Loss of Nucleobindin-2/Nesfatin-1 increases lipopolysaccharide-induced murine acute lung inflammation

2021 ◽  
Author(s):  
Jasmine Hui ◽  
Gurpreet Kaur Aulakh ◽  
Suraj Unniappan ◽  
Baljit Singh
Keyword(s):  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 180
Author(s):  
Maud Weiss ◽  
Jiahui Fan ◽  
Mickaël Claudel ◽  
Luc Lebeau ◽  
Françoise Pons ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Lung Inflammation ◽  
Adverse Outcome ◽  
Cellular Responses ◽  
Target Cells ◽  
Inflammasome Activation ◽  
Adverse Outcome Pathway ◽  
Acute Lung Inflammation

With the growth of nanotechnologies, concerns raised regarding the potential adverse effects of nanoparticles (NPs), especially on the respiratory tract. Adverse outcome pathways (AOP) have become recently the subject of intensive studies in order to get a better understanding of the mechanisms of NP toxicity, and hence hopefully predict the health risks associated with NP exposure. Herein, we propose a putative AOP for the lung toxicity of NPs using emerging nanomaterials called carbon dots (CDs), and in vivo and in vitro experimental approaches. We first investigated the effect of a single administration of CDs on mouse airways. We showed that CDs induce an acute lung inflammation and identified airway macrophages as target cells of CDs. Then, we studied the cellular responses induced by CDs in an in vitro model of macrophages. We observed that CDs are internalized by these cells (molecular initial event) and induce a series of key events, including loss of lysosomal integrity and mitochondrial disruption (organelle responses), as well as oxidative stress, inflammasome activation, inflammatory cytokine upregulation and macrophage death (cellular responses). All these effects triggering lung inflammation as tissular response may lead to acute lung injury.

scholarly journals Blockade of Secondary Lymphoid Tissue Chemokine ExacerbatesPropionibacterium acnes-Induced Acute Lung Inflammation

2001 ◽  
Vol 166 (3) ◽  
pp. 2071-2079 ◽  
Author(s):  
Meiji Itakura ◽  
Atsuko Tokuda ◽  
Hiroshi Kimura ◽  
Shigenori Nagai ◽  
Hiroyuki Yoneyama ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Lung Inflammation ◽  
Acute Lung Inflammation ◽  
Secondary Lymphoid Tissue

scholarly journals Pulmonary Endothelial Protein Kinase C-Delta (PKCδ) Regulates Neutrophil Migration in Acute Lung Inflammation

2014 ◽  
Vol 184 (1) ◽  
pp. 200-213 ◽  
Author(s):  
Mark J. Mondrinos ◽  
Ting Zhang ◽  
Shuang Sun ◽  
Paul A. Kennedy ◽  
Devon J. King ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Lung Inflammation ◽  
Neutrophil Migration ◽  
Acute Lung Inflammation ◽  
Protein Kinase C Delta ◽  
Kinase C

scholarly journals Early Detection of Susceptibility to Acute Lung Inflammation by Molecular Imaging in Mice Exposed to Cigarette Smoke

2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2011.00010 ◽  
Author(s):  
Sandra Pérez-Rial ◽  
Laura del Puerto-Nevado ◽  
Nicolás González-Mangado ◽  
Germán Peces-Barba
Keyword(s):  
Molecular Imaging ◽  
Early Detection ◽  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Raymond LC Kao ◽  
Xuemei Xu ◽  
Anargyros Xenocostas ◽  
Neil Parry ◽  
Tina Mele ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation

2019 ◽  
Vol 55 (11) ◽  
pp. 573-580 ◽  
Author(s):  
Jaime Eduardo Davino-Chiovatto ◽  
Manoel Carneiro Oliveira-Junior ◽  
BreAnne MacKenzie ◽  
Alana Santos-Dias ◽  
Ana Roberta Almeida-Oliveira ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Lung Inflammation ◽  
Neutrophil Activation ◽  
Acute Lung Inflammation

Blockade of protease-activated receptor 2 attenuates allergen-mediated acute lung inflammation and leukocyte recruitment in mice

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Natália Alves de Matos ◽  
Onésia Cristina Oliveira Lima ◽  
Josiane Fernandes da Silva ◽  
Annie Rocio Piñeros ◽  
Juliana Carvalho Tavares ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Leukocyte Recruitment ◽  
Acute Lung Inflammation ◽  
Protease Activated Receptor 2

scholarly journals Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e108914 ◽  
Author(s):  
Yang Xu ◽  
Toshihiro Ito ◽  
Soichiro Fushimi ◽  
Sakuma Takahashi ◽  
Junya Itakura ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Acute Lung Inflammation
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