Technical innovation for noninvasive and early diagnosis of biliary atresia: the ultrasonographic "triangular cord" sign

2001 ◽  
Vol 8 (4) ◽  
pp. 337-341 ◽  
Author(s):  
Woo-Hyun Park ◽  
Soon-Ok Choi ◽  
Hee-Jung Lee
Keyword(s):  
Early Diagnosis ◽  
Biliary Atresia ◽  
Technical Innovation

scholarly journals How to evaluate diagnosis and management of biliary atresia in the era of liver Transplantation in China

2018 ◽  
Vol 1 (1) ◽  
pp. e000002
Author(s):  
Jianghua Zhan ◽  
Yajun Chen ◽  
Kenneth K Y Wong
Keyword(s):  
Liver Transplantation ◽  
Survival Rate ◽  
Early Diagnosis ◽  
Biliary Atresia ◽  
Further Education ◽  
Monitoring Methods ◽  
Kasai Operation ◽  
First Choice ◽  
Choice Of Treatment ◽  
Hepatobiliary Diseases

BackgroundBiliary atresia (BA) is one of the most challenging hepatobiliary diseases in children. Notwithstanding the reasonable outcome of liver transplantation (LT), portoenteral anastomosis (Kasai operation) is still the first choice of treatment for patients with BA. How to improve the survival rate of the patients with BA in the era of LT is a new challenge.Data sourcesBased on recent original publications and the experience with the BA in China, we review many factors that influence BA survival situation, including early diagnosis and screen plan, defects of early treatment, Kasai operation, and LT and indicate present questions about BA diagnosis and treatment in China.ResultsBA diagnosis may also be delayed due to insufficient understanding of BA and lack of jaundice monitoring methods at different levels of the hospitals in China. Further education of the physicians at smaller city hospitals about BA, neonatal jaundice and cholestasis would be helpful in improving early diagnosis of BA. Early surgical intervention is still the only guarantee to improve the survival rate of BA with native liver.ConclusionsIn the era of LT, especially in China, Kasai operation can provide waiting time for living donor LT and improve the success rate of LT and minimize the rapid deterioration of liver function of the children with BA and decrease the mortality in patients with BA.

scholarly journals Early Diagnosis of Extrahepatic Biliary Atresia in an Open-Access Medical System

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49643 ◽  
Author(s):  
Justin Hollon ◽  
Matilda Eide ◽  
Gregory Gorman
Keyword(s):  
Open Access ◽  
Early Diagnosis ◽  
Biliary Atresia ◽  
Medical System ◽  
Extrahepatic Biliary Atresia

The Role of Endoscopic Retrograde Cholangiopancreatography in the Diagnosis of Biliary Atresia: 14 Years' Experience

2017 ◽  
Vol 28 (03) ◽  
pp. 261-267 ◽  
Author(s):  
Ahmed Negm ◽  
Claus Petersen ◽  
Andrea Markowski ◽  
Birgit Luettig ◽  
Kristina Ringe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Diagnosis ◽  
Liver Biopsy ◽  
Biliary Atresia ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Predictive Value ◽  
Neonatal Cholestasis ◽  
Endoscopic Retrograde ◽  
Ultrasound Findings

Introduction Biliary atresia (BA) is a rare destructive inflammatory obliterative cholangiopathy of neonates. Early diagnosis is important in disease management. The aim was to evaluate the role of endoscopic retrograde cholangiopancreatography (ERCP) in diagnosing BA in a large cohort. In addition, we evaluated whether parameters such as bile trace, GGT, bilirubin, and laboratory values in combination can be used to develop a risk score that could indicate the referral to specialized centers. Materials and Methods All infants with neonatal cholestasis (2000–2014) who presented to our endoscopy unit for suspected BA were included. Demographics, laboratory parameters, ultrasound findings, liver biopsy results, ERCP diagnosis, and surgical outcome were collected. Value and safety of ERCP and risk factors for BA were retrospectively analyzed. Results We included 251 infants in our cohort (55% males, median age: 53 days). BA was intraoperatively diagnosed in 155 (83.4%) patients and was excluded in 30 (16.2%). Fifty-six cases were not operated due to the ERCP findings. ERCP was successful in 224/251 patients (89.2%) with no procedure-related complications. The operative and endoscopic diagnosis matched in 96.6% of the patients (positive predictive value: 92.2%, negative predictive value: 97.1%). In comparison to cases with excluded BA, the ones with this disease were significantly associated with absence of duodenal bile traces (98.4 vs. 1.6%, p < 0.001), higher bilirubin (p < 0.001, cutoff 7.3 mg/dL), and higher GGT (p < 0.001, cutoff 250 U/L). Conclusion ERCP is safe and accurate in the hands of experts in diagnosing BA if the cause of cholestasis is unclear. While evaluating the role of ERCP for diagnosing this disease, we found that the secondary parameters GGT > 250 U/L, bilirubin > 7.3 mg/dL (125 μmol/L), and the absence of bile traces are risk factors.

