scholarly journals IgA nephropathy presenting as rapidly progressive glomerulonephritis following first dose of COVID-19 vaccine

2021 ◽  
Author(s):  
Olivier Niel ◽  
Cosmin Florescu
Keyword(s):  
Iga Nephropathy ◽  
Rapidly Progressive Glomerulonephritis

Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis

1991 ◽  
Vol 81 (s25) ◽  
pp. 477-481 ◽  
Author(s):  
K. Lhotta ◽  
H. P. Neumayer ◽  
M. Joannidis ◽  
D. Geissler ◽  
P. KöNig
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Adhesion Molecule ◽  
Membranoproliferative Glomerulonephritis ◽  
Rapidly Progressive Glomerulonephritis ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Segmental Glomerulosclerosis ◽  
Mesangioproliferative Glomerulonephritis

1. Expression of intercellular adhesion molecule-1 was investigated in five normal kidneys and 47 renal biopsies with the use of monoclonal antibody 7F7 and immunoperoxidase staining. 2. In the normal kidney, intercellular adhesion molecule-1 was expressed on endothelial cells of glomerular and peritubular capillaries, on Bowman's capsule, on some interstitial cells and weakly in the mesangium. 3. Increased glomerular staining was detected in early cases of rapidly progressing glomerulonephritis (5/8) and in some cases of non-IgA mesangioproliferative glomerulonephritis (5/9), IgA nephropathy (3/5), Henoch-Schoenlein purpura (2/2), lupus nephritis (5/6) and focal segmental glomerulosclerosis (1/3). A decrease in intercellular adhesion molecule-1 expression was noted in advanced rapidly progressive glomerulonephritis (3/8), two cases of membraneous nephropathy, one severe mesangioproliferative glomerulonephritis biopsy, the two membranoproliferative glomerulonephritis biopsies and in sclerotic loops in focal segmental glomerulosclerosis. 4. Expression de novo on tubular epithelial cells occurred in rapidly progressive glomerulonephritis, in membranoproliferative glomerulonephritis, and to a lesser extent in some cases of membranous nephropathy, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, a severe case of mesangioproliferative glomerulonephritis and in the mixed essential cryoglobulinaemia case. In 63% of positive tubuli, intraluminal cells which expressed CD18, the common β-chain of leucocyte-function-associated antigen-1, Mac-1 and p150,95, were present. 5. Intercellular adhesion molecule-1 was also found on the majority (59%) of infiltrating mononuclear cells in all forms of glomerulonephritis.

PATHOLOGY AND RENAL OUTCOME OF THREE UNCOMMON FACES OF CRESCENTRIC GLOMERULONEPHRITIS

2021 ◽  
pp. 7-12
Author(s):  
Keya Basu ◽  
Dipankar Sircar ◽  
Manimoy Bandopadhyay
Keyword(s):  
Iga Nephropathy ◽  
Survival Data ◽  
Periodic Acid ◽  
Rapidly Progressive Glomerulonephritis ◽  
Renal Outcome ◽  
Single Centre ◽  
Periodic Acid Schiff ◽  
Cross Sectional ◽  
Single Centre Study ◽  
Hematoxylin Eosin

AIMS: Rapidly progressive glomerulonephritis (RPGN) presents with rapidly deteriorating renal function (> 50% loss of glomerular ltration rate /GFR within 3 months) associated with nephritic urinary sediments and crescents in biopsy. Crescentric IgA Nephropathy, Anti-GBM (Glomerular basement membrane) disease and combined IgA Nephropathy with Anti-GBM disease are three uncommon reasons of RPGN. We have compared clinicopathological. Immunouorescence (DIF) and renal outcome of three groups. Setting and designs: Prospective, cross-sectional, single centre study. METHODS AND MATERIALS :Ultrasonography guided core biopsies obtained, one stained with hematoxylin-eosin, periodic acid-Schiff, Masson's trichrome, and silver methenamine stain another one with immunouorescence conjugated IgG, IgM, IgA, C3, C1q, kappa and lambda stain. Demographic, clinicopathological and therapeutic parameters with survival data were collected. STATISTICAL ANALYSIS USED: Done using software (GraphPad PRISM 6). RESULTS: We have included 9 cases of crescentric IgA Nephropathies, 6 cases of AntiGBM diseases and 2 cases of combined IgA Nephropathy and AntiGBM diseases. Signicant difference seen in the incidences of hypertension, hemoptysis, serum creatinine, anti GBM antibody, total number of crescents and mesangial hypercellularity, fragmentation of GBM etc. IgG, IgA and kappa positivity in DIF show signicant difference. Survival analysis and mortality versus dialysis dependence and complete and partial remission versus no remission showed no difference between these three groups. CONCLUSIONS: Proper and early clinicopathological diagnosis is important since all are of poor renal outcome. Further renal outcome of the combined disease is same as that of individual ones.

