scholarly journals Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

2008 ◽  
Vol 17 (11) ◽  
pp. 1407-1422 ◽  
Author(s):  
Tue Secher Jensen ◽  
Jaro Karppinen ◽  
Joan S. Sorensen ◽  
Jaakko Niinimäki ◽  
Charlotte Leboeuf-Yde
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Low Back ◽  
Modic Change ◽  
Vertebral Endplate ◽  
Signal Changes

scholarly journals ASSOCIATION OF LOW BACK PAIN AND SCIATICA WITH SIGNAL CHANGES IN THE VERTEBRAL ENDPLATE

2020 ◽  
Vol 19 (3) ◽  
pp. 213-217
Author(s):  
ALBERTO OFENHEJM GOTFRYD ◽  
DÉLIO EULÁLIO MARTINS FILHO ◽  
MARCELO WAJCHENBERG ◽  
MICHEL KANAS ◽  
SAULO DE TARSO DE SÁ PEREIRA SEGUNDO ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Type I ◽  
Low Back ◽  
Vertebral Endplate ◽  
Level Of Evidence ◽  
Signal Changes ◽  
Treatment Responses

ABSTRACT Objective To evaluate whether vertebral endplate signal changes (VESCs) influence the prognosis of patients submitted to conservative or surgical treatment for low back pain and lumbosciatica. Methods Study with 241 patients who underwent conservative treatment, infiltration or surgery with 12 months of follow-up. They were evaluated for pain by the Visual Analog Scale for Pain (VAS), for function by the Roland Morris questionnaire and for quality of life by the EuroQoI5 (EQ-5D). Results The VESCs did not have a significant effect on the treatment responses for the VAS (F = 0.03; P = 0.97), Roland Morris (F = 0.51; P = 0.60) and EQ-5D (F = 2.67; P = 0.07) variables, nor was there any interaction between VESC and treatment for VAS (F = 2.15; P = 0.08), Roland Morris (F = 1.55; P = 0.19) and EQ-5D (F = 2.15; P = 0.08). There was a significant effect for all treatments, however, the effect of the surgical procedure was superior when compared to the others (P <0.001). The VESC frequency was 48.33% for type 0, 29.17% for type I and 22.50% for type II. Conclusions The presence of VESC and its different types is not associated with a worse prognosis, nor was a higher prevalence of VESC observed in the patients with low back pain and lumbosciatica. Level of Evidence II; Retrospective cohort study.

Clinical efficacy and safety of eperisone for low back pain: A systematic literature review

2016 ◽  
Vol 68 (5) ◽  
pp. 903-912 ◽  
Author(s):  
Sachin Bavage ◽  
Sharanbasappa Durg ◽  
Shoukath Ali Kareem ◽  
Shivsharan B. Dhadde
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Literature Review ◽  
Clinical Efficacy ◽  
Systematic Literature Review ◽  
Low Back ◽  
Efficacy And Safety

Assessment of Ankylosing Spondylitis Criteria in Patients with Chronic Low Back Pain and Vertebral Endplate Modic I Signal Changes

2010 ◽  
Vol 37 (11) ◽  
pp. 2334-2339 ◽  
Author(s):  
CHRISTELLE NGUYEN ◽  
IMAD BENDEDDOUCHE ◽  
KATHERINE SANCHEZ ◽  
MARYLÈNE JOUSSE ◽  
AGATHE PAPELARD ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Chronic Low Back Pain ◽  
Tertiary Care ◽  
Low Back ◽  
Hla B27 ◽  
Vertebral Endplate ◽  
Mri Findings ◽  
Signal Changes

Objective.Patients with chronic low back pain (cLBP) and vertebral endplate Modic I signal changes on lumbar magnetic resonance imaging (MRI) have clinical features that could mimic inflammatory back pain related to spondyloarthritis (SpA) and/or ankylosing spondylitis (AS). We aimed to assess whether such patients fulfilled criteria for SpA and/or AS.Methods.For 5 months in 2008, all patients (n = 314) referred to a tertiary care physical medicine and rehabilitation facility in France were consecutively screened. A total of 185 hospitalized for non-specific cLBP were prospectively assessed. Forty patients fulfilling inclusion criteria were consecutively enrolled and included in 2 groups according to MRI findings: Modic I (n = 15) and non-Modic I (n = 25). MRI findings were assessed independently by 2 spine specialists and a radiologist. HLA-B27 status was determined. Data were collected on clinical measurements and fulfillment of Amor criteria (AC) and modified New York criteria (mNYC). All assessors were blinded to HLA-B27 status.Results.Whatever the Modic group, no patient fulfilled AC or mNYC, and mean total scores were comparable [3 ± 2 (range 0–22; p = 0.977), 1 ± 1 (range 0–3; p = 1.000), and 0 ± 0 (range 0–1; p = 1.000) for AC and clinical and radiological mNYC, respectively]. HLA-B27 status was similar in both groups [n = 2 (13%) vs n = 0 (0%); p = 0.135].Conclusion.Patients with cLBP and Modic I vertebral endplate signal changes on lumbar MRI do not fulfill widely used and validated criteria for SpA and/or AS. Such cases are clinically distinct from SpA and AS.

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