A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C

2014 ◽  
Vol 159 (11) ◽  
pp. 2925-2935 ◽  
Author(s):  
Wei Zheng ◽  
Xiaying Li ◽  
Jianchang Wang ◽  
Xiaoqi Li ◽  
Hong Cao ◽  
...  
Keyword(s):  
Disease Virus ◽  
Type I Interferon ◽  
Critical Role ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Interferon Response ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Porcine Type I Interferon Rapidly Protects Swine Against Challenge with Multiple Serotypes of Foot-and-Mouth Disease Virus

2011 ◽  
Vol 31 (2) ◽  
pp. 227-236 ◽  
Author(s):  
Camila C.A. Dias ◽  
Mauro P. Moraes ◽  
Fayna Diaz-San Segundo ◽  
Teresa de los Santos ◽  
Marvin J. Grubman
Keyword(s):  
Disease Virus ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication

2016 ◽  
Vol 75 ◽  
pp. 112-121 ◽  
Author(s):  
Weiwei Li ◽  
Zixiang Zhu ◽  
Weijun Cao ◽  
Fan Yang ◽  
Xiangle Zhang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Disease Virus ◽  
Virus Replication ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Type I Interferon Induced and Antagonized by Foot-and-Mouth Disease Virus

2018 ◽  
Vol 9 ◽  
Author(s):  
Xiao-xia Ma ◽  
Li-na Ma ◽  
Qiu-yan Chang ◽  
Peng Ma ◽  
Lin-Jie Li ◽  
...  
Keyword(s):  
Disease Virus ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Adenovirus-Mediated Type I Interferon Expression Delays and Reduces Disease Signs in Cattle Challenged with Foot-and-Mouth Disease Virus

2003 ◽  
Vol 23 (7) ◽  
pp. 359-368 ◽  
Author(s):  
Qiaohua Wu ◽  
Mario C.S. Brum ◽  
Luizinho Caron ◽  
Marla Koster ◽  
Marvin J. Grubman
Keyword(s):  
Disease Virus ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth

A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis

2012 ◽  
Vol 170 (1-2) ◽  
pp. 59-65 ◽  
Author(s):  
Jianchang Wang ◽  
Yongqiang Wang ◽  
Jue Liu ◽  
Lin Ding ◽  
Quanhong Zhang ◽  
...  
Keyword(s):  
Disease Virus ◽  
Critical Role ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Induced Apoptosis

scholarly journals Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation

2020 ◽  
Vol 16 (11) ◽  
pp. e1009057
Author(s):  
Pathum Ekanayaka ◽  
Seo-Yong Lee ◽  
Thilina U. B. Herath ◽  
Jae-Hoon Kim ◽  
Tae-Hwan Kim ◽  
...  
Keyword(s):  
Cell Culture ◽  
Disease Virus ◽  
Critical Role ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Wild Type ◽  
Humoral Immune ◽  
Mouth Disease Virus ◽  
Foot And Mouth

VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the virus. In addition, FMDV VP1 modulates host IFN signal transduction. Here, we examined the ability of cell culture-adapted FMDV VP1(83K) and wild-type FMDV VP1(83E) to evade host immunity by blocking mitochondrial antiviral signaling protein (MAVS)/TNF Receptor Associated Factor 3 (TRAF3) mediated cellular innate responses. Wild-type FMDV VP1(83E) interacted specifically with C-terminal TRAF3-binding site within MAVS and this interaction inhibited binding of TRAF3 to MAVS, thereby suppressing interferon-mediated responses. This was not observed for cell culture-adapted FMDV VP1(83K). Finally, chimeric FMDV harboring VP1(83K) showed very low pathogenicity in pigs. Collectively, these data highlight a critical role of VP1 with respect to suppression of type-I IFN pathway and attenuation of FMDV by the E83K mutation in VP1.

scholarly journals A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro

2019 ◽  
Vol 127 ◽  
pp. 79-84 ◽  
Author(s):  
Shi-fang Li ◽  
Mei-jiao Gong ◽  
Yin-li Xie ◽  
Jun–jun Shao ◽  
Fu-rong Zhao ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Disease Virus ◽  
Type I Interferon ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Type I ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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