Does family history of depression predict major depression in midlife women? Study of Women’s Health Across the Nation Mental Health Study (SWAN MHS)

BackgroundIn women, anxiety symptoms are common and increase during midlife, but little is known about whether these symptoms predict onsets of major depressive disorder (MDD) episodes. We examined whether anxiety symptoms are associated with subsequent episodes of MDD in midlife African-American and Caucasian women, and whether they confer a different risk for first versus recurrent MDD episodes.MethodA longitudinal analysis was conducted using 12 years of data from the Study of Women's Health Across the Nation (SWAN) Mental Health Study (MHS). The baseline sample comprised 425 Caucasian (n = 278) and African American (n = 147) community-dwelling women, aged 46.1 ± 2.5 years. Anxiety symptoms measured annually using a self-report questionnaire were examined in relation to MDD episodes in the subsequent year, assessed with the SCID. Multivariable models were estimated with random effects logistic regression.ResultsHigher anxiety symptoms scores were associated with a significantly higher adjusted odds of developing an episode of MDD at the subsequent annual visit [odds ratio (OR) 1.47, p = 0.01], specifically for a recurrent episode (OR 1.49, p = 0.03) but non-significant for a first episode (OR 1.32, p = 0.27). There were no significant racial effects in the association between anxiety symptoms and subsequent MDD episodes.ConclusionsAnxiety symptoms often precede MDD and may increase the vulnerability of midlife women to depressive episodes, particularly recurrences. Women with anxiety symptoms should be monitored clinically during the ensuing year for the development of an MDD episode.

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Family history of depression is associated with alterations in task‐dependent connectivity between the cerebellum and ventromedial prefrontal cortex

Depression and Anxiety ◽

10.1002/da.23143 ◽

2021 ◽

Author(s):

Lindsey J. Tepfer ◽

Lauren B. Alloy ◽

David V. Smith

Keyword(s):

Prefrontal Cortex ◽

Family History ◽

Ventromedial Prefrontal Cortex ◽

History Of ◽

Family History Of Depression ◽

History Of Depression

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Understanding the interplay of individual and social–developmental factors in the progression of substance use and mental health from childhood to adulthood

Development and Psychopathology ◽

10.1017/s0954579416000274 ◽

2016 ◽

Vol 28 (3) ◽

pp. 721-741 ◽

Cited By ~ 7

Author(s):

Tiffany M. Jones ◽

Karl G. Hill ◽

Marina Epstein ◽

Jungeun Olivia Lee ◽

J. David Hawkins ◽

...

Keyword(s):

Mental Health ◽

Substance Use ◽

Social Environments ◽

Developmental Factors ◽

Substance Use Problems ◽

History Of ◽

Individual Functioning ◽

Family History Of Depression ◽

History Of Depression

AbstractThis study examines the interplay between individual and social–developmental factors in the development of positive functioning, substance use problems, and mental health problems. This interplay is nested within positive and negative developmental cascades that span childhood, adolescence, the transition to adulthood, and adulthood. Data are drawn from the Seattle Social Development Project, a gender-balanced, ethnically diverse community sample of 808 participants interviewed 12 times from ages 10 to 33. Path modeling showed short- and long-term cascading effects of positive social environments, family history of depression, and substance-using social environments throughout development. Positive family social environments set a template for future partner social environment interaction and had positive influences on proximal individual functioning, both in the next developmental period and long term. Family history of depression adversely affected mental health functioning throughout adulthood. Family substance use began a cascade of substance-specific social environments across development, which was the pathway through which increasing severity of substance use problems flowed. The model also indicated that adolescent, but not adult, individual functioning influenced selection into positive social environments, and significant cross-domain effects were found in which substance-using social environments affected subsequent mental health.

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Effect on Neuropsychiatric Disorders of Organophosphate Pesticides Exposure among Rice Farmers in Sukoharjo, Central Java

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions ◽

10.26911/the7thicph.01.48 ◽

2020 ◽

Author(s):

Ayu Laela Fitriyani ◽

◽

Setyo Sri Rahardjo ◽

Bhisma Murti ◽

◽

...

Keyword(s):

Family History ◽

Work Stress ◽

Depression And Anxiety ◽

High Exposure ◽

Rice Farmers ◽

Central Java ◽

Loss And Grief ◽

History Of ◽

Family History Of Depression ◽

History Of Depression

ABSTRACT Background: Chronic exposure to organophosphate pesticides can increase the risk of neuropsychiatric disorders, including depression and anxiety. Unsafe behavior from farmers will endanger the health of farmers, especially in the form of neuropsychiatric disorders (depression and anxiety). This study aimed to analyze the effects of pesticide exposure and psychosocial determinants on depression and anxiety. Subjects and Method: A retrospective cohort study was conducted in Sukoharjo, Central Java. The study population was rice farmers. A sample of 200 rice farmers who use organophospate pesticide was selected by fixed exposure sampling. The dependent variable was neuropsychiatry (anxiety and depression). The independent variables were exposure to organophospate pesticide, had family history of depression, loss and grief, post trauma, work stress, and the use of personal protective equipment (PPE). The data were collected by questionnaire and analyzed by a multiple linear regression. Results: The risk of depression increased with high exposure to organophospate pesticide (b= 0.15; 95% CI= 0.05 to 0.26; p= 0.005), had family history of depression (b= 5.10; 95% CI= 2.60 to 7.60; p<0.001), loss and grief (b= 2.94; 95% CI= 0.76 to 5.11; p= 0.008), post trauma (b= 2.57; 95% CI= 0.24 to 4.89; p= 0.031), and work stress (b= 0.16; 95% CI= 0.05 to 0.27; p= 0.005). The risk of depression decreased with the use of PPE (b= -0.69; 95% CI= -1.32 to -0.076; p= 0.028). The risk of anxiety increased with high exposure to organophospate pesticide (b= 0.13; 95% CI= 0.02 to 0.24; p= 0.025), post trauma (b= 5.96; 95% CI= 3.48 to 8.44; p<0.001), loss and grief (b= 3.39; 95% CI= 1.07 to 5.71; p<0.001), had family history of depression (b= 2.95; 95% CI= 0.29 to 5.62; p= 0.004), and work stress (b= 0.19; 95% CI= 0.07 to 0.30; p=0.002). The risk of anxiety decreased with the use of PPE (b= -0.09; 95% CI= -1.57 to -0.024; p=0.008). Conclusion: The risk of depression increases with high exposure to organophospate pesticide, family history of depression, loss and grief, post trauma, and work stress. The risk of depression decreases with the use of PPE. The risk of anxiety increases with high exposure to organophospate pesticide, post trauma, loss and grief, had family history of depression, and work stress. The risk of anxiety decreases with the use of PPE. Keywords: Neuropsychiatry disorder, depression, anxiety Correspondence: Ayu Laela Fitriyani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +625796333986. DOI: https://doi.org/10.26911/the7thicph.01.48

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