Combination therapy with ONO-KK1-300-01, a cathepsin K inhibitor, and parathyroid hormone results in additive beneficial effect on bone mineral density in ovariectomized rats

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-014-0643-1 ◽

2015 ◽

Vol 34 (1) ◽

pp. 33-40 ◽

Author(s):

Yasuo Ochi ◽

Hiroyuki Yamada ◽

Hiroshi Mori ◽

Naoki Kawada ◽

Makoto Tanaka ◽

...

Keyword(s):

Bone Mineral Density ◽

Parathyroid Hormone ◽

Combination Therapy ◽

Beneficial Effect ◽

Bone Mineral ◽

Cathepsin K ◽

Ovariectomized Rats ◽

Mineral Density ◽

Cathepsin K Inhibitor

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Letter: The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2012.27.1.105 ◽

2012 ◽

Vol 27 (1) ◽

pp. 105

Author(s):

Sang Ah Lee

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2011.26.4.303 ◽

2011 ◽

Vol 26 (4) ◽

pp. 303 ◽

Author(s):

Seung Hun Lee ◽

Jung-Min Koh ◽

Young-Sun Lee ◽

Beom-Jun Kim ◽

Je-Yong Choi ◽

...

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change of Bone Mineral Density in Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2011.26.4.295 ◽

2011 ◽

Vol 26 (4) ◽

pp. 295 ◽

Author(s):

Yumie Rhee

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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Response: The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2012.27.1.107 ◽

2012 ◽

Vol 27 (1) ◽

pp. 107

Author(s):

Seung Hun Lee ◽

Jung-Min Koh ◽

Young-Sun Lee ◽

Beom-Jun Kim ◽

Je-Yong Choi ◽

...

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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Effect of a cathepsin K inhibitor on arthritis and bone mineral density in ovariectomized rats with collagen-induced arthritis

Bone Reports ◽

10.1016/j.bonr.2018.05.006 ◽

2018 ◽

Vol 9 ◽

pp. 1-10 ◽

Author(s):

Takahiro Yamashita ◽

Hiroshi Hagino ◽

Ikuta Hayashi ◽

Masako Hayashibara ◽

Atsushi Tanida ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Cathepsin K ◽

Ovariectomized Rats ◽

Mineral Density ◽

Collagen Induced Arthritis ◽

Cathepsin K Inhibitor

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Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.279 ◽

2014 ◽

Vol 54 (8) ◽

pp. 937-948 ◽

Author(s):

Chihiro Hasegawa ◽

Helen Kastrissios ◽

Jonathan Monteleone ◽

Tomoya Ohno ◽

Takeo Umemura ◽

...

Keyword(s):

Bone Mineral Density ◽

Modeling And Simulation ◽

Bone Mineral ◽

Cathepsin K ◽

Phase 2 ◽

Mineral Density ◽

Dose Selection ◽

Cathepsin K Inhibitor ◽

Phase 2 Study ◽

Density Response

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Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover markers and bone mineral density in ovariectomized cynomolgus monkeys

Bone ◽

10.1016/j.bone.2010.04.598 ◽

2010 ◽

Vol 47 ◽

pp. S70-S71 ◽

Author(s):

H. Yamada⁎ ◽

H. Mori ◽

A. Kunishige ◽

S. Nishikawa ◽

Y. Hashimoto ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Turnover ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Cathepsin K ◽

Mineral Density ◽

Cynomolgus Monkeys ◽

Cathepsin K Inhibitor ◽

Turnover Markers

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Four-year Results of a Phase 2 Study of the Cathepsin K Inhibitor Odanacatib in Postmenopausal Women with Low Bone Mineral Density: Effects on Bone Mineral Density and Bone Turnover Markers

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2011.02.042 ◽

2011 ◽

Vol 14 (2) ◽

pp. 165

Author(s):

Paul Miller ◽

Neil Binkley ◽

John Eisman ◽

Ian Reid ◽

Antonio Lombardi

Keyword(s):

Bone Mineral Density ◽

Bone Turnover ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Cathepsin K ◽

Phase 2 ◽

Mineral Density ◽

Cathepsin K Inhibitor ◽

Phase 2 Study ◽

Turnover Markers

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Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-018-0968-2 ◽

2018 ◽

Vol 37 (4) ◽

pp. 636-647 ◽

Author(s):

Hiroyuki Yamada ◽

Yasuo Ochi ◽

Hiroshi Mori ◽

Satoshi Nishikawa ◽

Yasuaki Hashimoto ◽

...

Keyword(s):

Bone Mineral Density ◽

Cortical Bone ◽

Bone Strength ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cynomolgus Monkeys ◽

Cathepsin K Inhibitor ◽

Cortical Bone Mineral Density

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Effect of the cathepsin K inhibitor odanacatib administered once weekly on bone mineral density in Japanese patients with osteoporosis—a double-blind, randomized, dose-finding study

Osteoporosis International ◽

10.1007/s00198-013-2398-2 ◽

2013 ◽

Vol 25 (1) ◽

pp. 367-376 ◽

Author(s):

T. Nakamura ◽

M. Shiraki ◽

M. Fukunaga ◽

T. Tomomitsu ◽

A. C. Santora ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Cathepsin K ◽

Japanese Patients ◽

Dose Finding ◽

Mineral Density ◽

Double Blind ◽

Cathepsin K Inhibitor ◽

Finding Study ◽

Dose Finding Study

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