Selenium-modified calcium phosphate cement can accelerate bone regeneration of osteoporotic bone defect

2021 ◽  
Author(s):  
Tian-Lin Li ◽  
Zhou-Shan Tao ◽  
Xing-jing Wu ◽  
Min Yang ◽  
Hong-Guang Xu
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Osteoporotic Bone

scholarly journals Treatment of bone defect with calcium phosphate cement subsequent to tumor curettage in pediatric patients

2015 ◽  
Vol 11 (1) ◽  
pp. 247-252 ◽  
Author(s):  
TOMOKI NAKAMURA ◽  
AKIHIKO MATSUMINE ◽  
KUNIHIRO ASANUMA ◽  
TAKAO MATSUBARA ◽  
AKIHIRO SUDO
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Pediatric Patients

Incorporation of biodegradable electrospun fibers into calcium phosphate cement for bone regeneration

2010 ◽  
Vol 6 (4) ◽  
pp. 1238-1247 ◽  
Author(s):  
Yi Zuo ◽  
Fang Yang ◽  
Joop G.C. Wolke ◽  
Yubao Li ◽  
John A. Jansen
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Electrospun Fibers

Substance P incorporation in calcium phosphate cement for dental alveolar bone defect restoration

2016 ◽  
Vol 69 ◽  
pp. 546-553 ◽  
Author(s):  
Tianjue Wang ◽  
Di Wu ◽  
Yuan Li ◽  
Wantao Li ◽  
Shuyin Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Substance P ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Alveolar Bone ◽  
Alveolar Bone Defect

Bone regeneration in critical-sized bone defect enhanced by introducing osteoinductivity to biphasic calcium phosphate granules

2016 ◽  
Vol 28 (3) ◽  
pp. 251-260 ◽  
Author(s):  
D. Wang ◽  
A. Tabassum ◽  
G. Wu ◽  
L. Deng ◽  
D. Wismeijer ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Biphasic Calcium Phosphate

Design and Fabrication of Complex Scaffolds for Bone Defect Healing: Combined 3D Plotting of a Calcium Phosphate Cement and a Growth Factor-Loaded Hydrogel

2016 ◽  
Vol 45 (1) ◽  
pp. 224-236 ◽  
Author(s):  
Tilman Ahlfeld ◽  
Ashwini Rahul Akkineni ◽  
Yvonne Förster ◽  
Tino Köhler ◽  
Sven Knaack ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Defect Healing ◽  
Bone Defect Healing

scholarly journals Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

2021 ◽  
Vol 2 ◽  
Author(s):  
Rashed A. Alsahafi ◽  
Heba Ahmed Mitwalli ◽  
Abdulrahman A. Balhaddad ◽  
Michael D. Weir ◽  
Hockin H. K. Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Current Status ◽  
Craniofacial Bone ◽  
Calcium Phosphate Cements ◽  
And Performance

The management and treatment of dental and craniofacial injuries have continued to evolve throughout the last several decades. Limitations with autograft, allograft, and synthetics created the need for more advanced approaches in tissue engineering. Calcium phosphate cements (CPC) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. This review focuses on the up-to-date performance of calcium phosphate cement (CPC) scaffolds and upcoming promising dental and craniofacial bone regeneration strategies. First, we summarized the barriers encountered in CPC scaffold development. Second, we compiled the most up to date in vitro and in vivo literature. Then, we conducted a systematic search of scientific articles in MEDLINE and EMBASE to screen the related studies. Lastly, we revealed the current developments to effectively design CPC scaffolds and track the enhanced viability and therapeutic efficacy to overcome the current limitations and upcoming perspectives. Finally, we presented a timely and opportune review article focusing on the significant potential of CPC scaffolds for dental and craniofacial bone regeneration, which will be discussed thoroughly. CPC offers multiple capabilities that may be considered toward the oral defects, expecting a future outlook in nanotechnology design and performance.

scholarly journals Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1392
Author(s):  
Harald Krenzlin ◽  
Andrea Foelger ◽  
Volker Mailänder ◽  
Christopher Blase ◽  
Marc Brockmann ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Pedicle Screw ◽  
Calcium Phosphate Cement ◽  
Pedicle Screws ◽  
Osteoblastic Differentiation ◽  
Collagen I ◽  
Osteoporotic Bone ◽  
Mineral Density ◽  
Screw Augmentation ◽  
Pullout Loads

Osteoporotic vertebral fractures often necessitate fusion surgery, with high rates of implant failure. We present a novel bioactive composite of calcium phosphate cement (CPC) and the collagen I mimetic P-15 for pedicle screw augmentation in osteoporotic bone. Methods involved expression analysis of osteogenesis-related genes during osteoblastic differentiation by RT-PCR and immunostaining of osteopontin and Ca2+ deposits. Untreated and decalcified sheep vertebrae were utilized for linear pullout testing of pedicle screws. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA). Expression of ALPI II (p < 0.0001), osteopontin (p < 0.0001), RUNX2 (p < 0.0001), and osteocalcin (p < 0.0001) was upregulated after co-culture of MSC with CPC-P-15. BMD was decreased by 28.75% ± 2.6%. Pullout loads in untreated vertebrae were 1405 ± 6 N (p < 0.001) without augmentation, 2010 ± 168 N (p < 0.0001) after augmentation with CPC-P-15, and 2112 ± 98 N (p < 0.0001) with PMMA. In decalcified vertebrae, pullout loads were 828 ± 66 N (p < 0.0001) without augmentation, 1324 ± 712 N (p = 0.04) with PMMA, and 1252 ± 131 N (p < 0.0078) with CPC-P-15. CPC-P-15 induces osteoblastic differentiation of human MES and improves pullout resistance of pedicle screws in osteoporotic and non-osteoporotic bone.

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