Natural infection of captive cynomolgus monkeys (Macaca fascicularis) with hepatitis E virus genotype 4

2019 ◽  
Vol 164 (10) ◽  
pp. 2515-2518 ◽  
Author(s):  
Dmitriy I. Dogadov ◽  
L. I. Korzaya ◽  
K. K. Kyuregyan ◽  
A. A. Karlsen ◽  
V. S. Kichatova ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Macaca Fascicularis ◽  
Natural Infection ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4 ◽  
Cynomolgus Monkeys

Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4

2019 ◽  
Vol 229 ◽  
pp. 168-175 ◽  
Author(s):  
Baoyuan Liu ◽  
Yiyang Chen ◽  
Yani Sun ◽  
Yuchen Nan ◽  
Huixia Li ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4

scholarly journals The Leu477 and Leu613 of ORF2-Encoded Protein Are Critical in Forming Neutralization Antigenic Epitope of Hepatitis E Virus Genotype 4

2008 ◽  
Vol 5 (6) ◽  
pp. 447-456 ◽  
Author(s):  
Hongmei Zhang ◽  
Xing Dai ◽  
Xiangnian Shan ◽  
Jihong Meng
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Antigenic Epitope ◽  
Virus Genotype ◽  
Genotype 4

Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis

2012 ◽  
Vol 158 (1) ◽  
pp. 165-172 ◽  
Author(s):  
Qiuning Bu ◽  
Xiaojuan Wang ◽  
Ling Wang ◽  
Peng Liu ◽  
Jiabao Geng ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Full Length ◽  
Virus Genotype ◽  
Genotype 4 ◽  
Full Length Sequence

The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3

Microbiology ◽  
2000 ◽  
Vol 81 (7) ◽  
pp. 1675-1686 ◽  
Author(s):  
Youchun Wang ◽  
Huayuan Zhang ◽  
Roger Ling ◽  
Hemin Li ◽  
Tim J. Harrison
Keyword(s):  
Hepatitis E Virus ◽  
Genomic Sequence ◽  
Sequence Data ◽  
Hepatitis E ◽  
Complete Sequence ◽  
Open Reading Frames ◽  
Virus Genotype ◽  
Nucleotide Substitutions ◽  
Genotype 4 ◽  
Novel Genotype

Isolates of hepatitis E virus (HEV) have recently been described from China that are distinct from Burmese, Mexican and US viruses and constitute a novel genotype (genotype 4). Here, the complete genomic sequence of a representative isolate of genotype 4 HEV, amplified directly from the stool of an acutely infected patient, is presented. Analysis of the entire sequence confirms our previous conclusion, based upon partial sequence data, that these Chinese isolates belong to a novel genotype. Typical of genetic variation in HEV, most nucleotide substitutions occur in the third base of the codon and do not affect the amino acid sequence. The genotype 4 virus is unusual in that a single nucleotide insertion in the ORF 3 region changes the initiation of ORF 3, and perhaps also ORF 2. The consequences of these changes are discussed.

scholarly journals First Isolation of Hepatitis E Virus Genotype 4 in Europe through Swine Surveillance in the Netherlands and Belgium

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e22673 ◽  
Author(s):  
Renate W. Hakze-van der Honing ◽  
Els van Coillie ◽  
Adriaan F. G. Antonis ◽  
Wim H. M. van der Poel
Keyword(s):  
The Netherlands ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4

Isolation of hepatitis E virus genotype 4 from patients with acute cryptogenic hepatitis in Korea

2017 ◽  
Vol 89 ◽  
pp. 10-13 ◽  
Author(s):  
Sook-Hyang Jeong ◽  
Byung-Joo Park ◽  
Yong-Hyun Kim ◽  
Yun Suk Choi ◽  
Hee-Seop Ahn ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4 ◽  
Cryptogenic Hepatitis

scholarly journals Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174070 ◽  
Author(s):  
Noemi Rovaris Gardinali ◽  
Juliana Rodrigues Guimarães ◽  
Juliana Gil Melgaço ◽  
Yohan Britto Kevorkian ◽  
Fernanda de Oliveira Bottino ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Cynomolgus Monkeys ◽  
Persistently Infected

Hepatitis E virus genotype 4 in a pig farm, Italy, 2013

2014 ◽  
Vol 143 (3) ◽  
pp. 529-533 ◽  
Author(s):  
I. MONNE ◽  
L. CEGLIE ◽  
G. DI MARTINO ◽  
A. NATALE ◽  
S. ZAMPROGNA ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Genotype 4 ◽  
North East ◽  
The North ◽  
Pig Farm ◽  
Swine Population ◽  
First Time

SUMMARYZoonotic strains of hepatitis E virus (HEV) in Europe have been reported to belong to genotypes 3 and 4. In 2012 and 2013, 57 pig farms in Northern Italy that had previously resulted seropositive for HEV were surveyed for the presence of the virus, with positive samples subsequently genotyped. Hepatitis E RNA was identified in 17/57 (29·8%) seropositive farms. Phylogenetic analysis demonstrated that distinct subtypes of genotype 3 were circulating in the north-east of Italy; as well, for the first time in the Italian swine population, genotype 4 was identified and attributed to subtype d.

scholarly journals Hepatitis E Virus Genotype 4, Nanjing, China, 2001–2011

2013 ◽  
Vol 19 (9) ◽  
pp. 1528-1530 ◽  
Author(s):  
Xing Dai ◽  
Chen Dong ◽  
Zhenxian Zhou ◽  
Jiuhong Liang ◽  
Min Dong ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4
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