A case of IgA nephropathy associated with mycosis fungoides that developed into rapidly progressive glomerulonephritis

2013 ◽  
Vol 79 (02) ◽  
pp. 161-165 ◽  
Author(s):  
Masaki Hara ◽  
Tetsuo Nemoto ◽  
Tsunekazu Hijima ◽  
Ken Tsuchiya ◽  
Kosaku Nitta ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Mycosis Fungoides ◽  
Rapidly Progressive Glomerulonephritis

scholarly journals IgA nephropathy and atypical anti GBM disease: A rare dual pathology in a pediatric RPGN

2021 ◽  
Author(s):  
Varun Bajaj ◽  
Shilpi Thakur ◽  
Adarsh Barwad ◽  
Aditi Sinha ◽  
Arvind Bagga ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Rapidly Progressive Glomerulonephritis ◽  
Age Group ◽  
Case Presentation ◽  
Plasma Exchange Therapy ◽  
Dual Pathology ◽  
Pediatric Age Group ◽  
Disease Case ◽  
Iga Antibodies

Introduction: Anti-GBM nephritis in the pediatric age group is exceedingly rare with concurrent additional pathologies being even rarer. Tissue diagnosis requires a combination of crescentic histomorphology, immunofluorescence showing “Paint brush stroke” pattern of linear IgG or rarely IgA and serum anti-GBM antibodies subject to the disease course and treatment. The authors describe one such case with a dual pathology involving IgA nephropathy and atypical anti-GBM disease. Case presentation: A thirteen-year-old girl presenting with features of rapidly progressive glomerulonephritis underwent a renal biopsy showing a mesangioproliferative histology with crescents and an immunofluorescence pattern indicating a dual pathology of IgA Nephropathy and Anti GBM Nephritis. Additional ancillary testing including staining for IgG subclasses and galactose deficient IgA (KM55) helped to confirm the diagnosis. She responded to steroid pulses and plasma exchange therapy, was off dialysis after 8 weeks with serum creatinine of 1.5 mg/dl however remains proteinuric at last follow up. Conclusion: Concurrent Anti-GBM nephritis and IgA nephropathy is a rare occurrence and possibly arises from a complex interaction between the anti-GBM antibodies and the basement membrane unmasking the antigens for IgA antibodies. Additional newer techniques like immunofluorescence for KM 55 are helpful in establishing the dual pathology.

scholarly journals P0493EPIDEMIOLOGY OF IGA NEPHROPATHY IN THE MALTESE ISLANDS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Abigail Attard ◽  
Diana Vassallo ◽  
John Swayne ◽  
Jesmar Buttigieg ◽  
Edward Grech ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Kidney Disease ◽  
Observational Study ◽  
Iga Nephropathy ◽  
Laboratory Data ◽  
Rapidly Progressive Glomerulonephritis ◽  
Kidney Injury ◽  
Maltese Islands ◽  
History Of

Abstract Background and Aims IgA nephropathy is the most common cause of glomerular disease worldwide. Natural history and clinical progression of this condition are highly heterogenous and can vary from asymptomatic haematoproteinuria, to a rapidly progressive glomerulonephritis that results in end-stage kidney disease (ESKD). The OXFORD MEST-C score is a set of consensus criteria that have been correlated with renal outcomes independent of baseline clinical features, proteinuria and blood pressure control. This is the first observational study carried out in the Maltese Islands that aims to evaluate the epidemiology and the histopathological distribution in Malta. Method All patients with biopsy-proven IgA nephropathy between January 2013 and July 2019 in our centre were recruited into this longitudinal retrospective observational study. Baseline data at time of biopsy included demographics, laboratory data and the MEST-C score. Study end-points included death, doubling of serum creatinine and ESKD. Data was censored on 31/12/2019. Results A total of 46 patients were recorded over this 6 year period, with a median follow-up of 2.7 years (Standard deviation 1.9). The median age of our cohort at time of biopsy was 46.1 years (Standard deviation 16.1). In total, 71.7% were males, 34.8% were hypertensive and 6.5% diabetic at baseline. At time of biopsy, 89.1% had an active sediment, 54.3% had established chronic kidney disease (CKD), 17.4% presented with acute kidney injury (AKI), 13% had a history of synpharyngitic haematuria, while 4.3% had a history of Henoch–Schönlein (HSP). In our cohort, 8 patients (17.4%) had progression of CKD. 4 of them had doubling of creatinine with 3 reaching ESKD. 1 patient died. Table 1 shows the distribution of histopathological findings in our cohort: Conclusion Despite the limited study sample, short follow-up time, and absence of treatment data, our results demonstrate that the distribution of histopathological variants in our cohort is similar to that reported elsewhere in the literature1. Barbour SJ, Espino-Hernandez G, Reich HN, Coppo R, Roberts IS, Feehally J, et al. The MEST score provides earlier risk prediction in IgA nephropathy. Kidney Int. 2016 Jan;89(1):167–75.

Interstitial inflammation and the expression of apoptotic modulators in iga nephropathy

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A114-A114
Author(s):  
Menahem Sa ◽  
Maguire Ja ◽  
Stein‐Oakley A ◽  
Bailey M ◽  
Dowling J ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Interstitial Inflammation
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