Pharmacological and interventional pain therapy in patients with vascular diseases – an interdisciplinary concept of treatment

1999 ◽  
Vol 4 (2) ◽  
pp. 70
Author(s):  
K. Maier ◽  
K. Merzoug
Keyword(s):  
Pain Therapy ◽  
Vascular Diseases ◽  
Interventional Pain Therapy ◽  
Interdisciplinary Concept

scholarly journals Interventional pain therapy in cervical post-surgery syndrome

2016 ◽  
Vol 5 (2) ◽  
pp. 38
Author(s):  
Stephan Klessinger
Keyword(s):  
Pain Therapy ◽  
Post Surgery ◽  
Interventional Pain Therapy

Interventional Pain Therapy for Intractable Abdominal Cancer Pain

2000 ◽  
Vol 18 (7) ◽  
pp. 1598-1600 ◽  
Author(s):  
David P. Seamans ◽  
Gilbert Y. Wong ◽  
Jack L. Wilson
Keyword(s):  
Cancer Pain ◽  
Pain Therapy ◽  
Interventional Pain Therapy

Interventional Pain Therapy for Intractable Abdominal Cancer Pain

2003 ◽  
Vol 21 (90090) ◽  
pp. 92s-94 ◽  
Author(s):  
D. P. Seamans
Keyword(s):  
Cancer Pain ◽  
Pain Therapy ◽  
Interventional Pain Therapy

553 INTERVENTIONAL PAIN THERAPY IN PALLIATIVE CARE: A CASE SERIES

2006 ◽  
Vol 10 (S1) ◽  
pp. S146-S146
Author(s):  
M. Escher ◽  
A. Cahana ◽  
L. Robert ◽  
S. Pautex
Keyword(s):  
Palliative Care ◽  
Pain Therapy ◽  
Case Series ◽  
Interventional Pain Therapy

scholarly journals The Gel Box – a Testing Device for the Characterization of Cryo- and Radiofrequency Lesions Employed in Interventional Pain Therapy

2010 ◽  
Vol 3;13 (3;5) ◽  
pp. 263-271
Author(s):  
Christof Birkenmaier
Keyword(s):  
Pain Therapy ◽  
Clinical Success ◽  
Sensory Nerve ◽  
Gel Point ◽  
Success Rates ◽  
Capillary Perfusion ◽  
Agar Gel ◽  
Wide Range ◽  
Technical Specifications ◽  
Interventional Pain Therapy

Background: Radiofrequency (RF) and cryolesioning are established methods for the therapeutic interruption of sensory nerve supply to facet joints and other painful musculoskeletal structures. The varying clinical success rates of these treatments have – among other technical issues – been attributed to the small size of these lesions combined with the limited precision in placing them. Since there are 2 different physical methods for lesioning and a wide range of probes and lesion generators available, it is likely that the lesions generated by them may be of different size. Objectives: We sought to devise an experimental setup that would allow for the reproducible and comparable evaluation of the size of cryo and RF lesions as they are being used in interventional pain therapy. Methods: A wide range of potential media was evaluated for this purpose. Based on technical specifications, as well as on preliminary testing, a specific agar agar gel with a gel point of between 32o C and 35o C and a melting point of between 80o C and 85o C was selected for these experiments. Two different testing containers were constructed from transparent acrylic: one with a volume of 1,500 mL and the other with a volume of 12 mL. Each of them allows for the introduction of a cryo or a RF probe and 2 bundles of thermoelements into the gel volume. A water bath was used to maintain the gels at 37o C and bundled, ultrafine NiCr-Ni thermoelements type K were used for measuring the isotherms. A series of RF and cryolesions were performed within these experimental setups to evaluate their suitability for the comparative testing of cryo and RF probes and generators. Results: Both testing setups generated reproducible results and proved to be suitable for measuring RF as well as cryolesions. Visual observation of the lesions was better with the small testing container and rewarming / recooling after performing a cryo / RF lesion was more rapid with the smaller gel volume. Limitations: Our setup allows for the comparative measurement of RF and cryolesions, but it cannot simulate the realities within living tissue. While convection as a confounding factor was excluded by use of a gel, capillary perfusion and the specific characteristics of different tissues cannot be simulated. Conclusions: The testing setup described in this manuscript can serve for the comparative and reproducible study of RF and cryolesions that are commonly used in interventional pain therapy. Key words: Radiofrequency lesioning, cryolesioning, interventional pain therapy, experimental study, agar agar gel, thermoelement.

Unilateral Diagnostic Infiltration of Lumbar L3 Nerve Root Resulting in an Inadvertent Discogram: The Importance of Fluoroscopic Guidance in Interventional Pain Therapy

2004 ◽  
Vol 100 (4) ◽  
pp. 1019-1021 ◽  
Author(s):  
Sara Haspeslagh ◽  
Jan Van Zundert ◽  
Martine Puylaert ◽  
Rene Heylen ◽  
Maarten van Kleef ◽  
...  
Keyword(s):  
Nerve Root ◽  
Pain Therapy ◽  
Fluoroscopic Guidance ◽  
Interventional Pain Therapy

The molecular mechanism of mechanotransduction in vascular homeostasis and disease

2020 ◽  
Vol 134 (17) ◽  
pp. 2399-2418
Author(s):  
Yoshito Yamashiro ◽  
Hiromi Yanagisawa
Keyword(s):  
Shear Stress ◽  
Blood Vessels ◽  
Vessel Wall ◽  
Vascular Diseases ◽  
Cell Interactions ◽  
Aortic Aneurysms ◽  
Cyclic Stretch ◽  
Mechanical Stimuli ◽  
Vascular Homeostasis ◽  
Matrix Cell

Abstract Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel wall and coordinates with a dynamic mechanical environment to provide cues to initiate intracellular signaling pathway(s), thereby changing cellular behaviors and functions. However, the precise role of matrix–cell interactions involved in mechanotransduction during vascular homeostasis and disease development remains to be fully determined. In this review, we introduce hemodynamics forces in blood vessels and the initial sensors of mechanical stimuli, including cell–cell junctional molecules, G-protein-coupled receptors (GPCRs), multiple ion channels, and a variety of small GTPases. We then highlight the molecular mechanotransduction events in the vessel wall triggered by laminar shear stress (LSS) and disturbed shear stress (DSS) on vascular endothelial cells (ECs), and cyclic stretch in ECs and vascular smooth muscle cells (SMCs)—both of which activate several key transcription factors. Finally, we provide a recent overview of matrix–cell interactions and mechanotransduction centered on fibronectin in ECs and thrombospondin-1 in SMCs. The results of this review suggest that abnormal mechanical cues or altered responses to mechanical stimuli in EC and SMCs serve as the molecular basis of vascular diseases such as atherosclerosis, hypertension and aortic aneurysms. Collecting evidence and advancing knowledge on the mechanotransduction in the vessel wall can lead to a new direction of therapeutic interventions for vascular diseases.

Don't Withhold Opioid Pain Therapy From Recovering Addicts

2006 ◽  
Vol 39 (11) ◽  
pp. 47
Author(s):  
BRUCE K. DIXON
Keyword(s):  
Pain Therapy ◽  
Recovering Addicts
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