The “hepatic subcapsular flow sign” in early diagnosis of biliary atresia

2019 ◽  
Vol 44 (9) ◽  
pp. 3200-3202 ◽  
Author(s):  
Vincenzo Carollo ◽  
Mariapina Milazzo ◽  
Roberto Miraglia
Keyword(s):  
Early Diagnosis ◽  
Biliary Atresia

scholarly journals MODERN APPROACHES TO THE SURGICAL TREATMENT OF BILIARY ATRESIA

2018 ◽  
Vol 8 (3) ◽  
pp. 100-111 ◽  
Author(s):  
A. Yu. Razumovskiy ◽  
S. A. Ratnikov
Keyword(s):  
Surgical Treatment ◽  
Early Diagnosis ◽  
Biliary Atresia ◽  
Google Scholar ◽  
Review Of Literature ◽  
Search System ◽  
Pubmed Database ◽  
Current Classification

The review of literature deals with the current classification of the biliary atresia, presents the authors’ opinion considering a technique of theKasaiprocedure, and displays modern modifications of portoenteroanastomosis estimating their effectiveness. PubMed database and Google Scholar search system were used to search for primary terms. Survival of children with this pathology was analyzed depending on theKasaitechnique, anatomical form, terms of portoenteroanastomosis and importance of early diagnosis of this pathology. 

scholarly journals FEATURES OF DIAGNOSIS OF BILIARY ATRESIA IN CHILDREN

2019 ◽  
Vol 20 (2) ◽  
pp. 79-84
Author(s):  
G. V. Volynets ◽  
A. V. Nikitin ◽  
T. A. Skvortsova ◽  
A. S. Potapov ◽  
A. K. Gevorkyan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Statistical Analysis ◽  
Early Diagnosis ◽  
Biliary Atresia ◽  
Diagnostic Tests ◽  
Liver Tissue ◽  
Diagnostic Algorithm ◽  
Early Age ◽  
Diagnostic Indices ◽  
Clinical Diagnostic

Early diagnosis of biliary atresia in children is important. Diagnosis of biliary atresia is necessary in the first 2-3 months of life, when there is occurred cirrhotic transformation of the liver tissue and there is an alternative for treatment tactics that is more appropriate than liver transplantation. In this case the diagnostic algorithm of diseases accompanied by cholestasis is rather complicated and based on data of clinical diagnostic tests. There are presented data of the retrospective analysis of the course of the disease in 20 children (14 boys and 6 girls) with biliary atresia and multifactorial statistical analysis of clinical-diagnostic indices of the onset of the disease on the basis of the algorithm for step-by-step diagnosis of biliary atresia in children of early age

Biliary atresia: Early diagnosis through operative cholangiography

1986 ◽  
Vol 53 (6) ◽  
pp. 807-810
Author(s):  
Rekha H. Udani ◽  
Jyotsana M. Kirtane
Keyword(s):  
Early Diagnosis ◽  
Biliary Atresia ◽  
Operative Cholangiography

Morphometric assessment of liver fibrosis may enhance early diagnosis of biliary atresia

2013 ◽  
Vol 9 (4) ◽  
pp. 330-335 ◽  
Author(s):  
Ahmed F. Abdalla ◽  
Abeer Fathy ◽  
Khaled R. Zalata ◽  
Ahmed Megahed ◽  
Ahmed Abo-Alyazeed ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Early Diagnosis ◽  
Biliary Atresia ◽  
Morphometric Assessment
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