Identification of an excitatory amino acid-mediated component of the ventral tegmental area local field potential response to medial prefrontal cortex stimulation: effect of acute d-amphetamine

2006 ◽  
Vol 114 (2) ◽  
pp. 161-172 ◽  
Author(s):  
E. J. Dommett ◽  
J. Simpson ◽  
D. Clark ◽  
P. G. Overton
Keyword(s):  
Prefrontal Cortex ◽  
Amino Acid ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Local Field ◽  
Local Field Potential ◽  
Excitatory Amino Acid ◽  
Field Potential ◽  
Potential Response ◽  
Ventral Tegmental

Theta activity in local field potential of the ventral tegmental area in sleeping and waking rats

2014 ◽  
Vol 265 ◽  
pp. 84-92 ◽  
Author(s):  
Jolanta Orzeł-Gryglewska ◽  
Paweł Matulewicz ◽  
Edyta Jurkowlaniec
Keyword(s):  
Ventral Tegmental Area ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Theta Activity ◽  
Ventral Tegmental

scholarly journals Acute and chronic pain affects local field potential of the medial prefrontal cortex in different band neural oscillations

2018 ◽  
Vol 14 ◽  
pp. 174480691878568 ◽  
Author(s):  
Bo Fu ◽  
Shao-nan Wen ◽  
Bin Wang ◽  
Kun Wang ◽  
Ji-yan Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Neural Oscillations

Reduced local field potential power in the medial prefrontal cortex by noxious stimuli

2016 ◽  
Vol 127 ◽  
pp. 92-99 ◽  
Author(s):  
Ai-Ling Li ◽  
Xiaofei Yang ◽  
Jung-Chih Chiao ◽  
Yuan Bo Peng
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Noxious Stimuli

scholarly journals Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens

2022 ◽  
Author(s):  
Imre Kalló ◽  
Azar Omrani ◽  
Frank J. Meye ◽  
Han de Jong ◽  
Zsolt Liposits ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Dopamine Neurons ◽  
Regulatory Processes ◽  
Ventral Tegmental ◽  
Shell Part

AbstractOrexin neurons are involved in homeostatic regulatory processes, including arousal and feeding, and provide a major input from the hypothalamus to the ventral tegmental area (VTA) of the midbrain. VTA neurons are a central hub processing reward and motivation and target the medial prefrontal cortex (mPFC) and the shell part of nucleus accumbens (NAcs). We investigated whether subpopulations of dopamine (DA) neurons in the VTA projecting either to the mPFC or the medial division of shell part of nucleus accumbens (mNAcs) receive differential input from orexin neurons and whether orexin exerts differential electrophysiological effects upon these cells. VTA neurons projecting to the mPFC or the mNAcs were traced retrogradely by Cav2-Cre virus and identified by expression of yellow fluorescent protein (YFP). Immunocytochemical analysis showed that a higher proportion of all orexin-innervated DA neurons projected to the mNAcs (34.5%) than to the mPFC (5.2%). Of all sampled VTA neurons projecting either to the mPFC or mNAcs, the dopaminergic (68.3 vs. 79.6%) and orexin-innervated DA neurons (68.9 vs. 64.4%) represented the major phenotype. Whole-cell current clamp recordings were obtained from fluorescently labeled neurons in slices during baseline periods and bath application of orexin A. Orexin similarly increased the firing rate of VTA dopamine neurons projecting to mNAcs (1.99 ± 0.61 Hz to 2.53 ± 0.72 Hz) and mPFC (0.40 ± 0.22 Hz to 1.45 ± 0.56 Hz). Thus, the hypothalamic orexin system targets mNAcs and to a lesser extent mPFC-projecting dopaminergic neurons of the VTA and exerts facilitatory effects on both clusters of dopamine neurons.

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