Hydrogen peroxide release kinetics into saliva from different whitening products: a double-blind, randomized clinical trial

2011 ◽  
Vol 16 (1) ◽  
pp. 155-163 ◽  
Author(s):  
Duarte Nuno da Silva Marques ◽  
António Duarte Sola Pereira da Mata ◽  
João Miguel Lourenço Silveira ◽  
Joana Rita Oliveira Faria Marques ◽  
João Pedro de Almeida Rato Amaral ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Release Kinetics ◽  
Double Blind ◽  
Hydrogen Peroxide Release

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p<0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p<0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (>0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

Effectiveness of 6% hydrogen peroxide concentration for tooth bleaching—A double-blind, randomized clinical trial

2015 ◽  
Vol 43 (8) ◽  
pp. 965-972 ◽  
Author(s):  
J. Martín ◽  
P. Vildósola ◽  
C. Bersezio ◽  
A. Herrera ◽  
J. Bortolatto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Tooth Bleaching ◽  
Double Blind

scholarly journals Effectiveness and safety of 3.0% hydrogen peroxide patch in a double-blind randomized clinical trial

2021 ◽  
Vol 17 (3) ◽  
pp. 163-163
Author(s):  
Jin-Kyoung Kim ◽  
Hyeonjeong Go ◽  
Jae-Hyun Ahn ◽  
Young-Eun Lee
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Double Blind
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