Oxidant stress in primary nephrotic syndrome: does it modulate the response to corticosteroids?

2009 ◽  
Vol 24 (12) ◽  
pp. 2375-2380 ◽  
Author(s):  
Ashraf Bakr ◽  
Sami Abul Hassan ◽  
Mohamed Shoker ◽  
Mayssa Zaki ◽  
Rasha Hassan
Keyword(s):  
Nephrotic Syndrome ◽  
Oxidant Stress ◽  
Primary Nephrotic Syndrome

STEROID THERAPY EFFICACY FOR PRIMARY NEPHROTIC SYNDROME DEBUT IN CHILDREN

2018 ◽  
Vol 97 (5) ◽  
pp. 61-66
Author(s):  
T.L. Nastausheva ◽  
◽  
O.A. Zhdanova ◽  
G.A. Batishcheva ◽  
Yu.N. Chernov ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Therapy ◽  
Primary Nephrotic Syndrome ◽  
Therapy Efficacy

Primary nephrotic syndrome of childhood

1996 ◽  
Vol 8 (2) ◽  
pp. 141-147 ◽  
Author(s):  
H. William Schnaper
Keyword(s):  
Nephrotic Syndrome ◽  
Primary Nephrotic Syndrome

Sister chromatid exchange analysis in monitoring chlorambucil therapy in primary nephrotic syndrome of childhood

1991 ◽  
Vol 5 (1) ◽  
pp. 59-61 ◽  
Author(s):  
A. Y. Elzouki ◽  
K. Al-Nassar ◽  
M. Al-Ali ◽  
G. Malik ◽  
F. Elsharie ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Primary Nephrotic Syndrome

Markers of steroid resistance of the primary nephrotic syndrome in children

2021 ◽  
Vol 19 (1) ◽  
pp. 15-21
Author(s):  
S. L. Morozov ◽  
◽  
V. V. Dlin ◽  
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Therapy ◽  
Molecular Genetic ◽  
Clinical Importance ◽  
Recent Decade ◽  
Immunosuppressive Drugs ◽  
Steroid Resistance ◽  
Primary Nephrotic Syndrome ◽  
Non Invasive ◽  
The Common

The global task of the recent decade is to search for clinical and laboratory markers accurately showing a patient’s reaction to steroid therapy and other immunosuppressive drugs. It is important the applied methods and tests to be non-invasive and simple to use. The article considers various biomarkers used to verify the type of nephrotic syndrome depending on the sensitivity to steroid therapy. Besides the common markers, which are used in clinical practice or have shown a significant result, the work highlights the molecular- genetic markers of resistance to steroid therapy, which are of special clinical importance today. Also, the article presents authors’ own results in diagnosing the steroid resistance of the primary nephrotic syndrome.

Abnormal Lipid Metabolism in Primary Nephrotic Syndrome

1987 ◽  
pp. 33-43
Author(s):  
Gaston Zilleruelo ◽  
S. L. Hsia ◽  
Michael Freundlich ◽  
Carolyn Abitbol ◽  
Milan Novak ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Lipid Metabolism ◽  
Primary Nephrotic Syndrome ◽  
Abnormal Lipid Metabolism

scholarly journals Evaluating the Quality of Life of 231 Children With Primary Nephrotic Syndrome and Assessing Parental Awareness of the Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Na Li ◽  
Jia Hao ◽  
Tong Fu ◽  
Yue Du
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Sleep Disturbances ◽  
Integrated Management ◽  
Psychological Wellbeing ◽  
Average Score ◽  
Online Questionnaire ◽  
Primary Nephrotic Syndrome ◽  
Making Friends

Objective: This study aims to investigate the quality of life of children with primary nephrotic syndrome (PNS), assess their parents' disease awareness, and provide a basis for the comprehensive management of children with PNS.Methods: A total of 231 children with PNS who were hospitalized in the Department of Pediatric Renal Rheumatology and Immunology in the ShengJing Hospital of the China Medical University from March 2019 to October 2020 were selected as the study subjects. The subjects and their parents were surveyed via a disease education and communication WeChat group and online questionnaire to investigate the children's quality of life, the needs of the parents, and their knowledge related to the disease.Results: In 93.51% of cases, the child's quality of life was affected, with mild to moderate effects being the most frequent (90.47%). The lowest overall quality of life scores were recorded for children who had been diagnosed 1–3 year prior to inclusion in the study, and the scores plateaued thereafter. On the physical functioning scale, the longer the illness, the greater the physical impact, with children typically experiencing pain and fatigue. The children generally scored low on the emotional functioning scale, exhibiting sleep disturbances for up to 5 years and worrying about accidents. The children's average score on the social functioning scale was high, with males achieving significantly higher scores (69.61 ± 25.42) than females (62.30 ± 27.51), and more than one-third of the children experiencing problems getting along with other teenagers and making friends. The primary problems expressed by parents were anxiety (59%), sadness (44%), fear (43%), and depression (40%), and several parents indicated that they struggled with issues of self-blame.Conclusion: PNS impacts the physical and psychological wellbeing of children suffering from the condition, significantly reduces their quality of life, and negatively impacts the psychological wellbeing of their parents. Therefore, children with PNS and their families need integrated management by doctors, nurses, dieticians, psychotherapists, educational institutions, and social stakeholders to improve their quality of life.

Sign in / Sign up

Export Citation Format

Share Document