Birth weight is an independent determinant of whole body bone mineral content and bone mineral density in a group of Lebanese adolescent girls

A previous study using single photon absorptiometry has reported low bone mineral density of the radius in infants of diabetic mothers. The aim of this study was to assess by dual x-ray absorptiometry the whole body bone mineral content (WbBMC) and the body composition of 40 infants of diabetic mothers at birth (mean gestational age ± sd, 37.5 ± 1.3 weeks; mean birth weight ± sd, 3815 ± 641 g). WbBMC was not correlated with gestational age, but was well correlated with birth weight (r = 0.73; P = 0.0001) and also with fat mass (r = 0.87; P = 0.0001) and lean mass (r = 0.42; P = 0.008). The z-scores ± sd adjusted for weight for WbBMC and fat mass were significantly increased (1.3 ± 0.9 and 2.6 ± 1.3, respectively (P < 0.0001), but were not significantly influenced either by in utero growth or by the type of the diabetes mellitus of the mother. Bone mineralization and fat mass studied by whole body dual x-ray absorptiometry are increased at birth in these infants compared with reference curves.

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Daily Treatment with Human Recombinant Parathyroid Hormone-(1–34), LY333334, for 1 Year Increases Bone Mass in Ovariectomized Monkeys*

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.84.10.6039 ◽

1999 ◽

Vol 84 (10) ◽

pp. 3757-3763 ◽

Cited By ~ 1

Author(s):

Robert Brommage ◽

Charlotte E. Hotchkiss ◽

Cynthia J. Lees ◽

Melanie W. Stancill ◽

Janet M. Hock ◽

...

Keyword(s):

Bone Mass ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Proximal Tibia ◽

Whole Body ◽

Mineral Density ◽

Increase Bone Mass ◽

Skeletal Effects ◽

Body Bone

AbstractPTH stimulates bone formation to increase bone mass and strength in rats and humans. The aim of this study was to determine the skeletal effects of recombinant human PTH-(1–34) [rhPTH-(1–34)] in monkeys, as monkey bone remodeling and structure are similar to those in human bone.Adult female cynomolgus monkeys were divided into sham-vehicle (n= 21), ovariectomized (OVX)-vehicle (n = 20), and OVX groups given daily sc injections of rhPTH-(1–34) at 1 (n = 39) or 5 (n = 41) μg/kg for 12 months. Whole body bone mineral content was measured, as was bone mineral density (BMD) in the spine, proximal tibia, midshaft radius, and distal radius. Serum and urine samples were also analyzed. rhPTH-(1–34) treatment did not influence serum ionized Ca levels or urinary Ca excretion, but depressed endogenous PTH while increasing serum calcitriol levels. Compared to that in the OVX group, the higher dose of rhPTH-(1–34) increased spine BMD by 14.3%, whole body bone mineral content by 8.6%, and proximal tibia BMD by 10.8%. Subregion analyses suggested that the anabolic effect of rhPTH-(1–34) on the proximal tibia was primarily in cancellous bone. Similar, but less dramatic, effects on BMD were observed with the lower dose of rhPTH-(1–34). Daily sc rhPTH-(1–34) treatment for 1 yr increases BMD in ovariectomized monkeys without inducing sustained hypercalcemia or hypercalciuria.

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Bone mineral density and total body bone mineral content in 18- to 22-year-old women

Bone ◽

10.1016/j.bone.2004.01.021 ◽

2004 ◽

Vol 34 (6) ◽

pp. 1037-1043 ◽

Cited By ~ 6

Author(s):

Almond J Drake ◽

David W Armstrong ◽

K.M.M Shakir

Keyword(s):

Bone Mineral Density ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Mineral Density ◽

Total Body ◽

Total Body Bone Mineral ◽

Body Bone

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Correlates and determinants of bone mineral content and density in healthy adolescent girls

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y93-140 ◽

1993 ◽

Vol 71 (12) ◽

pp. 923-930 ◽

Cited By ~ 16

Author(s):

S. Rice ◽

C. J. R. Blimkie ◽

C. E. Webber ◽

D. Levy ◽

J. Martin ◽

...

Keyword(s):

Growth Hormone ◽

Bone Mineral Content ◽

Body Mass ◽

Bone Mineral ◽

Adolescent Girls ◽

Mineral Content ◽

Significant Proportion ◽

Whole Body ◽

Explained Variance ◽

Body Bone

The relationships between whole-body and lumbar spine bone mineral content and density, and measures of chronologic age, body composition, physical activity, cardiorespiratory and strength fitness, gynecologic attributes, sexual maturity, and endocrine status were studied in 35 healthy menarcheal girls (14–18 years of age). Body mass (0.464 < r < 0.704), growth hormone (−0.34 < r < −0.42), and one-repetition maximum double-leg press strength (0.343 < r < 0.467) were significantly (p < 0.05) correlated with each of the five bone mineral measures. Multiple regression analysis indicated that body mass accounted for the largest significant proportion of the explained variance (30.2–68.2%) in each of the five bone mineral measures. Age at first menses accounted for a smaller but still significant proportion of the variance in whole-body bone mineral content (4.05%) and lumbar spine bone mineral content (8.06%). Growth hormone entered the regression model as an important predictor of whole-body bone mineral content, accounting for 3.51% of the explained variance in this variable. Age, cardiorespiratory fitness, level of habitual activity, and strength did not contribute significantly to the explained variance in any of the bone mineral measures. Body mass appears to be the single most important determinant of bone mineral among females during this developmental period.Key words: bone density, adolescent girls, body composition, physical fitness, gynecologic characteristics, endocrine factors.

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