Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

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A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1184 ◽

2012 ◽

Vol 3 (4) ◽

pp. 330-334 ◽

Cited By ~ 2

Author(s):

Rubina Anjum ◽

Jasmin Singh ◽

Shailesh Kudva

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Periodic Acid ◽

Inflammatory Cells ◽

Probable Mechanism ◽

Stool Examination ◽

Gamma Aminobutyric Acid ◽

Predisposing Factor ◽

Cross Sectional ◽

Oral Lichen

ABSTRACT Aim Probable mechanism of pigmentation in oral lichen planus which is associated with anxiety disorder and its relation to gamma aminobutyric acid whose imbalance in brain occurs during stress and strain. Materials and methods A cross-sectional study comprising of 33 cases of clinically diagnosed oral lichen planus was conducted. Ethical clearance and informed consent was obtained. Detailed history was recorded and clinical examination was conducted. All patients were subjected to thorough routine blood, urine and stool examination for any systemic conditions. Clinical photographs and biopsies were obtained. The biopsy specimens were subjected to hematoxylin and eosin and periodic acid Schiff's reagent staining. Results Histopathological features of lichen planus include hyperkeratosis, liquefaction degeneration of stratum basale and subepithelial band of chronic inflammatory cells. Lichen planus is related to anxiety as predisposing factor. Conclusion Due to excitation of melanocytes lichen planus are seen with pigmentation. How to cite this article Anjum R, Singh J, Kudva S. A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus. World J Dent 2012;3(4):330-334.

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