDNF and neuron injury. These findings suggest that MDSCs may protect the spinal cord from injury by inhibiting apoptosis and replacing injured neurons, and the increased BDNF andβ-catenin could contribute to MDSCs’ effects.

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